第四届中美纳米医学与纳米生物技术年会 The 4th Annual Meeting of Chinese American Society of Nanomedicine and Nanobiotechnology 会议手册 Conference Handbook 19th - 22nd August 2019 | Hangzhou, China Welcome Message Dear Friends and Colleagues, On behalf of the organizing committee and Zhejiang University, the hosting institution, we welcome you to Hangzhou for the 4th International Symposium for Chinese American Society of Nanomedicine and Nanobiotechnology (CASNN) during August 20-22, 2019. CASNN was initially proposed by a group of active Chinese scholars in USA and China as an informal WeChat group and formally established in 2016. Its primary objective is to promote international communication, primarily between USA and China, for the advancement of nanomedicine and nanobiotechnology and to foster inclusive and collaborative interactions among researchers and institutions working in those areas. This annual symposium series has been successfully held in Nanjing (2018), Suzhou (2017) and Beijing (2016). The 4th CASNN meeting committee has invited and assembled a strong list of international speakers from academia, industry, and government agencies. This list includes 130 prominent scientists and leading experts with diverse backgrounds in Engineering, Chemistry, Medicine, and Pharmacy. In addition, there are more than 300 poster presentations contributed by graduate students, postdoctoral and medical researchers. In the past twenty years, nanomedicine and bionanotechnology have experienced remarkable advances enabled by scientific discoveries and breakthroughs. We felt that it is imperative to reiterate the significance of fundamental and transformative concepts. Thus, we place the conference theme under “Transform Nanomedicine with Breakthrough Thinking”. The meeting also includes discussion forums for Emerging Leaders and Rising Stars, aiming to stimulate provocative discussions on the most critical issues in nanomedicine and nanobiotechnology. We thank the staff members, volunteers, and session chairs for helping us build this exciting program. The organizing and scientific committees will make every effort to make sure your participation is scientifically rewarding, and your trip to Hangzhou (the Paradise on Earth) pleasurable and relaxing. Yours Sincerely, Co-Chair: Youqing Shen Co-Chair: Honggang Cui Ph.D., Professor Ph.D., Associate Professor Center for BioNanoEngineering Dept. of Chemical and Biomolecular College of Chemical and Biological Engineering Engineering Institute for NanoBioTechnology Zhejiang University, 38 Zheda ST The Johns Hopkins University Hangzhou, China 310027 3400 N. Charles Street, Baltimore, MD 21218 Phone/Fax: 86-571-87953993 Phone: 001(410) 516-6878 E-mail: [email protected] E-mail: [email protected]; http://orcid.org/0000-0003-1837-7976 http://www.jhu.edu/cui 1 欢迎辞 第四届中美纳米医学与纳米生物技术年会由中美纳米药物与纳米生物技术学会（CASNN） 主办，前三届的会议（2016，北京；2017，苏州；2018，南京）取得了巨大的成功。 第四届大会会议的主题是“推动纳米医学发展的变革性思维——Transform Nanomedicine with Breakthrough Thinking”，旨在共同探讨纳米药物/纳米医学的发展愿 景、面临的挑战及解决策略，推动纳米医学与纳米生物技术相关产业的蓬勃发展, 促进中美 纳米医学与纳米生物技术领域项目和技术的交流、合作。 会议议题 ※变革性纳米药物论坛 ※先进纳米药物/制剂与功能辅料 ※肿瘤免疫治疗的纳米药物/制剂 ※用于疾病检测的生物传感器和生物芯片 ※纳米药物的个性化治疗和临床转化 会议已邀请来自中国、美国、加拿大、日本、韩国、新加坡等国家和地区的院士和专家 及国内知名药企人员，预计参会人数约 500 人。