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Seffernicket al. (2001) J Bacteriol 183:2405-2410.* (60) Provisional application No. 60/207,456, filed on May 26, 2000, provisional application No. 60/234,687, filed on Sep. Lloyd, D., “Human DNA Sequence from Clone 21, 2000, provisional application No. 60/236,359, filed on CTA-125H2 on Chromosome 22d 11-12 Contains Part of Sep. 27, 2000, and provisional application No. 60/266,860, the Gene for a Novel Protein Similar to KIAA0216 and filed on Feb. 5, 2001. Myosin Heavy Chain, ESTs, GSSs, and a CpG Island,” (30) Foreign Application Priority Data Database EMBL (Online), Entry HS125H2, Accession No. Z98949 (Sep. 6, 1997). Oct. 4, 2000 (GB) ............................................. OO24263 (List continued on next page.) (51) Int. Cl." .......................... C12N 9/16; C12N 15/00; C12N 5/00; CO7H 21/04 Primary Examiner Rebecca A. Prouty (52) U.S. Cl. ................. 435/196; 435/320.1; 435/287.2; ASSistant Examiner David J Steadman 435/325; 435/419, 435/252.3; 435/254.11; (74) Attorney, Agent, or Firm-Fish & Neave; Daniel M. 536/23.2; 536/23.5 Becker; David A. Roise (58) Field of Search ............................... 536/23.1, 23.2, 536/23.5, 24.31; 435/320.1, 196, 254.11, (57) ABSTRACT 325, 252.3, 287.2, 419, 514/44 Presented are a novel myosin-like protein particularly expressed in human heart and muscle, isolated nucleic acids (56) References Cited encoding the myosin-like protein, compounds and compo U.S. PATENT DOCUMENTS Sitions derivable directly or indirectly therefrom, and diag 3.687,808 A 8/1972 Merigan, Jr. et al. nostic and therapeutic methods for using the Same. 3,980.986 A 9/1976 Baird et al. 4,246.774 A 1/1981 Flesselles et al. 50 Claims, 19 Drawing Sheets US 6,686,188 B2 Page 2 U.S. PATENT DOCUMENTS 5,789,650 A 8/1998 Lonberg et al. 5,795,972 A 8/1998 Kmiec 29: A 3. 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