TABLE S3 "ID ""Description"" ""GeneRatio"" ""BgRatio"" ""pvalue"" ""p.adjust"" ""qvalue"" ""geneID"" ""Count""" "GO:0060485 ""GO:0060485"" ""mesenchyme development"" ""57/1866"" ""269/23239"" 9.4636789495672e-12 5.38861879388356e-08 4.37819673508925e-08 ""Bmpr2/Erbb4/Clasp1/Mdm4/Adipor1/Cited2/Hdac2/ Gja1/Kitl/Pawr/Hnrnpab/Anxa6/Tmem100/Ddx5/Axin2/Osr1/Zfp36l1/Mef2c/ Fgf9/Gata4/Ddx17/Hes1/Sema5b/Phldb2/Robo2/Tiam1/Erg/Sox8/Bambi/ Ldlrad4/Smad7/Pax2/Nckap1/Wt1/Sema6d/Il1b/Pax1/Fam83d/Sema6c/Sdcbp/ Trim62/Sema3c/Coro1c/Tbx5/Smo/Dact3/Sema4b/Wnt11/Folr1/Tead1/Dand5/ Nup133/Yap1/Sema7a/Nedd4/Clasp2/Ctnnb1"" 57" "GO:0016570 ""GO:0016570"" ""histone modification"" ""70/1866"" ""422/23239"" 4.63618683746812e-09 1.12414845920283e-05 9.13358933354856e-06 ""Zfp451/Trip12/Rbbp5/Smyd3/Hdac2/Sirt1/Jmjd1c/ Yeats4/Usp15/Cdk2/Lif/Srebf1/Aurkb/Kdm6b/Suz12/Atxn7l3/Wbp2/Hdac9/ Prkd1/Brms1l/Arid4a/Jdp2/Arid4b/Hist1h1c/Atxn7/Usp16/Brpf3/Kat2b/Mta3/ Epc1/Wac/Kdm3b/Kmt5b/Kdm2a/Suv39h2/Bmi1/Ehmt1/Wdr5/Rif1/Eid1/Ncoa6/ Phf20/Zfp335/Jade1/Ash1l/Setdb1/Eya3/Paxip1/Rest/Mtf2/Sart3/Kdm2b/ Kdm7a/Prdm5/Kdm3a/Ruvbl1/Rybp/Sgf29/Setd1a/Sin3b/Pkn1/Taf5l/Morf4l1/ Msl2/Wdr82/Ctnnb1/Hdac6/Jade3/Tbl1x/Phf8"" 70" "GO:0016569 ""GO:0016569"" ""covalent chromatin modification"" ""71/1866"" ""433/23239"" 5.92280536987791e-09 1.12414845920283e-05 9.13358933354856e-06 ""Zfp451/Trip12/Rbbp5/Smyd3/Hdac2/Sirt1/Jmjd1c/ Yeats4/Usp15/Cdk2/Lif/Srebf1/Aurkb/Kdm6b/Suz12/Atxn7l3/Wbp2/Dnmt3a/ Hdac9/Prkd1/Brms1l/Arid4a/Jdp2/Arid4b/Hist1h1c/Atxn7/Usp16/Brpf3/ Kat2b/Mta3/Epc1/Wac/Kdm3b/Kmt5b/Kdm2a/Suv39h2/Bmi1/Ehmt1/Wdr5/Rif1/ Eid1/Ncoa6/Phf20/Zfp335/Jade1/Ash1l/Setdb1/Eya3/Paxip1/Rest/Mtf2/ Sart3/Kdm2b/Kdm7a/Prdm5/Kdm3a/Ruvbl1/Rybp/Sgf29/Setd1a/Sin3b/Pkn1/ Taf5l/Morf4l1/Msl2/Wdr82/Ctnnb1/Hdac6/Jade3/Tbl1x/Phf8"" 71" "GO:0061564 ""GO:0061564"" ""axon development"" ""76/1866"" ""483/23239"" 1.10467424874716e-08 1.57250379309158e-05 1.27764297980099e-05 ""Trak2/Bmpr2/Actr3/Cxcr4/Enah/Ust/Plxnc1/Fstl4/ Rtn4rl1/Rab10/Nrcam/Sipa1l1/Flrt2/Mtr/Ptch1/Zswim6/Vcl/Atp8a2/Fzd3/ Dpysl2/Slitrk1/Slitrk5/Stk24/Kalrn/Sema5b/Robo2/App/Tiam1/Ddr1/ Hsp90ab1/Ptprm/Nrep/Myo5b/Rnf165/Ablim1/Shtn1/Kif5c/Sema6d/Adnp/Skil/ Sema6c/Ngf/Plppr4/Epha7/Klf4/Trim32/Nfib/Jun/Sema3c/Nkx6-1/Ssh1/ Ptpn11/Actb/Smo/Ctnna2/Plxna1/Arhgap35/Igf1r/Sema4b/Picalm/Folr1/ Unc5d/Nrg1/Rab3a/Pou4f2/Tubb3/Disc1/Nectin1/Zpr1/Sema7a/Rab11a/Clasp2/ Trak1/Hdac6/Xk/Pak3"" 76" "GO:1903311 ""GO:1903311"" ""regulation of mRNA metabolic process"" ""46/1866"" ""241/23239"" 2.92835523104614e-08 3.15705416537512e-05 2.56507367992599e-05 ""Gigyf2/Dhx9/Rc3h1/Hnrnpu/Larp1/Cnot8/Srsf1/ Ddx5/Axin2/Srsf2/Zfp36l1/Zc3h14/Hnrnpk/Ddx17/Tnrc6b/Wtap/Srsf7/ Zfp36l2/Celf4/Malat1/Cpeb3/Celf2/Fxr1/Noct/Dhx36/Mov10/Rbm15/Mettl14/ Virma/Pabpc4/Srsf10/Srpk2/Rest/Cnot6l/Hnrnpd/Sart3/Rbm19/Zc3hav1/Tia1/ Dhx34/Supt5/Samd4b/Hnrnpl/Cnot7/Rbmxl1/Sltm"" 46" "GO:0071560 ""GO:0071560"" ""cellular response to transforming growth factor beta stimulus"" ""40/1866"" ""200/23239"" 6.14982587855302e-08 3.89078983916454e-05 3.16122628494041e-05 ""Zfp451/Bmpr2/Actr3/Cited2/ Ptprk/Fyn/Sirt1/Usp15/Mtmr4/Ppm1a/Fut8/Zfp36l1/Mef2c/Map3k1/Tab1/ Itgb5/Hsp90ab1/Zfp36l2/Bambi/Nrep/Ldlrad4/Smad7/Got1/Acvr2a/Pmepa1/ Skil/Trim33/Sdcbp/Map3k7/Jun/Rasl11b/Sox5/Igf1r/Folr1/Snx25/Hpgd/ Dand5/Skor1/Rnf111/Cd109"" 40" "GO:0010769 ""GO:0010769"" ""regulation of cell morphogenesis involved in differentiation"" ""56/1866"" ""333/23239"" 9.85724339736616e-08 5.61271439046029e-05 4.56027207699203e-05 ""Stau2/Hecw2/Trak2/Bmpr2/ Actr3/Dnm3/Ust/Lims1/Plxnc1/Fstl4/Sipa1l1/Rreb1/Nedd9/Zswim6/Dpysl2/ Slitrk1/Rap2a/Triobp/Kalrn/Sema5b/Robo2/Tiam1/Ttc3/Myo5b/Shtn1/Sema6d/ Adnp/Skil/Sema6c/Ngf/Ppp3ca/Pdlim5/Sh3glb1/Epha7/Ptprd/Sema3c/Ywhah/ Nkx6-1/Coro1c/Ssh1/Ppp1r9a/Plxna1/Arhgap35/Ube3a/Sema4b/Picalm/Nrg1/ Pou4f2/Disc1/Sema7a/Rab11a/Nedd4/Clasp2/Trak1/Xk/Pak3"" 