会议将于 2019 年 8 月 19 号报到，20-22 日 在杭州举行。 我们热忱欢迎大家出席此次学术盛会！期待在各位同行的支持下，本次会议将取得圆满 成功！ 大会主席 申有青 教授 崔宏刚 教授 浙江大学 约翰霍普金斯大学 申有青 教授 崔宏刚 教授 浙江大学 约翰霍普金斯大学 2 主办单位 中美纳米医学与纳米生物技术学会（CASNN） 承办单位 浙江大学 杭州市萧山区人民政府 协办单位 萧山区委人才办 浙江大学生物质化工教育部重点实室 萧山区投资促进局 冷泉港生物科技股份有限公司 萧山科技城管理局 浙江省药学会生物制药专业委员会 化学工程国家重点实验室（浙江大学） 浙江湘湖影视文化有限公司 浙江理工大学 浙江原始资本管理有限公司 学术委员会 主任： 陈小元 美国国立卫生研究院 程建军 伊利诺伊大学 蒋兴宇 中国国家纳米科学中心 成员: 蔡林涛 中科院深圳先进技术研究院 李 春 MD 安德森癌症中心 蔡伟波 威斯康星大学麦迪逊分校 刘 滨 新加坡国立大学 陈小元 美国国立卫生研究院 刘 庄 苏州大学 程建军 伊利诺伊大学 申有青 浙江大学 崔宏刚 约翰霍普金斯大学 王 均 华南理工大学 高明远 中国科学院化学研究所 王强斌 中科院苏州纳米所 高虓虎 华盛顿大学 张 灿 中国药科大学 宫绍琴 威斯康星大学麦迪逊分校 张良方 加州大学圣地亚哥分校 顾 臻 加州大学洛杉矶分校 3 Opening and Plenary Conference Hall Opening Ceremony •Welcome Speech from Lizhong Wang, Vice President of Zhejiang University Chairs: •Welcome Speech from Xiaoshan District 08:30-09:00 •Introduction of Xiaoshan Investment Policy Youqing Shen •Introduction of Xiaoshan Science and Technology Polis •Unveiling of CASNN-Xiaoshan Center for Technology Translations Prof. Yuliang Zhao 09:00-9:30 National Center for Nanoscience and Technology CASNN Honggang Mechanisms of Nanotoxicity and Nanomedicine Cui Prof. Shuming Nie Award Youqing Lectures University of Illinois at Urbana-Champaign 9:30-10:00 Nanotechnology: from Single Molecule Raman Spectroscopy to Shen Image-Guided Cancer Surgery Opening Prof. Nicholas A. Peppas 20 Morning 20 Morning 10:00-10:40 Plenary University of Texas at Austin Yuliang Zhao Lecture Molecular Recognition at the Nanoscale Level 10:40-11:00 Coffee Break & Photographing August Prof. Paul S. Weiss University of California, Los Angeles 11:00-11:30 Adding the Chemical Dimension to Lithography at All Scales: Enabling Cellular Therapies & Other Adventures in Biology and Medicine Jianjun 11:30-12:00 Plenary Prof. Justin Hanes Cheng Lectures Johns Hopkins University Sarah Gong Nanomedicine: From Concept to Success in the Clinic 12:00-12:30 Prof. Kinam Park Purdue University PLGA Formulations: Understanding the Complexity of the PLGA Assay Lunch Prof. He Tian Chairs: 13:30-14:00 East China University of Science & Technology Dynamic Molecular Fluorescent Probes with Assembling Can Zhang Prof. Xi Zhang 14:00-14:30 Jilin University Xingyu Jiang Supramolecular Phototherapy Prof. Leaf Huang University of North Carolina at Chapel Hill 14:30-15:00 Xiaohu Gao Nanoparticles Targeting Tumor Microenvironment for Immunotherapy Plenary Dr. Pep Pàmies 15:00-15:30 Lectures Editor-in-Chief, Nature Biomedical Engineering Biomedical Engineering for Improving Human Health Dr. Fernanda Ogochi Prof. Kinam Park, EIC of JCR August 20 Afternoon 15:30-16:00 Executive Publisher,Elsevier Youqing Shen How to Get Published in High Impact Journals, Perspectives of the Editor and the Publisher Dr. Fuyao Zhang Shanghai Selection Bioscience Ltd. Co. 16:00-16:30 Enabling Platform for Transforming and Developing Nanomedicines 16:30-16:40 Coffee Break Session I: New Frontiers Session II: Therapeutics I Session III: Therapeutics II (Conference Hall A) (Conference Hall B) (Conference Room) Chairs: Xinyuan Zhu Chairs: Yi Hong Chairs: Yezi You Xintao Shuai Yong Wang Yongming Chen Xiongbin Lu Jie Zheng Qiang Zhang Indiana University University of Texas at Dallas