Dr. Sanjeev Kumar Singh Professor Contact Address : Department of Bioinformatics Room No. 403, 4th Floor, Science Campus Alagappa University Karaikudi – 630 004 Tamil Nadu, India Employee Number : 34301 Date of Birth : 23-08-1975 Contact Phone (Office) : +91 - 4565 223342 Contact Phone (Mobile) : +91 - 9894429800 Contact e-mail(s) : [email protected] Website : www.sanjeevslab.org Academic Qualifications: M.A./M.Sc./M. Phil. /Ph.D. / Year Degree Subject University/Institute 2004 Ph. D. Applied Chemistry CSJM University, Kanpur 2000 M. Sc. Life Sciences Institute of Life Sciences, CSJM University, Kanpur 1998 B. Sc. Zoology, Botany, Chemistry Christ Church College, CSJM University, Kanpur Teaching Experience: 18 Years Research Experience: 18 Years Designation Name of Employer Period No. of Years From To /Months Professor Dept. of Bioinformatics 20th March, Continue 4 years Alagappa University 2015 Karaikudi, Tamil Nadu Associate Professor Dept. of Bioinformatics 20th March, 19th March, 3 years Alagappa University 2012 2015 Karaikudi, Tamil Nadu Reader Dept. of Bioinformatics 20th March, 19th March, 3 years Alagappa University 2009 2012 Karaikudi Lecturer CoE in Bioinformatics, 31st March, 19th March, 3 years School of Biotechnology, 2006 2009 Madurai Kamaraj University Scientist-II Pharmacoinformatics Division, June, 30 March, 1 year 9 NIPER, Mohali 2004 2006 months Senior Research Fellow Dept. of Chemistry, IET, CSJM 18 Nov, May, 1 year 6 University, Kanpur 2002 2004 months Junior Research Fellow Dept. of Chemistry, 18 Nov, 17 Nov, 2 years IET, CSJM University, Kanpur 2000 2002 Additional Responsibilities Responsibility in University/Community Services Rashtriya Uchchatar Shiksha Abhiyan (RUSA) Coordinator at Alagappa University. Nodal Officer for Niti Aayog – Grant in aid schemes for CSOs/NGOs/VOs in State Government at Alagappa University. Special Officer (Projects) at Alagappa University from Dec 2017 – Jan 2019. Deputy Coordinator for Rashtriya Uchchatar Shiksha Abhiyan (RUSA) at Alagappa University. Special Officer (For Funding Agencies) at Alagappa University (Sep. - Dec. 2017). Secretary General – Bioinformatics and Drug Discovery Society (BIDDS), Feb. 2017. Deputy Coordinator, DST-FIST Program (Level-I) at Department of Bioinformatics, Alagappa University (2017). Department Coordinator of UGC-NAAC at Department of Bioinformatics, Alagappa University (2016). Co-ordinator from Alagappa University for “Ek Bharat Shreshta Bharat” Scheme initiated by the Ministry of Human Resource and Development (Govt. of India). Responsibility in Corporate Life Invited for lecture and training in personality development at Department of Bank Management, Alagappa University, Karaikudi. Invited for lecture and training in personality development at Bharthidasan University, Trichy. Nominated as the inspection team member for affiliation DDE Centre’s: Kurinji College of Arts and Science, Gateway for Entrepreneurship and Management Studies Trust, Trichy. Dharmapuram Adhinam Arts College, Sree Radhaa Krishna Educational Trust, Mayiladuthurai. Shri APM Trust, Thuraiyur, Trichy. Areas of Research Our group focuses on the Computational Drug Design and Structural Bioinformatics approaches of various therapeutic targets like HIV-1 Protease, Integrase, Reverse Transcriptase, Human Papillomavirus, ZIKA, Dengue, Chikungunya, Cyclin Dependent Kinases, Histone Acetyl Transferase (HAT). We mainly concentrate on the development of novel therapeutics from basic research to the molecular level for the study of interactive small molecule inhibitors with the biological targets along with exploration and designing of pharmacologically relevant molecules which can act as potent inhibitors of the various targets. Our research includes extensive in-silico approaches including Molecular Modelling, Structural Bioinformatics and Computational Biology etc. Our energetic environment of team work is focused to gain the experience and knowledge for developing research strategies to support current drug discovery. Research Supervision / Guidance Program of Study Completed Ongoing Research Ph.D. 04 07 Post Doc 01 - M.Phil. 07 01 Project PG 34 - UG / Others 08 - Publications International Journals National Journals Book Chapters 115 03 15 Cumulative Impact Factor (as per JCR) : 252.947 h-index : 17 i10 index : 31 Total Citations : 924 Funded Research Projects Completed Projects S. Agency Period Project Title Budget No (Rs. In From To lakhs) DBT-Twin, 2014 2018 Identification of novel drug targets of 73.69 1 New Delhi Leishmania donovani: Studies on CAAX prenyl protease I and II of the pathogen CSIR, 2012 2015 QM/MM partial charges, binding pocket 16.02 New Delhi contours analysis and FEP calculation for 2 designing potent inhibitors of HTLV- Protease: A De novo drug design approach DST , New 2011 2014 Computational Screening of CDK2 inhibitors by 18.95 Delhi combined approach of pharmacophoric study, 3 Quantum polarized ligand docking and molecular dynamics simulation study UGC 2011 2014 Shape and chemical feature based 3D- 7.48 (major) Pharmacophore Model generation, Virtual 4 New Delhi Screening and MESP studies to identify Potential Leads for Antifungal Azoles. AURF 2009 2012 Pharmacophoric Analysis and designing of ATP 4.00 (UGC) competitive CDK 4 inhibitors. 