56" "GO:0071559 ""GO:0071559"" ""response to transforming growth factor beta"" ""40/1866"" ""205/23239"" 1.23823907563773e-07 6.40957572425567e-05 5.20771362433285e-05 ""Zfp451/Bmpr2/Actr3/Cited2/ Ptprk/Fyn/Sirt1/Usp15/Mtmr4/Ppm1a/Fut8/Zfp36l1/Mef2c/Map3k1/Tab1/ Itgb5/Hsp90ab1/Zfp36l2/Bambi/Nrep/Ldlrad4/Smad7/Got1/Acvr2a/Pmepa1/ Skil/Trim33/Sdcbp/Map3k7/Jun/Rasl11b/Sox5/Igf1r/Folr1/Snx25/Hpgd/ Dand5/Skor1/Rnf111/Cd109"" 40" "GO:0050808 ""GO:0050808"" ""synapse organization"" ""66/1866"" ""424/23239"" 1.52046254744849e-07 7.21459478764309e-05 5.86178324213694e-05 ""Stau2/Erbb4/Actr3/Dnm3/Utrn/Fyn/Zfp365/Arf1/ Sez6/Nrcam/Arf6/Sipa1l1/Flrt2/Hnrnpk/Mef2c/Htr1a/Slitrk1/Slitrk5/ Ywhaz/Kalrn/App/Tiam1/Synpo/Myo5b/Malat1/Flrt1/Tanc1/Rapgef4/Adnp/ Slc7a11/Pfn2/Pdlim5/Adgrl2/Sdcbp/Epha7/Lingo2/Unc13b/Ptprd/Nfia/Wasf2/ Fzd1/Sept11/Ssh1/Actb/Ppp1r9a/Wasl/Lrrc4/Ctnna2/Dctn1/Vhl/Ube3a/Igf1r/ Picalm/Insr/Col4a1/Nrg1/Rab3a/Adgrl1/Disc1/Mtmr2/Kirrel3/Nectin1/ Nedd4/Ctnnb1/Hdac6/Pak3"" 66" "GO:0031346 ""GO:0031346"" ""positive regulation of cell projection organization"" ""69/1866"" ""454/23239"" 2.02730340431832e-07 8.87958891091424e-05 7.2145736534243e-05 ""Stau2/Bmpr2/Actr3/Cxcr4/ Rgs2/Dnm3/Ahi1/Fyn/Snx3/Sirt1/Plxnc1/Nav3/Grip1/Lif/Ccdc88a/Arf1/Sez6/ Nf1/Itsn2/Prkd1/Rala/Ripor2/Rreb1/Hnrnpk/Enc1/Atp8a2/Slitrk1/Stk24/ Kctd17/Cdc42ep1/Kalrn/Robo2/Tiam1/Kat2b/Myo5b/Cpeb3/Shtn1/Nfe2l2/ Nckap1/Adnp/Skil/Il2/Ngf/Sh3glb1/Ptprd/Wasf2/Fzd1/Scarb2/Coro1c/ Mapkapk5/Hspb1/Ppp1r9a/Wasl/Plxna1/Brk1/Eps8/Arhgap35/Igf1r/Picalm/ Nrg1/Crtc1/Pou4f2/Disc1/Sema7a/Rab11a/Mapk6/Eef1a1/Trak1/Pak3"" 69" "GO:0007178 ""GO:0007178"" ""transmembrane receptor protein serine/ threonine kinase signaling pathway"" ""57/1866"" ""350/23239"" 2.31549625085626e-07 9.41581075096542e-05 7.6502483224249e-05 ""Zfp451/Bmpr2/Inhbb/Grem2/Cited2/Akap7/Ptprk/Sirt1/Fstl3/Usp15/Gdf11/ Mtmr4/Tmem100/Ddx5/Ppm1a/Fut8/Map3k1/Fgf9/Gata4/Tab1/Hes1/Itgb5/Lnpep/ Hsp90ab1/Tgif1/Bambi/Nrep/Egr1/Ldlrad4/Smad7/Rnf165/Dmrt1/Got1/Tcf7l2/ Acvr2a/Pmepa1/Skil/Slc33a1/Ppm1l/Hfe2/Notch2/Trim33/Sdcbp/Map3k7/Jun/ Fzd1/Rasl11b/Folr1/Rbpms/Snx25/Hpgd/Mir23a/Dand5/Bmper/Skor1/Rnf111/ Cd109"" 57" "GO:0001667 ""GO:0001667"" ""ameboidal-type cell migration"" ""63/1866"" ""403/23239"" 2.48045594071797e-07 9.41581075096542e-05 7.6502483224249e-05 ""Map4k4/Bmpr2/Erbb4/Clasp1/Actr3/Cxcr4/Adipor1/ Sirt1/Arid5b/Kitl/Anxa6/Cenpv/Nf1/Hdac9/Prkd1/Arf6/Syne2/Rreb1/Mef2c/ Nr4a1/Sp1/Sema5b/Smoc2/Sox8/Ptprm/Fgf1/Pkn3/Nfe2l2/Nckap1/Spred1/ Sema6d/Pfn2/Sema6c/Pkn2/Klf4/Jun/Cap1/Macf1/Wasf2/Plekhg5/Sema3c/ Paxip1/Coro1c/Ptpn11/P2rx4/Scarb1/Hspb1/Hmgb1/Smo/Adamts9/Vhl/Sema4b/ Gab2/Wnt11/Folr1/Pik3c2a/Pkn1/Bmper/Sema7a/Rab11a/Clasp2/Hdac6/Pak3"" 63" "GO:0009896 ""GO:0009896"" ""positive regulation of catabolic process"" ""62/1866"" ""401/23239"" 4.55545919342675e-07 0.000150226780922851 0.000122057697327922 ""Hecw2/Rufy4/Gigyf2/Atg4b/ Rab3gap1/Cop1/Rc3h1/Epm2a/Rnf217/Gja1/Supv3l1/Sirt1/Sgta/Irgm1/Larp1/ Cnot8/Trib2/Prkd1/Zfp36l1/Lpcat1/Trim13/Rnf19a/Rnf139/Tnrc6b/Prickle1/ Crebrf/Bag6/Zfp36l2/Wac/Ndfip1/Csnk1a1/Smad7/Fam122a/Il33/Cpeb3/ Ambra1/Il1b/Ptpn1/Dhx36/Mov10/Mettl14/Sh3glb1/Map3k7/Trim32/Sesn2/ Fbxl5/Cnot6l/Hnrnpd/Hmgb1/Zc3hav1/Hk2/Nop53/Supt5/Fgf21/Insr/Cnot7/ Wwp2/Disc1/Sorl1/Vps11/Nedd4/Hdac6"" 62" "GO:0003007 ""GO:0003007"" ""heart morphogenesis"" ""47/1866"" ""274/23239"" 5.72543154132114e-07 0.000171582143138329 0.000139408707058761 ""Fhl2/Bmpr2/Mdm4/Cited2/Ahi1/Gja1/Sirt6/Tmem100/ Med1/Rara/Axin2/Flrt2/Ptch1/Mef2c/Zmiz1/Fgf9/Gata4/Mir17/Zfpm2/Tab1/ Mkl2/Hes1/Robo2/Erg/Sos1/Smad7/Kdm2a/Notch2/Rbm15/Jun/Myom3/Fzd1/ Sema3c/Tbx5/Tmed2/Ncor2/Smo/Wnt11/Folr1/Tead1/Insr/Myom2/Dlc1/Cpe/ Yap1/Nedd4/Ctnnb1"" 47" "GO:0048588 ""GO:0048588"" ""developmental cell growth"" ""44/1866"" ""252/23239"" 7.8921635972867e-07 0.000224689897614752 0.000182558205316184 ""Bmpr2/Actr3/Cxcr4/Rgs2/Sirt1/Sirt6/Fstl4/Itsn2/ Akap6/Hnrnpk/Vcl/Gata4/Dpysl2/Sema5b/App/Tiam1/Ddr1/Hsp90ab1/Myo5b/ Flrt1/Shtn1/Sema6d/Cpne1/Adnp/Sema6c/Ngf/Pdlim5/Sh3glb1/Epha7/Sema3c/ Nkx6-1/Smo/Plxna1/Akap13/Sema4b/Picalm/Nrg1/Pou4f2/Disc1/Sema7a/ Rab11a/Clasp2/Ctnnb1/Hdac6"" 44" "GO:0021915 ""GO:0021915"" ""neural tube development"" ""36/1866"" ""190/23239"" 1.08165923182003e-06 0.000293284174570631 0.00023829034204757 ""Traf3ip1/Enah/Cited2/Nf1/Rara/Zfp36l1/Rala/ Ptch1/Fzd3/Scrib/Nup50/Prickle1/Hes1/Ift140/Tgif1/Kdm2a/Pax2/Tcf7l2/ Bmi1/Nckap1/Ambra1/Lmo4/Map3k7/Arid1a/Fzd1/Sema3c/Wdr19/Kdm2b/Tmed2/ Smo/Arhgap35/Folr1/Adm/Dlc1/Prkaca/Nup133"" 36" "GO:0035265 ""GO:0035265"" ""organ growth"" ""38/1866"" ""209/23239"" 1.5865103698161e-06 0.000336192293737761 0.00027315274267973 ""Erbb4/ Rgs2/Kcnk2/Cited2/Map7/Hdac2/Gja1/Psap/Sirt1/Sirt6/Dusp6/Anxa6/Rara/ Akap6/Mef2c/Lats2/Fgf9/Gata4/Prlr/Zfpm2/Rxrb/Fgf1/Tcf7l2/Wt1/Pdlim5/ Col27a1/Acacb/Tbx5/Ptpn11/Smo/Ube3a/Akap13/Tenm4/Yap1/1190002N15Rik/ Poc1a/Ctnnb1/Ar"" 38" "GO:0033044 ""GO:0033044"" ""regulation of chromosome organization"" ""54/1866"" ""346/23239"" 1.84020761685198e-06 0.00037421936322697 0.00030404934120543 ""Zfp451/Hecw2/Xrcc5/Trip12/Hnrnpu/Nek2/Sirt1/ Sirt6/Lif/Pttg1/Srebf1/Cenpv/Ctc1/Aurkb/Smg6/Tex14/Axin2/H3f3b/Wbp2/ Prkd1/Jdp2/Hist1h1c/Rad21/Mtbp/Slx4/Ercc4/Kat2b/Fshr/Kdm2a/Tnks2/Slf2/ Stn1/Rif1/Tlk1/Nat10/Eid1/Zfp335/Dhx36/Setdb1/Cdk5rap2/Paxip1/Hnrnpd/ Mtf2/Sart3/Mapkapk5/Anapc5/Mad1l1/Kdm3a/Lrrk1/Setd1a/Bub3/Mki67/ Ctnnb1/Phf8"" 54" "GO:0017148 ""GO:0017148"" ""negative regulation of translation"" ""28/1866"" ""133/23239"" 1.9631743065219e-06 0.000385459120735714 0.00031318152730177 ""Gigyf2/Rgs2/Rc3h1/Cnot2/Eif4enif1/Larp1/Cnot8/ Rara/Zfp36l1/Enc1/Ang/Rnf139/Tnrc6b/Zfp36l2/Cpeb3/Wt1/Fxr1/Dhx36/ Mov10/Mettl14/Eif4e/Sesn2/Cnot6l/Hnrnpd/Tia1/Samd4b/Rpl13a/Cnot7"" 28" "GO:0048638 ""GO:0048638"" ""regulation of developmental growth""