S EPIDEMIOLOGY OF E I T I SKIN TUMOR ENTITIES T N ACCORDING TO THE NEW WHO E R CLASSIFICATION O M IN DOGS AND CATS U T N I K S F O Monier A. Mohamed Sharif Y G O L O I M E D I P E F I R A H S INAUGURAL-DISSERTATION R E zur Erlangung des Grades eines I Dr. med. vet. N beim Fachbereich Veterinärmedizin édition scientifique O VVB LAUFERSWEILER VERLAG der Justus-Liebig-Universität Gießen M VVB LAUFERSWEILER VERLAG ISBN 3-8359-5055-X STAUFENBERGRING 15 D-35396 GIESSEN Tel: 0641-5599888 Fax: -5599890 [email protected] www.doktorverlag.de 9 7 8 3 8 3 5 9 5 0 5 5 9 édition scientifique VVB VVB LAUFERSWEILER VERLAG Das Werk ist in allen seinen Teilen urheberrechtlich geschützt. Jede Verwertung ist ohne schriftliche Zustimmung des Autors oder des Verlages unzulässig. Das gilt insbesondere für Vervielfältigungen, Übersetzungen, Mikroverfilmungen und die Einspeicherung in und Verarbeitung durch elektronische Systeme. 1. Auflage 2006 All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior written permission of the Author or the Publishers. 1st Edition 2006 © 2006 by VVB LAUFERSWEILER VERLAG, Giessen Printed in Germany VVB LAUFERSWEILER VERLAG édition scientifique STAUFENBERGRING 15, D-35396 GIESSEN Tel: 0641-5599888 Fax: 0641-5599890 email: [email protected] www.doktorverlag.de Aus Institut für Veterinär-Pathologie der Justus-Liebig-Universität Giessen Betreuer: Prof. Dr. Manfred Reinacher, Geschäftsführender Direktor des Institut für Veterinär-Pathologie der Justus-Liebig-Universität Giessen EPIDEMIOLOGY OF SKIN TUMOR ENTITIES ACCORDING TO THE NEW WHO CLASSIFICATION IN DOGS AND CATS INAUGURAL-DISSERTATION zur Erlangung des Grades eines Dr. med. vet. beim Fachbereich Veterinärmedizin der Justus-Liebig-Universität Gießen eingereicht von Monier A. Mohamed Sharif Tierarzt aus Baida-Libyen Gießen 2006 Mit Genehmigung des Fachbereichs Veterinärmedizin der Justus-Liebig-Universität Gießen Dekan: Prof. Dr. Manfred Reinacher Gutachter: Prof. Dr. Manfred Reinacher Gutachterin: PD Dr. C. Pfarrer Tag der Disputation: 26.06.2006 To the memory of my father ﺍﻟﻰ ﺭﻭﺡ ﺍﻟﻮﺍﻟﺪ ﺍﻟﻌﺰﻳﺰ, ﺍﻟﻠﻬﻢ ﺍﻏﻔﺮ ﻟﻪ ﻭ ﺍﺭﺣﻤﻪ . I CONTENTS 1. INTRODUCTION..............................................................................................................1 2. LITERATURE REVIEW ...................................................................................................2 2.1. World Health Organization (WHO) classification of tumors of domestic animals ........2 2.2. General population.......................................................................................................2 2.2.1. Dogs .....................................................................................................................3 2.2.2. Cats.......................................................................................................................3 2.3. Anatomical division.....................................................................................................4 2.4. Tumor statistic .............................................................................................................4 2.4.1. Tissue of origin .....................................................................................................4 2.4.2. Prevalence of individual types of skin tumors........................................................5 2.4.2.1. Tumors in dogs...............................................................................................5 2.4.2.1.1. Sex predilection.......................................................................................6 2.4.2.1.2. Anatomical location.................................................................................7 2.4.2.1.3. Breed disposition .....................................................................................7 2.4.2.1.4. Age distribution .......................................................................................8 2.4.2.2. Tumors in cat .................................................................................................8 2.4.2.2.1. Sex predilection.......................................................................................9 2.4.2.2.2. Anatomical location.................................................................................9 2.5. Skin tumors................................................................................................................10 2.5.1. Epithelial and melanocytic tumors of the skin .....................................................10 2.5.1.1. Epithelial tumors without squamous or adnexal differentiation .....................10 2.5.1.1.1. Basal cell tumors (basal cell epithelioma) ..............................................10 2.5.1.1.2. Basal cell carcinoma ..............................................................................13 2.5.1.1.2.1. Infiltrative basal cell tumor .............................................................13 2.5.1.1.2.2. Clear cell basal cell tumor...............................................................13 2.5.1.2. Tumors of the epidermis...............................................................................13 2.5.1.3. Tumors with adnexal differentiation.............................................................14 2.5.1.3.1. Follicular tumors ...................................................................................14 2.5.1.3.1.1 Infundibular keratinizing acanthoma ................................................14 2.5.1.3.1.2 Tricholemmoma...............................................................................14 2.5.1.3.1.3 Trichoblastoma ................................................................................15 2.5.1.3.1.4 Trichoepithelioma............................................................................16 2.5.1.3.1.5 Pilomatricoma..................................................................................16 2.5.1.3.2. Nailbed tumors ......................................................................................16 2.5.1.3.3. Sebaceous and modified sebaceous gland tumors...................................17 2.5.1.3.4. Apocrine and modified apocrine gland tumors.......................................17 2.5.1.3.5. Eccrine (atrichial) tumors.......................................................................18 2.5.1.4. Tumors metastatic to the skin .......................................................................18 2.5.1.5. Cysts ............................................................................................................18 2.5.1.5.1. Dermoid cyst .........................................................................................19 2.5.1.5.2. Epidermal cyst.......................................................................................19 2.5.1.5.3. Follicular cyst........................................................................................20 2.5.1.5.4. Apocrine cyst.........................................................................................20 2.5.1.5.5. Sebaceous duct cyst ...............................................................................20 2.5.1.5.6. Matrical cyst..........................................................................................20 2.5.1.5.7. Cyst with epithelial proliferation............................................................21 2.5.1.5.8. Cysts with precarcinomatous epithelial transformation ..........................21 II 2.5.1.5.9. Branchial cyst........................................................................................21 2.5.1.5.10. Subungual epithelial inclusion cyst ......................................................21 2.5.1.5.11. Dilated pore.........................................................................................22 2.5.1.5.12. Isthmus cyst.........................................................................................22 2.5.1.5.13. Panfollicular cyst .................................................................................22 2.5.1.5.14. Ciliated cyst.........................................................................................22 2.5.1.6. Hamartomas .................................................................................................23 2.5.1.7. Tumor-like lesions........................................................................................23 2.5.1.7.1. Squamous papilloma..............................................................................23 2.5.1.7.2. Pressure point comedones......................................................................24 2.5.1.7.3. Cutaneous horn......................................................................................24 2.5.1.7.4. Warty dyskeratoma................................................................................24 2.5.1.7.5. Sebaceous hyperplasia ...........................................................................24 2.5.1.7.6. Fibroepithelial "polyp"...........................................................................25 2.5.1.7.7. Fibropruritic nodule...............................................................................25 2.5.1.8. Melanocytic tumors......................................................................................25 2.5.1.8.1. Melanocytoma and Malignant melanoma...............................................25 2.5.1.8.2. Melanoacanthoma..................................................................................25