Rabbit Anti-Human HK2 Polyclonal Antibody (CABT-L2270) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Product Overview Polyclonal Antibody to Hexokinase 2 (Knockout Validated) Specificity The antibody is a rabbit polyclonal antibody raised against HK2. It has been selected for its ability to recognize HK2 in immunohistochemical staining and western blotting. Target HK2 Immunogen Recombinant fragment corresponding to human HK2 (Ala469~Asp669) Isotype IgG Source/Host Rabbit Species Reactivity Human Purification Antigen-specific affinity chromatography followed by Protein A affinity chromatography Conjugate Unconjugated Applications WB Format Liquid Concentration Lot specific Size 200 μg Buffer Supplied as solution form in 0.01M PBS with 50% glycerol, pH7.4. Preservative 0.05% Proclin-300 Storage Avoid repeated freeze/thaw cycles. Store at 4°C for frequent use. Aliquot and store at -20°C for 12 months. Ship 4°C with ice bags Warnings For research use only. BACKGROUND 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Introduction Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009] Keywords HK II;Muscle form hexokinase GENE INFORMATION Gene Name HK2 hexokinase 2 [ Homo sapiens (human) ] Official Symbol HK2 Synonyms HK2; hexokinase 2; HKII; HXK2; hexokinase-2; HK II; hexokinase type II; hexokinase-2, muscle; muscle form hexokinase; Entrez Gene ID 3099 Protein Refseq NP_000180 UniProt ID P52789 Chromosome Location 2p13 Pathway Amino sugar and nucleotide sugar metabolism; Butirosin and neomycin biosynthesis; Carbohydrate digestion and absorption; Carbon metabolism; Central carbon metabolism in cancer; Disease; Fructose and mannose metabolism; Galactose metabolism; Function ATP binding; fructokinase activity; glucokinase activity; glucose binding; hexokinase activity; mannokinase activity; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.