COVID-19, AI and the Future of Medicine Front Line Innovations and Insights MAY 11, 2020 VIRTUAL GATHERING worldmedicalinnovation.org 2 3 CONTENTS 7 Welcome 11 Steering Committee 13 Sponsors 14 Imagining Health Care in 2030 15 Lynn Bry, MD, PhD 15 Alistair Erskine, MD 16 Keith Flaherty, MD 17 Daphne Haas-Kogan, MD 17 Jayashree Kalpathy-Cramer, PhD 18 Elizabeth Karlson, MD 19 Bharti Khurana, MD 19 Adam Landman, MD 20 Thomas McCoy, MD 20 Patricia Musolino, MD, PhD 21 Rochelle Walensky, MD 21 Bradley Welling, MD, PhD 22 Mass General Brigham Innovation 24 Agenda 30 Innovation Growth Board 32 Commercialization Council 41 Planning Committee 43 2021 World Medical Innovation Forum + worldmedicalinnovation.org Partners HealthCare is now Mass General Brigham WEB BLOG worldmedicalinnovation.org innovationblog.partners.org LINKEDIN TWITTER Partners HealthCare Innovation @PHSInnovation YOUTUBE HASHTAG World Medical Innovation Forum #WMIF2020 SPEAKER AFFILIATIONS BH | Brigham and Women's Hospital; MGH | Massachusetts General Hospital; HMS | Harvard Medical School; MEE | Mass. Eye and Ear; NWH | Newton-Wellesley Hospital TogetherTogether we are strong. Bayer is contributing to the global fight against the coronavirus through our products and expertise in health and nutrition. bayer.com/corona DRUCK_BAG_Anz_CoronaStrong_17x11Zoll_cmyk_mh04.indd Alle Seiten 27.04.20 09:53 Together we are strong. Bayer is contributing to the global fight against the coronavirus through our products and expertise in health and nutrition. bayer.com/corona DRUCK_BAG_Anz_CoronaStrong_17x11Zoll_cmyk_mh04.indd Alle Seiten 27.04.20 09:53 6 7 WELCOME This year we gather for the sixth annual World Medical Thank you for joining us. This year’s event will feature in- Innovation Forum in the extraordinary environment of depth engagement among expert panelists. Our enduring a world-wide pandemic that has altered medicine, the goal remains to provide an environment where principals delivery of care to patients, and the way we live. This virtual can directly share their insights and priorities. While the meeting will explore the technologies driving the response Forum’s speakers have been managing their organizations' to the coronavirus, how medicine is being reinvented real COVID-19 response they have also been reflecting on how time and how the urgency of today will take root in the care will be improved by the tools, insights and resolve future. In 18 virtually broadcast sessions, Mass General gained in fighting this pandemic. Brigham’s Harvard faculty, industry experts and leading The Forum is brought to you by Innovation, the global investors will jointly reflect on the technologies and business development arm of Mass General Brigham. Its challenges defining this historic era in health care. mission is the commercial application of the breakthroughs The World Medical Innovation Forum was established and unique capabilities of the system’s 6200 Harvard faculty to reaffirm the importance of collaborative innovation— —bringing benefits to patients worldwide and generating academia, industry and government working together to new resources to further the nation's largest academic create solutions to medicine’s great challenges. Our goal is research enterprise. Our work continues as we help to to provide actionable insights for Forum participants. We collaboratively shape fundamentally transformed care. are grateful to the 60 senior executives, investors, Harvard We express our deep appreciation to the many individuals clinicians and investigators who will share their insights as who made this Forum possible and are particularly grateful speakers. to our speakers for sharing their passion, expertise We welcome thousands of audience participants from and unique perspectives. Generous support by our dozens of countries and nearly every state. I thank our leading sponsors – Bayer, GE Healthcare, Biogen, Boston many sponsors representing some of the most innovative Scientific, Fujifilm, InterSystems, One Medical and Siemens companies in health care and the Steering Committee Healthineers – underpins today’s event. and Planning Team for their outstanding contributions. I Many thanks to the Steering Committee