April 15 – 17, 2016 Fairmont Chicago Millennium Park • Chicago, Illinois The AAP/ASCI/APSA conference is jointly provided by Boston University School of Medicine and AAP/ASCI/APSA. Meeting Program and Abstracts www.jointmeeting.org www.jointmeeting.org Special Events at the 2016 AAP/ASCI/APSA Joint Meeting Friday, April 15 Saturday, April 16 ASCI President’s Reception ASCI Food and Science Evening 6:15 – 7:15 p.m. 6:30 – 9:00 p.m. Gold Room The Mid-America Club, Aon Center ASCI Dinner & New Member AAP Member Banquet Induction Ceremony (Ticketed guests only) (Ticketed guests only) 7:00 – 10:00 p.m. 7:30 – 9:45 p.m. Imperial Ballroom, Level B2 Rouge, Lobby Level How to Solve a Scientific Puzzle: Speaker: Clara D. Bloomfield, MD Clues from Stockholm and Broadway The Ohio State University Comprehensive Cancer Center Speaker: Joe Goldstein, MD APSA Welcome Reception & University of Texas Southwestern Medical Center at Dallas Presidential Address APSA Dinner (Ticketed guests only) 9:00 p.m. – Midnight Signature Room, 360 Chicago, 7:30 – 9:00 p.m. John Hancock Center (off-site) Rouge, Lobby Level Speaker: Daniel DelloStritto, APSA President Finding One’s Scientific Niche: Musings from a Clinical Neuroscientist Speaker: Helen Mayberg, MD, Emory University Dessert Reception (open to all attendees) 10:00 p.m. – Midnight Imperial Foyer, Level B2 Sunday, April 17 APSA Future of Medicine and www.jointmeeting.org Residency Luncheon Noon – 2:00 p.m. Rouge, Lobby Level 2 www.jointmeeting.org Program Contents General Program Information 4 Continuing Medical Education Information 5 Faculty and Speaker Disclosures 7 Scientific Program Schedule 9 Speaker Biographies 16 Call for Nominations: 2017 Harrington Prize for Innovation in Medicine 26 AAP/ASCI/APSA Joint Meeting Faculty 27 Award Recipients 29 Call for Nominations: 2017 Harrington Scholar-Innovator Award 31 Call for Nominations: George M. Kober Lecture and Medal 32 Abstracts: APSA Trainee Oral Presentations 34 Abstracts: AAP/ASCI/APSA Posters 35 Abstracts: Young Physician-Scientist Award (YPSA) Posters 116 Abstracts: Howard Hughes Medical Institute Medical Fellows Posters 137 Poster Author Index 176 Hotel Floor Plans 192 APSA Funders List Inside Back Cover AAP/ASCI Supporters Back Cover 3 www.jointmeeting.org General Information Registration Desk Hours Poster Session Schedule Friday, April 15 7:00 a.m. – 6:30 p.m. Friday, April 15 Saturday, April 16 7:00 a.m. – 5:00 p.m. 1:00 p.m. – 3:00 p.m. Poster Setup Sunday, April 17 7:30 a.m. – 10:00 a.m. 6:15 p.m.– 9:30 p.m. Informal Viewing: presenters do not need to be Americans with Disabilities Act at poster Event staff will be glad to assist you with any special needs (i.e., physical, dietary, etc.). Please contact the Registration Desk at Saturday, April 16 the meeting if you require any special assistance. TWO Poster Presentation Sessions 8:00 a.m. – 9:30 a.m. Poster Session with Joint Meeting Evaluations Continental Breakfast ODD numbered posters presented The AAP/ASCI/APSA Joint Meeting Planning Committee relies on your input to enhance its meetings. Following the Joint Featuring presentations by the Meeting, an online meeting evaluation will be emailed to all ASCI’s 2016 Young Physician-Scientist attendees. APSA attendees will receive a separate survey to Awardees help its planning committee enhance APSA-sponsored events at future AAP/ASCI/APSA Joint Meetings. Your participation in this 11:45 a.m. – 1:30 p.m. Poster Session with Lunch survey is greatly appreciated. EVEN numbered posters presented 1:30 p.m. – 2:00 p.m. Poster Dismantle AAP/ASCI/APSA Joint Meeting Code of Conduct 2:45 p.m. – 3:00 p.m. Outstanding Poster Awards We value your attendance. Our conference is dedicated (during Plenary III in International to providing a harassment-free experience for everyone, Ballroom) regardless of gender, gender identity and expression, age, Poster abstract submitters should plan to be available on sexual orientation, disability, physical appearance, body size, Saturday for their appointed poster presentation session and the race, ethnicity, or religious preference. AAP/ASCI/APSA do not resulting awards program later in the afternoon. tolerate harassment of conference participants in any form. A participant engaging in harassing behavior will be warned and may be asked to leave the conference with no refund. If you are Outstanding Poster Awards being harassed, notice that someone else is being harassed, or have any other concerns, please contact a member of Best Poster Awards will be given in the amount of $1,000 each. conference staff at the registration desk immediately. Conference Members of the AAP, ASCI and APSA will judge posters on staff and organizers are dedicated to making all participants feel scientific novelty, quality