LANGEBIO, Irapuato, Guanajuato, Mexico Program and Abstracts Organizing committee Andrés Moreno Estrada (LANGEBIO-IPN) Karla Sandoval Mendoza (LANGEBIO-IPN) Mitzi Flores Ponce (LANGEBIO-IPN) María C. Ávila Arcos (LIIGH-UNAM) Victor Acuña Alonzo (ENAH-INAH) #mexpopgen3 Program 9:30-10:00 Registration 10:00 – 11:35 Session I 10:00 – 10:05 – Opening remarks Andrés Moreno-Estrada, LANGEBIO, México 10:05 – 10:35 “Genome Odyssey: Theatre as an effective way to teach scientific concepts to children” Guest Speaker: Anna-Sapfo Malaspinas, University of Lausanne, Switzerland 10:35 -10:55 “Genomics of Middle Neolithic farmers at the fringe of of Europe“ Federico Sánchez-Quinto, Uppsala University, Sweden 10:55-11:15 “Terminal Pleistocene Alaskan genome reveals first founding population of Native Americans” J. Víctor Moreno-Mayar, Natural History Museum of Denmark, University of Copenhagen 11:15 – 11:35“Reconstructing Human Migrations from Genomic data across Latin America and the Pacific“ Andrés Moreno Estrada, LANGEBIO, Mexico 11:35 – 12:00 Coffee break 12:00 – 13:40 Session II 12:00 – 12:30 “Insights into human adaptation” Guest speaker: Emilia Huerta- Sanchez, University of California Merced, USA 12:30 – 12:50 “Imputation of Ancient Hominin ABO Haplotype Structure From Modern Populations” Keolu Fox. University of California, San Diego, USA 12:50 – 13:20 “Tracing the origins 19th century enslaved Africans” Guest speaker: Marcela Sandoval-Velasco, Natural History Museum of Denmark, University of Copenhagen. 13:20 – 13:40 "Phosphatidylcholine balance as a possible driver of maize adaptation to Mexican highlands" Rubén Rellán Álvarez, LANGEBIO, Mexico 13:40 – 15:00 Lunch 15:00 – 16:00 Session III Spark talks by Students - TBD 15:00 – 15:10 “Paleogenomic study of Serranos - a Pre-Hispanic Civilization from Sierra Gorda, Mexico.” Viridiana Villa-Islas, LIIGH-UNAM, Mexico 15:10 – 15:20 “Interspecies Bacterial Competitive Outcomes in C. elegans Intestine Reveal the Principles of Community Assembly in a Simple Animal Gut” Anthony Ortiz MIT, USA 15:20 – 15:30 “Genome-wide allele-specific expression of the transcriptional landscape associated to Capsicum domestication” Erik Omar díaz Valenzela, LANGEBIO-CINVESTAV, Mexico 15:30 – 15:40 "Change in the population structure of maize landraces associated to the introgression from inbreed lines " Idalia Rojas, Instituto de Ecología, UNAM, Mexico 15:40 – 15:50 "Domestication of the open-pollinated scarlet runner bean (Phaseolus coccineus L.)" Azalea Guerra García, Instituto de Ecología, UNAM, Mexico 15:50 – 16:00 "Análisis de asociación de fenotipos de pigmentación en población mexicana del Proyecto CANDELA-México." Paola Everardo Martínez, Instituto de Investigaciones Antropológicas, UNAM Mexico. 16:00 – 17:30 Poster Session Poster presentations 1. “Efecto de las variantes alélicas CYP2C9*2 y CYP2C9*3 en la respuesta terapéutica y farmacocinética de la glibenclamida en población Maya de Yucatán” Barbara I. de la Peña Espinoza et al. 2. “Genomic Insights into the Origin and Diversification of Late Maritime Hunter- Gatherers from the Chilean Patagonia” Constanza de la Fuente et al. 3. “Genetic structure of blue-eyed shags in the Kerguelen and Crozet archipelagos” Juan C. Guevara López et al. 4. “Reconstructing admixture and migration dynamics of Post-Columbian Mexico” Juan E. Rodríguez Rodríguez et al. 5. “Genetic diversity of Afro-descendant communities from the Lesser Antilles.” María A. Nieves et al. 6. Late and gradual domestication of ancient Tehuacan maize Miguel Vallebueno-Estrada et al. 7. “Paleogenomic study of ancient pathogens in Pre-Hispanic indigenous individuals from Central Mexico” Miriam Bravo López et al. 8. Population and evolutionary genomics in non-model mammals Sergio Nigenda-Morales et al. ABSTRACTS Oral presentations 1. Presenter: Anna-Sapfo Malaspinas University of Lausanne, Switzerland [email protected] Title: Genome Odyssey: theatre as an effective way to teach scientific concepts to children Authors and affiliations: Anna-Sapfo Malaspinas, University of Lausanne, Switzerland. Over the course of about eight months a team of roughly 30 professionals in the arts and science worked together to create a theatre play intended for children. The starting point of the play was a scientific publication about the peopling of Australia and the intention was to communicate some scientific results to children as young as 8 years old. The play covered population genetic concepts, was meant to raise awareness about Aboriginal Australians while also conveying the fact that science is fun and is meant for all. We surveyed about 450 children (incl. 200 that took part in a study) before and after the play asking them the same questions