Peking University Precision Medicine for Treating Triple 16:40-17:00 Renal Clearable Nanomedicines: Cellular Trafficking and Bioresponse of Negative Breast Cancer with From Fundamentals to Applications Nanomedicines Chromosome 17P Loss Kanyi Pu Yongzhuo Huang Nanyang Technological University Ling Peng Shanghai Instit. of Materia Medica, CAS Aix-Marseille University Molecular Optical Reporters for Targeting Tumor-Associated 17:00-17:20 Self-Assembling Supramolecular Ultrasensitive Afterglow Imaging Macrophage and Metablism as “Two- Dendrimers for Biomedical Applications and Early Diagnosis birds-One-stone" Therapeutic Strategy Ke Zhang Yongming Chen Northeastern University Yong Wang Sun Yat-Sen University Penn State University Making Oligonucleotides Better Molecular Bottlebrush as an 17:20-17:40 In Situ Nanomanufacturing on the Surface Biopharmaceuticals with Brush Unimolecular Vehicle for of Live Cells Polymers Nanomedicine August 20 Afternoon Yezi You Bing Xu Yi Hong Univ. of Science & Technology of China Brandeis University University of Texas at Arlington High Gene-Transfection Efficacy Using 17:40-18:00 Enzyme-Instructed Self-Assembly of Biodegradable Nanoparticles Enhancing Phenylboronate Micelles with Highly Peptide Nanofibers Bioadhesive Strength Selective Membrane Destruction 18:00-19:00 Dinner (Grand New Century Hotel) Poster Exhibition 19:00-21:30 Poster Award Selection Session I: New Frontiers Session II: Immunotherapy Session III: Diagnostics (Conference Hall A) (Conference Hall B) (Conference Room) Chairs: Chunying Chen Chairs: Xun Sun Chairs: Zhimou Yang Minglin Ma Hao Cheng Zhihong Nie Baran D. Sumer Gang Zheng Guanghui Ma UT Southwestern Medical Center University of Toronto & Princess Institute of Process Engineering, CAS Margaret Cancer Centre Targeting Acidosis in Cancer: A New 08:00-08:20 Bridging Systemic and Gastrointestinal Strategy Using a pH Transistor Nanoprobe Multifunctionality in Clinical Immune Responses for Enhanced Nanomedicine: Less is More? for Fluorescence-Guided Surgery in Vaccinations Humans Liqin Xiong Zhen Gu Yaping Li Shanghai Jiao Tong University University of California, Los Angeles Shanghai Institute of Materia Medica, CAS Multi-Functional Polymer Dots for 08:20-08:40 Glucose-Responsive Insulin and Enhanced Antitumor Activity of Icb Imaging of the Lymphatics, Adipose, and Delivery Devices Immunotherapy with in Situ Nanovaccines Nerves in Living Mice/Rats Minglin Ma Cornell University Hao Cheng Zhihong Nie Drexel University Fudan University 08:40-09:00 Toroidal Microgels and Their Applications for Type 1 Diabetes Cell Nanomaterials for Inducing Antigen- Engineering of Hybrid Nanovesicles for Replacement Therapies Specific Immune Tolerance Cancer Theranostics 21 Morning Chunying Chen National Center for Nanoscience and Xun Sun Zhimou Yang Sichuan University Nankai University 09:00-09:20 Technology Roles of the Protein Corona in Lymph Node Targeting for Improved Enzyme Instructed Peptide Folding, Self- Potency of Cancer Vaccine Assembly and Bioactivity Nanomedicine August Yucai Wang Changyou Zhan Qigang Wang Univ. of Science & Technology of China Fudan University Tongji University 09:20-09:35 Bio-Interfaces