5 with NIBI, Osaka Ongoing Projects S. Agency Period Project Title Budget (Rs. No. From To In lakhs) 1 DBT New 2016 2019 In-Silico screening, theoretical calculation and in 19.51 Delhi vitro studies for development of potential HIV1-PR inhibitors Projects in Review Process Understanding the switch between autophagy and 1 1 apoptosis mediated through cleavage of ATG5 and Department of Rs. 165.04 Under review ATG4D in different types of cancer and Biotechnology Lakh process development of novel lead anti-cancerous (DBT)-TWIN, Delhi molecule(s). In silico design, in vitro and in vivo characterization 2 Rs. of small molecule inhibitors for repressor proteins INDO-SWISS, Under review 198.00 and peptide analogs of Tat to rekindle the viral DBT process Lakh transcription Design of host targeted inhibitors against HIV and INDO-RUSSIA, Rs. 131.67 Under review 3 Influenza viruses. DST Lakh process Investigation on various viral targets, an expanding Tamil Nadu Rs. 4 Under review threat to the public health: a combined in silico and Innovation 136.48 Initiatives (TANII) Lakh process in vitro approach. Rashtriya 5 Mechanistic insights to understand the virus-host Uchchatar Under review interaction and the identification of next generation 85.99 Shiksha Abhiyan process drugs to combat ZIKV infection. (RUSA) 2.0 Design, synthesis and delivery of NCE for Mutated Under review 6 DBT-ATGC 188.33 TP53 as targeted chemotherapy agents. process Design, synthesis and validation of modulators in 7 Under review regulating GPCR and insights about the dynamic INDO-AUS 2798.00 process changes against neurodegenerative diseases. Patents Nil Distinctive Achievements / Awards Biotech Research Society, India (BRSI) Fellow Award – 2018 from the Biotech Research Soceity, India for his outstanding contribution in the area of Structural Bioinformatics and Computer Aided Drug Design. ICMR Lala Ram Chand Kandhari Award-2014 from the Indian council of Medical Research, New Delhi, India for outstanding contribution in the field of Sexually Transmitted Diseases and HIV. Senior Scientist Award-2017 from the Association of Biotechnology and Pharmacy (ABAP), Hyderabad, Telangana, India for immense contribution in the field of Computational Drug Discovery and development of novel inhibitors for treating HIV/AIDS. Elected Member for The National Academy of Sciences, Allahabad, India (MNASc) in May 2017. Dr. P. Daisy Oration Award-2017 from the Department of Zoology, Biotechnology and Bioinformatics, Holy cross College, Tiruchirapalli, Tamil Nadu, India for outstanding contribution in the life threatening diseases like Cancer and HIV. Secretary General – Bioinformatics and Drug Discovery Society (BIDDS), from Feb., 2017 for three years. Council for Scientific and Industrial Research (CSIR) Travel Award: To present paper in “Albany 2015: The 19th Conversation” held at Department of Chemistry, University at Albany, New York, USA. Indian Council of Medical Research (ICMR) Travel Award: To present paper in 11th European conference on Computational Biology (ECCB’12) at Basel, Switzerland (2012). Department of Science and Technology (DST) Travel Award: To present paper in “Albany 2011: 17th Conversation at University of Albany, USA (2011). DST Fast Track grant for Young Scientist-2010 in Chemical Science. Department of Biotechnology (DBT) Travel Award: To present a paper in IDDST-2007 in Xian, China (2007). Achievements by Prof. Sanjeev Kumar Singh’s Students Sunil Kumar Tripathi,(Student) CSIR-SRF Award -2012 in Bioinformatics Chandrabose Selvaraj (Student) Asia Pacific Bionetwork and Bioclues Travel Award- 2012 to work in A-Star institute at Singapore for one month. Chandrabose Selvaraj (Student) BIRD -Special Mention Award-2012. Venkatesan Suryanarayanan (Student) DST-Inspire Fellowship Award – 2012. Karnati Konda Reddy (Student) CSIR –SRF Award -2013 in Bioinformatics. KK Reddy ICMR travel grant to present paper in ISMB/ECCB conference in Berlin, Germany, 2013. Umesh Panwar (Student) Alagappa University Research Fellowship (AURF - 2015- 2017). Umesh Panwar (Student) Indian Council of Medical Research (ICMR - 2018-2020). Aarthy M. (Student) Rajiv Gandhi National Fellowship (RGNF) - UGC - (2015-2020). Aarthy M. (Student)