US010265349B2 (12 ) United States Patent ( 10 ) Patent No. : US 10 , 265 ,349 B2 Chatila et al. (45 ) Date of Patent: Apr. 23 , 2019 ( 54 ) THERAPEUTIC MICROBIOTA FOR THE (56 ) References Cited TREATMENT AND /OR PREVENTION OF FOOD ALLERGY U . S . PATENT DOCUMENTS 5 , 225 , 202 A 7 / 1993 Hodges ( 71) Applicants : THE BRIGHAM AND WOMEN ' S 5 , 733 ,575 A 3 / 1998 Mehra HOSPITAL , INC . , Boston , MA (US ) ; 5 , 951 ,977 A 9 / 1999 Nisbet CHILDREN ' S MEDICAL CENTER 6 , 139 , 875 A 10 /2000 Adams 6 ,420 ,473 B1 7 / 2002 Chittamuru CORPORATION , Boston , MA (US ) 6 ,455 ,052 B1 9 / 2002 Marcussen 6 , 569, 457 B2 5 /2003 Ullah (72 ) Inventors : Talal A . Chatila , Belmont, MA (US ) ; 8 , 460, 648 B2 6 / 2013 Borody 8 ,486 ,668 B2 7 / 2013 Ritter Lynn Bry , Jamaica Plain , MA (US ); 9 ,011 , 834 B1 4 / 2015 McKenzie et al . Georg Gerber , Boston , MA (US ) ; Azza 9 ,408 , 872 B2 8 / 2016 Borody Abdel -Gadir , Boston , MA (US ) ; Rima 9 , 433 ,652 B2 9 / 2016 Honda et al . 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A61K 35 / 742 (2013 . 01 ) ; A61K 9 /0053 Disclosed are methods and compositions for the prevention (2013 .01 ) ; A61K 35 / 74 ( 2013 .01 ) ; A61K and treatment of food allergy . In particular, described herein 35 / 741 (2013 . 01 ) ; A61K 35/ 744 ( 2013 . 01 ) ; are microbial consortia , including minimal microbial con A61K 35 / 745 (2013 .01 ) ; A61K 45 / 06 sortia , that can prevent and/ or cure food allergy . In certain ( 2013 . 01 ) ; A61P 37 / 08 ( 2018 .01 ) ; A61K 9 / 19 embodiments , the consortia comprise certain members of (2013 . 01 ) ; YO2A 50/ 473 (2018 .01 ) the taxa Clostridiales and /or Bacteroidetes. (58 ) Field of Classification Search None See application file for complete search history . 27 Claims, 52 Drawing Sheets US 10 , 265 ,349 B2 Page 2 References Cited Open Biome FMT capsules F30 and G3: available on the web at (56 ) openbiome. org / fmtcapsules / . 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