and clarity of presentation. Awards will safe for the duration of the conference. be presented on Saturday, April 16, from 2:45 – 3:00 p.m. 4 www.jointmeeting.org Continuing Medical Education Information Overview Course Director The Joint Meeting Planning Committee strives to represent Edward Alexander, MD the cutting edge of biomedical research and medicine. The Boston University School of Medicine Committee is especially interested in identifying gaps in knowledge that may exist in the target audience, which consists Program Planning Committee of physician-scientists, research scientists, clinicians and medical Christine E. Seidman, MD education professionals. The meeting also targets junior AAP President scientists and trainees, who benefit from close interaction with Brigham and Women’s Hospital senior colleagues. Linda Fried, MD The 2016 AAP/ASCI/APSA Joint Meeting program will feature AAP Vice President lectures by accomplished researchers who will discuss state- Columbia University, Mailman School of Public Health of-the-art advances in their respective fields. The program is designed to foster in-depth discussions and close interactions Paul Rothman, MD among the meeting participants. AAP Immediate Past President Johns Hopkins University Claiming CME Credit Dan DelloStritto Participants will receive a CME Personal Attendance Log (6th year MD/PhD) with conference materials. The log includes instructions for Northeast Ohio Medical University completing the online CME application and evaluation. In order Jillian Liu to receive credits this online evaluation must be completed. (4th Year MD/PhD) CME Certificates will be sent within 8 weeks of completing the The Ohio State University application. Feel free to contact LaTanya Morris at lmorris@ jointmeeting.org with any questions. Levi Garraway, MD, PhD ASCI President Accreditation and Credit Designation Harvard Medical School, Dana-Farber Cancer Institute Vivian Cheung, MD This activity has been planned and implemented in accordance ASCI President-Elect with the accreditation requirements and policies of the Howard Hughes Medical Institute, University of Michigan Accreditation Council for Continuing Medical Education through the joint providership of Boston University School of Medicine, Mukesh K. Jain, MD the American Society for Clinical Investigation, the Association ASCI Immediate Past President of American Physicians and the American Physician Scientists Case Western Reserve University School of Medicine Association. Lori Ennis Boston University School of Medicine designates this live activity Executive Director AAP, Ex Officio Committee Member for a maximum of 8.5 AMA PRA Category 1 Credits™. Physicians John Hawley should claim only the credit commensurate with the extent of Executive Director ASCI, Ex Officio Committee Member their participation in the activity. Nurses and other health professionals will receive a Certificate of Attendance. For information on applicability and acceptance, please consult your professional licensing board. 5 www.jointmeeting.org Continuing Medical Education Information Learning Objectives The 2016 AAP/ASCI/APSA Joint Meeting program is organized into several plenary sessions that have broad applicability: As a result of this meeting, participants will be able to: “Good and Bad Bugs” (focused on infectious disease and • Describe important recent advances in the scientific basis of immunology), “Epigenetics and Transcriptional Regulation of disease and therapy Human Disease” (external influences on gene switching), “Cool Tools and Forward Technology” (tissue engineering and drug • Describe novel strategies to address challenges to the discovery), and “Metabolism” (regulation of the endocrine physician-scientist system and drug development). • Describe the roles that improved understanding of these DISCLAIMER: THESE MATERIALS AND ALL OTHER MATERIALS advances and strategies can play in the potential treatment PROVIDED IN CONJUNCTION WITH CONTINUING MEDICAL of human disease EDUCATION ACTIVITIES ARE INTENDED SOLELY FOR PURPOSES OF SUPPLEMENTING CONTINUING MEDICAL Target Audience EDUCATION PROGRAMS FOR QUALIFIED HEALTH CARE Any physician-scientists, trainees, and students, across a PROFESSIONALS. ANYONE USING THE MATERIALS broad range of specialties (Basic Research, Cardiology / ASSUMES FULL RESPONSIBILITY AND ALL RISK FOR THEIR Cardiovascular Research, Cell And Molecular Biology, Endocrine APPROPRIATE USE. TRUSTEES OF BOSTON UNIVERSITY and Metabolism, Hematology, Immunology, Infectious Diseases, MAKES NO WARRANTIES OR REPRESENTATIONS Nephrology, Neurology, Pulmonology, others.) WHATSOEVER REGARDING THE ACCURACY, COMPLETENESS, CURRENTNESS, NONINFRINGEMENT, MERCHANTABILITY OR Educational Need FITNESS FOR A PARTICULAR PURPOSE