Anti-SRPK1 (aa 275-325) polyclonal antibody (DPABH-11733) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description Plays a central role in the regulatory network for splicing, controlling the intranuclear distribution of splicing factors in interphase cells and the reorganization of nuclear speckles during mitosis. Hyperphosphorylates RS domain-containing proteins such as SFRS1, SFRS2 and ZRSR2 on serine residues during metaphase but at lower levels during interphase. Locks onto SFRS1 to form a stable complex and processively phosphorylates the RS domain. Appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids. Immunogen Synthetic peptide corresponding to a region within amino acids 275-325 of Human SRPK1 (NP_003128.3). Isotype IgG Source/Host Rabbit Species Reactivity Mouse, Human Purification Immunogen affinity purified Conjugate Unconjugated Applications IHC-P Format Liquid Size 100 μl Buffer Constituents: 99% Tris buffered saline, 0.1% BSA Preservative 0.09% Sodium Azide Storage Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. GENE INFORMATION Gene Name SRPK1 SRSF protein kinase 1 [ Homo sapiens ] 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Official Symbol SRPK1 Synonyms SRPK1; SRSF protein kinase 1; SFRS protein kinase 1; serine/arginine rich splicing factor kinase 1; SFRSK1; SR protein kinase 1; SR-protein-specific kinase 1; serine/threonine-protein kinase SRPK1; serine/arginine-rich splicing factor kinase 1; Entrez Gene ID 6732 Protein Refseq NP_003128 UniProt ID Q96SB4 Chromosome Location 6p21.31 Pathway Herpes simplex infection; mRNA processing; Function ATP binding; magnesium ion binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.