to assess how much they learned from it. We present the results in this talk. 2. Presenter: Federico Sánchez-Quinto Uppsala University [email protected] Title: Genomics of Middle Neolithic farmers at the fringe of of Europe Authors and affiliations: Federico Sanchez-Quinto1, Helena Malmström1, Magdalena Fraser1,3, Linus Girdland Flink4, Emma M. Svensson1, Jan Storå5, Anders Götherström2 and Mattias Jakobsson1 1 Department of Organismal Biology, Uppsala University, Norbyvägen 18C, 75236, Uppsala, Sweden 2 Department of Archaeology and Classical Studies, Stockholm University, Wallenberglaboratoriet, 10691 Stockholm, Sweden 3 Department of Archaeology and Ancient History, Uppsala University-Campus Gotland, SE-621 67 Visby, Sweden 4 Research Centre in Evolutionary Anthropology and Palaeoecology, School of Natural Sciences and Psychology, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF. 5 Osteoarchaeological Research Laboratory, Department of Archaeology and Classical Studies, Stockholm University, SE-106 91 Stockholm Agriculture emerged in the Fertile Crescent around 11,000 years before present (BP) and then spread, reaching central Europe some 7,500 years ago (ya.) and eventually Scandinavia by 6,000 years ya. Recent paleogenomic studies have shown that the spread of agriculture from the Fertile Crescent into Europe was due mainly to a demic process. Such event reshaped the genetic makeup of European populations since incoming farmers displaced and admixed with local hunter-gatherers. The Middle Neolithic period in Europe is precisely characterized by such interaction, and a time where a resurgence of hunter- gatherer ancestry has been documented. While most research has been focused on the genetic origin and admixture dynamics with hunter-gatherers of farmers from Central Europe, the Iberian Peninsula, and Anatolia, data from farmers at the North-Western edges Europe remains scarce. Here, we investigate genetic data from Middle Neolithic from Ireland, Scotland, and Scandinavia and compare it to genomic data from hunter-gatherers, Early and Middle Neolithic farmers across Europe. We note affinities between the British Isles and Iberia, confirming previous reports. Moreover, we note some indications of interactions between Middle Neolithic Farmers of the British Isles and Scandinavia. Finally, our data together that of previous publications allow us to grasp a better understanding of the interactions between farmers and hunter-gatherers at the northwestern fringe of Europe. 3. Presenter: J. Víctor Moreno-Mayar Natural History Museum of Denmark, University of Copenhagen [email protected] Title: Terminal Pleistocene Alaskan genome reveals first founding population of Native Americans Authors and affiliations: J. Víctor Moreno-Mayar (1) Ben A. Potter (2) Lasse Vinner (1) Matthias Steinrücken (3,4) Simon Rasmussen (5) Jonathan Terhorst (6,7) John A. Kamm (6,8) Anders Albrechtsen (9) Anna-Sapfo Malaspinas (1,10,11) Martin Sikora (1) Joshua D. Reuther (2) Joel D. Irish (12) Ripan S. Malhi (13,14) Ludovic Orlando (1) Yun S. Song (6,15,16) Rasmus Nielsen (1,6,17) David J. Meltzer (1,18) Eske Willerslev (1,8,19) (1) Centre for GeoGenetics, Natural History Museum of Denmark, University of Copenhagen (2) Department of Anthropology, University of Alaska (3) Department of Biostatistics and Epidemiology, University of Massachusetts (4) Department of Ecology and Evolution, University of Chicago (5) Center for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark (6)Department of Statistics, University of California, Berkeley (7)Department of Statistics, University of Michigan (8) Wellcome Trust Sanger Institute, Wellcome Genome Campus. (9) The Bioinformatics Centre, Department of Biology, University of Copenhagen (10) Department of Computational Biology, University of Lausanne (11) Swiss Institute of Bioinformatics (12) Research Centre in Evolutionary Anthropology and Palaeoecology, Liverpool John Moores University (13) Department of Anthropology, University of Illinois at Urbana-Champaign (14) Carle R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign. (15) Computer Science Division, University of California, Berkeley (16) Chan Zuckerberg Biohub, San Francisco, California (17) Department of Integrative Biology, University of California (18) Department of Anthropology, Southern Methodist University. (19) Department of Zoology, University of Cambridge. Recent studies of contemporary Native Americans have revealed a high degree of genetic structure, some of which is inferred to date back to the late Pleistocene arrival of the first Americans. However, evidence from archaeology, skeletal anatomy, linguistics and modern genetics has not resolved whether this early structure