2015 Harvard Chinese Life Science Symposium Harvard Chinese Life Science Annual Research Symposium March 28, 2015 Jimmy Fund Auditorium, Harvard Medical School, 35 Binney Street, Boston, MA, 02115 Harvard Medical School Chinese Scholars & Scientists Association Harvard School of Public Health Chinese Students & Scholars Association 1 2015 Harvard Chinese Life Science Symposium Organizing Committee Advisors Xi He, Professor, Boston Children’s Hospital, Harvard Medical School Xiaole Shirley Liu, Professor, Dana-Farber Cancer Institute, Harvard School of Public Health Yi Zhang, Professor, Boston Children’s Hospital, Harvard Medical School Jiping Wang, Assistant Professor, Brigham and Women’s Hospital, Harvard Medical School William Pu, Professor, Boston Children’s Hospital, Harvard Medical School Jean Zhao, Associate Professor, Dana-Farber Cancer Institute, Harvard Medical School Jing Ma, Associate Professor, Brigham and Women’s Hospital, Harvard School of Public Health Frank Hu, Professor, Harvard School of Public Health Jianzhu Chen, Professor, Massachusetts Institute of Technology Organizing Committee Harvard Medical School - Chinese Scientists and Scholars Association (HMS-CSSA) Jin Zhang, Shaokun Shu, Zhe Ji, Qing Li, Shaojun Tang, Zhiqiang Lin, Dongpo Cai, Xiaofeng Wang, Wei Li, Tengfei Xiao, Chunxiao Yu, Xingxing Kong, Min Tan, Chunyao Wei, Wen Chen, Jiaren Liu, Ji Li, Hao Huang, Jun Huang, Hongguang Xia, Xiaoyang Zhang, Wenqing Cai, Xuezhe Han, Bin Li, Yu Qian, Dapeng Yan, Yiying Zhu, Song Yang; Sui Wang Harvard School of Public Health - Chinese Students and Scholars Association (HSPH-CSSA) Zhaozhong Zhu, Qian Di, Yinyin Xu, Xihao Li, Xiaoyu Li, Haiyue Zhang 2 2015 Harvard Chinese Life Science Symposium Agenda 9:00am – 9:30am Registration and Light Refreshment Opening Remarks Dr. Edward Benz 9:30 am – 9:45 am President and CEO, Dana-Farber Cancer Institute, Harvard Medical School (Facilitator: Dr. Jin Zhang) Technology Innovation Drives Development in Medicine (Facilitator: Drs. Shirley Liu and Xi He) Life at the Single Molecule Level 9:45 am – 10:25 am Dr. Xiaoliang Xie Mallinckrodt Professor, Department of Chemistry & Chemical Biology, Harvard University Understanding active demethylation and SCNT through tool development 10:25 am – 11:05 am Dr. Yi Zhang Professor, Boston Children’s Hospital, Harvard Medical School, Investigator, Howard Hughes Medical Institute Genome Editing Technologies and Applications 11:05 am – 11:45 pm Dr. Feng Zhang Assistant Professor, Broad Institute, Massachusetts Institute of Technology DNA probes for highly multiplexed super-resolution imaging 11:45 pm – 12:25 pm Dr. Peng Yin Associate Professor, Wyss Institute, Harvard Medical School 12:25 pm - 1:30 pm Lunch (Location: Yawkey Building dinning pavilion 3rd floor) Cancer Research (Facilitator: Dr. Jiping Wang) 3 2015 Harvard Chinese Life Science Symposium A perspective in immune modulation therapy of cancer 1:30 pm – 2:10 pm Dr. Lieping Chen Professor, Yale University Director, Cancer Immunology Program at Yale Cancer Center Targeting the PI3K/PTEN pathway in cancer: from mouse genetics to human therapies 2:10 pm – 2:50 pm Dr. Jean Zhao Associate Professor, Dana-Farber Cancer Institute, Harvard Medical School 2:50 pm – 3:20 pm Distinguished Research Award Winner Talk 3:20 pm – 3:35 pm Tea Break Translational Medicine (Facilitator: Dr. William Pu) Update on use of gene therapy for monogenic diseases: the bad, the good and the future 3:35 pm – 4:15 pm Dr. David Williams Professor, Director of Translational Medicine, Boston Children’s Hospital, Harvard Medical School Viral Vector-Based In Vivo Gene Therapy 4:15 pm – 4:55 pm Dr. Guangping Gao Professor, University of Massachusetts Medical School 4:55 pm – 5:25 pm Distinguished Research Award Winner Talk 2015 Harvard Chinese Life Science Distinguished Research 5:25 pm – 5:50 pm Award Ceremony (Dr. Xi He) 6:15 pm – 9:00 pm Reception (Invited only) 4 2015 Harvard Chinese Life Science Symposium Speakers Dr. Edward J. Benz Jr. President and Chief Executive Officer of Dana-Farber Cancer Institute Dr. Benz is the Chief Executive Officer of Dana-Farber/Partners Cancer Care, Principal Investigator and Director of the Dana-Farber/Harvard Cancer Center, Director of the Dana Farber/Brigham and Women’s Cancer Center, and a member of the Governing Board of the Dana- Farber/Boston Children's Cancer and Blood Disorders Center. He is also the Richard and Susan Smith Professor of Medicine, Professor of Pediatrics, Professor of Genetics and Faculty Dean Emeritus for Oncology at Harvard Medical School. An internationally recognized hematologist, Dr. Benz has authored more than 300 peer-reviewed articles, reviews, chapters, and abstracts. His accomplishments have been recognized by a number of