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PATENT DOCUMENTS ( 74 ) Attorney , Agent, or Firm — KPPB LLP 2001/ 0041362 A1 * 11 / 2001 Taniguchi .. .. CO7K 14 /55 435 /325 (57 ) ABSTRACT FOREIGN PATENT DOCUMENTS Embodiments of the present invention provide diagnostic WO 2006012507 A2 2 / 2006 markers of immunosenescence and methods of identifying WO 2009134944 A2 11 / 2009 individuals with impaired immune function based on a WO 2010006291 A1 1 /2010 combination of such markers obtained from various ana lyzes , primarily from blood , testing immune function includ OTHER PUBLICATIONS ing the analysis of immune cell subset frequencies , gene Hann et al. ( Cellular Signalling , 2005 , 17 : 1542 - 1550 ). * expression , cytokine and chemokine levels , and signaling Wikby et al . (Biogerontology , 2008 , 9 : 299 -308 ) . * responses to stimulation with cytokines (* cytokine Krutzik et al. (Nature Methods, May 2006 ; vol. 3 , Nol. 5 , pp . response ’ ) . 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