Zug, June 16, 2021 STOXX Changes composition of Theme Indices effective on June 21, 2021 Dear Sir and Madam, STOXX Ltd., the operator of Qontigo’s index business and a global provider of innovative and tradable index concepts, today announced the new composition of STOXX Theme Indices as part of the regular quarterly review effective on June 21st, 2021. This notification cancels and replaces previous components announcement for the STOXX Theme Indices which was published on June 12th, 2021. Date Symbol Index name Internal Key ISIN Company name Changes 16.06.2021 IXAGPOPE STOXX Global Ageing Population US9KT8 VGG111961055 BIOHAVEN PHARMACEUTICAL HDG Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US9173 US09627Y1091 BLUEPRINT MEDICINES Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population VTR US92276F1003 Ventas Inc. Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population CH7022 CH0363463438 IDORSIA LIMITED Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US07YR US5270641096 LESLIES Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US9LVB US10806X1028 BRIDGEBIO PHARMA Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US9LEU US90041T1088 TURNING POINT THERAPEUTICS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population CN1N2P CNE100003PJ8 VENUS MEDTECH HANGZHOU 'H' Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US04YO US85205L1070 SPRINGWORKS THERAPEUTICS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population ZA00GP ZAE000070660 Sanlam Ltd Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population CN92FP KYG5140J1013 JINXIN FERTILITY GROUP Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population HK02DG KYG0146B1032 AKESO Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population 485283 NO0003053605 STOREBRAND Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population BR1126 BRRDORACNOR8 REDE DOR SAO LUIZ ON Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US15KC US0090661010 AIRBNB A Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US15B3 CA00288U1066 ABCELLERA BIOLOGICS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population JP205F JP3274280001 WELCIA HOLDINGS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population HCN US95040Q1040 Welltower Inc. Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population 77940 GB0002405495 SCHRODERS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population BMY US1101221083 Bristol-Myers Squibb Co. Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population AOC IE00BLP1HW54 AON PLC Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population DE3093 DE0006632003 MORPHOSYS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US06E6 US8163073005 SELECTQUOTE Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population MGLH US5590792074 Magellan Health, Inc. Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US05SJ US05465P1012 AXONICS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population KR09G0 KR7326030004 SK BIOPHARMACEUTICALS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population SE705I SE0009778848 MEDICOVER AB Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population CYH US2036681086 COMMUNITY HEALTH SYSTEMS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US13MC US39986L1098 GROWGENERATION Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population 635214 AU000000FLT9 FLIGHT CENTRE TRAVEL GP. Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US06C4 US75943R1023 RELAY THERAPEUTICS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population FI905B FI0009010912 REVENIO GROUP Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population CH103X CH0010675863 SWISSQUOTE 'R' Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US062U US38267D1090 GOOSEHEAD INSURANCE A Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US05I9 US76155X1000 REVOLUTION MEDICINES Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US9LM2 CA98985W1023 ZYMEWORKS (NYS) Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US14JA US68404L2016 OPTION CARE HEALTH Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population 21483 GB0002148343 RATHBONE BROTHERS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US94YX MU0295S00016 MAKEMYTRIP Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US06XP US00653Q1022 ADAPTHEALTH A Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population IE201Z IE00B91XRN20 PROTHENA Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US07C5 US12529R1077 C4 THERAPEUTICS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population ANAT US02772A1097 AMERICAN NATIONAL GROUP Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population TH104F TH1016010007 BANGKOK LIFE ASSURANCE Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population KR90J3 KR7268600004 CELLIVERY THERAPEUTICS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US9MQ7 US24344T1016 DECIPHERA PHARMS. Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US041R IL0011595993 INMODE Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US9HT5 US8006771062 SANGAMO THERAPEUTICS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US15ZR US09077B1044 BIOATLA Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population CN1OC0 CNE100003FF7 SH JUNSHI BIOSCIENCES 'H' Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US08LF US82024L1035 SHATTUCK LABS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US08KE US81750R1023 SERES THERAPEUTICS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US15NF US02081G2012 ALPHATEC HOLDINGS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US15VN US05589G1022 BRP GROUP A Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US060S US34633R1041 FORMA THERAPEUTICS HLDG Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US12G5 US7602731025 REPARE THERAPEUTICS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US053U US9842411095 Y MABS THERAPEUTICS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US07RK US4131971040 HARMONY BIOSCIENCES HLDG Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US9MK1 US70805E1091 PENNANT GROUP Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population ID5099 ID1000135700 MITRA KELUARGA KARYASEHAT Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US11ZN US85914M1071 STEPSTONE GROUP A Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population TW9031 TW0006670003 FUSHENG PRECISION Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US1782 US37954A2042 GLOBAL MEDICAL REIT Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US123S US87164F1057 SYNDAX PHARMACEUTICALS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US11SG US8257041090 SI BONE Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US08ZT CA89620X5064 TRILLIUM THERP. (NAS) Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population TW1AXX TW0006491004 PEGAVISION Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US066Y US59045L1061 MERSANA THERAPEUTICS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US072V US03969F1093 ARCUS BIOSCIENCES Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population 673463 SG1CH4000003 RAFFLES MEDICAL GP. Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population CA90OJ CA7005632087 PARK LAWN Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population HK02EH KYG0519B1023 ASCENTAGE PHARMA GROUP INTL. Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population KR60DU KR7039200001 OSCOTEC Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population KR04XC KR7032350001 LOTTE TOURS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US12LA US80706P1030 SCHOLAR ROCK HOLDING Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US14G7 US67080M1036 NURIX THERAPEUTICS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US14YP NL0011606264 MERUS NV Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population HK916H KYG3679P1019 FRONTAGE HOLDINGS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US13B1 US35104E1001 4D MOLECULAR THERAPEUTICS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population KR09K4 KR7298380007 ABL BIO Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US17SM US68621F1021 ORGANOGENESIS HOLDINGS A Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population TH908R TH8878010009 TQM CORPORATION Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population KR64BW KR7144510005 GREEN CROSS LABCELL Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population NO005G NO0010000045 PHOTOCURE Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population TH211E TH0295A10Z07 VIBHAVADI MEDICAL Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population SE10U1 SE0009858152 BONESUPPORT HOLDING Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population KR11LY KR7080160005 Modetour Network Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population KR90N7 KR7290650001 L&C BIO Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US99VZ US2697961082 EAGLE PHARMACEUTICALS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US15G8 US0051111096 ACUTUS MEDICAL Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US94ON IL0011407140 UROGEN PHARMA Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US13E4 US35803L1089 FREQUENCY THERAPEUTICS Addition 16.06.2021 IXAGPOPE STOXX Global Ageing Population US412T US5314651028 LIBERTY TRIP ADVI.HDG. SR.A Addition 16.06.2021