distinctions, including membership in the Institute of Medicine of the National Academy of Sciences, the Association of American Physicians, and the American Academy of Arts and Science. Dr. Benz is a graduate of Princeton University and Harvard Medical School. He received his training in internal medicine and hematology at Brigham and Women's Hospital, the Children’s Hospital of Boston, the National Institutes of Health, and the Yale University School of Medicine. Dr. Xiaoliang Xie Mallinckrodt Professor, Department of Chemistry & Chemical Biology, Harvard University Member of the National Academy of Sciences Xiaoliang Sunney Xie received a B.S. from Peking University in 1984, and his Ph.D. from the University of California at San Diego in 1990, followed by a short postdoctoral experience at the University of Chicago. In 1992, Xie joined Pacific Northwest National Laboratory, where he later became a Chief Scientist. In 1999, he was appointed Professor of Chemistry at Harvard University. He is now the Mallinckrodt Professor of Chemistry and Chemical Biology at Harvard, and the Cheung Kong Visiting Professor at Peking University, Biodynamics Optical Imaging Center (BIOPIC). Xie has made major contributions to the emergence of the field of single-molecule biophysical chemistry and its application to biology. His team also pioneered the development of coherent Raman scattering microscopy and single cell whole genome sequencing. His honors include the Harrison Howe Award, Biophysical Society Founders Award, E.O. Lawrence Award in Chemistry, Leibinger Innovation Prize, the NIH Director's Pioneer Award, the Sackler Prize for Physical Sciences. Xie is a fellow of the American Academy of Arts and Sciences and a member of the National Academy of Sciences. 5 2015 Harvard Chinese Life Science Symposium Dr. Yi Zhang Professor, Boston Children’s Hospital, Harvard Medical School Investigator, Howard Hughes Medical Institute Dr. Zhang is currently an Investigator of the Howard Hughes Medical Institute and a Fred Rosen Chair Professor of the Department of Genetics and Department of Pediatrics of the Harvard Medical School. He is also a senior Investigator of the Program of Cellular & Molecular Medicine of the Boston Children’s Hospital. Before he moved to Harvard, he was a Kenan Distinguished Professor of University of North Carolina at Chapel Hill. The major interest of Dr. Zhang is to understand the epigenetic regulation in early development, stem cell reprogramming, differentiation, and reward-related learning and memory. Dr. Zhang is also interested in how dysregulation of chromatin modifying enzymes contribute to various human diseases, such as cancer, diabetes, and drug addiction. His group contributed to the identification and characterization of several classes of epigenetic enzymes that include histone methyltransferases, JmjC-containing histone demethylases, and the Tet family of dioxygenases for DNA demethylation. Dr. Zhang was Top 10 author of high-impact papers by ScienceWatch in Genetics and Molecular Biology from 2002-2006, and is also one of the most influential scientists in the world in the past 10 years. Dr. Feng Zhang Assistant Professor, Departments of Brain and Cognitive Sciences and Biological Engineering. MIT Broad Institute of MIT and Harvard Feng Zhang is a Core Member at the Broad Institute, an investigator at the McGovern Institute for Brain Research at MIT, and the W. M. Keck Career Development Professor at MIT. His lab develops molecular technologies and applications for interrogating biological systems, with an emphasis on the nervous system and its diseases. He is widely recognized for playing a central role in the development of technologies such as optogenetics and genome editing using CRISPR-Cas9. He has also played a leading role in making molecular technology reagents and know-how openly accessible. Dr. Peng Yin Associate Professor, Harvard Medical School Core Faculty Member, Wyss Institute Dr. Yin directs the Molecular Systems Lab at Harvard. His research interests lie at the interface of information science, molecular engineering, and biology. The current focus is to engineer information directed self-assembly of nucleic acid (DNA/RNA) structures and devices, and to exploit such systems to do useful molecular work. Such de novo designed systems are composed of small synthetic DNA/RNA monomers capable of conditional configuration change and can be 6 2015 Harvard Chinese Life Science Symposium programmed to self-assemble, move, and compute. They can serve as programmable controllers for the spatial and temporal arrangements of diverse functional molecules (e.g. fluorophores, proteins), with a wide range of applications in nano-fabrication, imaging, sensing, diagnostics, and therapeutics. He is a recipient