Curriculum Vitae PERSONAL INFORMATION Leon Aarons WORK EXPERIENCE March 1976- Present Professor The University of Manchester (United Kingdom) Researcher and teacher in the areas of pharmacokinetics and pharmacodynamics EDUCATION AND TRAINING September 1971-December 1973 PhD The University of Manchester (United Kingdom) PhD in Theoretical Chemistry ADDITIONAL INFORMATION Expertise Pharmacokinetic and pharmacodynamic modelling; population pharmacokinetic modellingt; optimal design of pharmacokinetic and pharmacodynamic clinical trials; physiologically based pharmacokinetic modelling; drug absorption modelling Publications S.Y.A. Cheung, T. Rodgers, L. Aarons, I. Gueorguieva, G.L. Dickinson, S. Murby, C. Brown, B. Collins, M. Rowland, Whole body physiologically based modelling of -blockers in the rat: events in tissues and plasma following an i.v. bolus dose, Br J Pharmacol DOI:10.1111/bph.14071 (2017). Y.T. Patel, V.M. Daryani, P. Patel, D. Zhou, J. Fangusaro, D.J. Carlile, P.D. Martin, L Aarons, C.F. Stewart, 'Population pharmacokinetics of selumetinib and its metabolite N-desmethyl-selumetinib in adult patients with advanced solid tumors and children with low-grade gliomas CPT Pharmacometrics Syst Pharmacol 6, 305-314 (2017). S.C. Goulooze, S. Völler, P.A.J. Völitalo, E.A.M. Calvier, L. Aarons, E.H.J. Krekels, C.A.J. Knibbe, The influence of normalization weight in population pharmacokinetic covariate models, Clin Pharmacokinet DOI:10.1007/s40262-018-0652-7 (2018). C. Imholt,| T. Abdulla,| A. Stevens,| P. Edwards,| J. Jacob, D. Woods, E. Rogers, L. Aarons, D. Segelcke, Establishment and validation of microsampling techniques in wild rodents for ecotoxicological research, Appl Toxicol DOI: 10.1002/jat.3635 (2018). E.C. Martin, L. Aarons, J.W.T. Yates, Pharmacodynamic modelling of resistance to epidermal growth factor receptor inhibition in brain metastasis mouse models, Cancer Chemother Pharmacol DOI:10.1007/s00280-018-3630-8 (2018). C. Imholt, T. Abdulla, A. Stevens, P. Edwards, J. Jacob, D. Woods, E. Rogers, L. Aarons, D. Segelcke, Establishment and validation of microsampling techniques in wild rodents for ecotoxicological research J Appl Toxicol DOI:10.1002/jat.3635 (2018). R. Vashisht, A.A. Bendon, I. Okonkwo, D. Patel, C. Fullwood, K. Ogungbenro, L. Aarons, A.S. Darwich, A Study of the dosage and duration for levobupivacaine infusion by the caudal-epidural route in infants aged 3-6 months, Pediatric Anesthesia 29, 161-168 DOI:10.1111/pan.13548 (2019). N. Melillo, L. Aarons, P. Magni, A.S. Darwich, Variance based global sensitivity analysis of physiologically based pharmacokinetic absorption models for BCS IIV drugs, J Pharmacokin Pharmacodyn 46, 27-42 DOI:10.1007/s10928-018-9615-8 (2019). E. Yau, A. Olivares-Morales, M. Gertz, N. Parrott, A.S. Darwich, L. Aarons, K. Ogungbenro, Global Sensitivity Analysis of the Rodgers and Rowland Model for Prediction of Tissue: Plasma Partitioning Coefficients: Assessment of the Key Physiological and Physicochemical Factors That Determine Small-Molecule Tissue Distribution, The AAPS Journal 22, DOI: 10.1208/s12248-020-0418-7 (2020). 16/12/2020 European Medicine Agency Page 1/2 A. Lombard, H. Mistry, S.C. Chapman, I. Gueoguieva, L. Aarons, K. Ogungbenro, Impact of tumour size measurement interoperator variability on modelbased drug effect evaluation, Cancer Chemother Pharmacol DOI.org/10.1007/s00280-020-04049-5 (2020). E. M. del Amo, J.R. Griffiths, I. P. Klaska, J. Hoke, A. White, L.Aarons, G. J. S. Cooper, J. W. B. Bainbridge, P. N. Bishop, R. D. Unwin, Intravitreal pharmacokinetic study of the anti-angiogenic glycoprotein opticin, Mol. Pharmaceutics DOI: 10.1021/acs.molpharmaceut.0c00151 (2020). A. Ahmad, X. Pepin, L. Aarons, Y. Wang, A.S. Darwich, et al., IMI Oral biopharmaceutics tools project Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies, Eur J Pharmaceut Sci DOI: 10.1016/j.ejpb.2020.08.006. A. Lombard, H. Mistry, L. Aarons, K. Ogungbenro, Dose individualisation in oncology using chemotherapyinduced neutropenia: example of docetaxel in nonsmall cell lung cancer patients, Br J Clin Pharmacol DOI 10.1111/bcp.14614 (2020). Projects 2012-2018IMI (Framework 7), Orbito: Oral biopharmaceutical tools 2011-2014MRC, Rare disease: use of clinical trial simulation for the choice and optimization of study design (CRESim) 2005-2009Framework 6 Network of Excellence, Biosimulation - A New Tool inDrug Development. Memberships Member of United Kingdom Quantitative Systems Pharmacology group Editor Emeritus, Journal of Pharmacvokinetics and Pharmacodynamics Editorial board: Journal of Pharmacy and Pharmacology; European Journal of Pharmaceutical Sciences, Pharmacology Research & Perspectives Other Relevant Information 16/12/2020 European Medicine Agency Page 2/2.