members whose recognize our Co-chairs Gregg Meyer, MD, Chief Clinical insights made the Forum possible and the Planning Team’s Officer, and Ravi Thadhani, MD, Chief Academic Officer, as dedicated work. well as Chris Coburn, Chief Innovation Officer, for their leadership. We hope that many of you will join us next year Enjoy the day and we look forward to seeing you in person in-person on May 10-12, 2021 when we reconvene. May 10-12, 2021 in Boston! Anne Klibanski, MD Gregg Meyer, MD President and CEO, Mass General Brigham; Chief Clinical Officer, Mass General Brigham; Laurie Carrol Guthart Professor of Medicine, Interim President, NWH; Professor of Medicine, HMS HMS (World Forum Co-Chair) Ravi Thadhani, MD Chief Academic Officer, Mass General Brigham; In addition to our dialogue today, we want Professor, HMS (World Forum Co-Chair) to share forecasts made by a number of our leading Harvard faculty on technologies that will characterize medicine in 2030. Christopher Coburn Please see page 15. Chief Innovation Officer, Mass General Brigham As these past weeks and months prove, THE FUTURE OF MEDICINE THANK YOU has – and always will be – people. Thank you to the hospital staffs, doctors, nurses, first responders and the entire healthcare community for showing the world how to bravely elevate patient care. gehealthcare.com As these past weeks and months prove, THE FUTURE OF MEDICINE THANK YOU has – and always will be – people. Thank you to the hospital staffs, doctors, nurses, first responders and the entire healthcare community for showing the world how to bravely elevate patient care. gehealthcare.com 10 11 Many thanks to the members of STEERING the Steering Committee for their leadership in shaping the Forum agenda, identifying speakers and COMMITTEE securing sponsors. Gregg Meyer, MD Ravi Thadhani, MD Chief Clinical Offi cer, Mass General Chief Academic Offi cer, Mass General Brigham; Interim President, NWH; Brigham; Professor, HMS (World Forum Professor of Medicine, HMS (World Co-Chair) Forum Co-Chair) Katherine Andriole, PhD Jeffrey Golden, MD John Miller, MD Director of Research Strategy Chair, Department of Pathology, Director, Retinal Imaging, and Operations, MGH & BH BH; Ramzi S. Cotran Professor of MEE; Assistant Professor, CCDS; Associate Professor, Pathology, HMS Ophthalmology, HMS Radiology, HMS Adele Gulfo Shawn Murphy, Samuel Aronson Chief of Commercial MD, PhD Executive Director, IT, Development, Roivant Sciences Chief Research Information Personalized Medicine, Mass Offi cer, Mass General Brigham; General Brigham Daphne Professor of Neurology, HMS Haas-Kogan, MD Dave Barrett Chair, Department of Radiation James Noga Managing Partner, VP and Chief Information Offi cer, Polaris Partners Oncology, BH; Professor of Radiation Oncology, HMS Mass General Brigham Giles Boland, MD Adam Koppel, MD, PhD Sunil Puria, PhD Chair, Department of Radiology, Managing Director, Bain Capital Associate Director of Eaton- BH; Philip H. Cook Professor of Life Sciences Fund Peabody Laboratories, Radiology, HMS MEE; Associate Professor of Otolaryngology-Head and Neck James Brink, MD Adam Landman, MD Surgery, HMS Radiologist-in-Chief, MGH; VP, Chief Information and Digital Innovation Offi cer, BH; Associate Juan M. Taveras Professor of Chandra Radiology, HMS Professor of Emergency Medicine, HMS Ramanathan, PhD Global Head, Pharma R&D Open Keith Dreyer, DO, PhD Innovation, Bayer Chief Data Science Offi cer, Mass David Louis, MD Pathologist-in-Chief, MGH; General Brigham; Vice Chairman, Sue Siegel Radiology, MGH; Associate Benjamin Castleman Board Member, Illumina, the Professor, Radiology, HMS Professor of Pathology, HMS Kaiser Family Foundation, and Align Technologies Alistair Erskine, MD Barbara Lubash Principal, Atlantic Chief Digital Health Offi cer, Mass Krishna Yeshwant, MD General Brigham Pacifi c Advisors Partner, Google Ventures; Instructor in Medicine, BH Jean-François Calum MacRae, MD, PhD Vice Chair, Scientifi c Innovation, Formela, MD CEO, One Brave Idea, BH; Partner, Atlas Venture Associate Professor of Medicine, HMS AFFILIATIONS BH | Brigham and Women's Hospital; MGH | Massachusetts General Hospital; HMS | Harvard Medical School; MEE | Mass. Eye and Ear 12 13 SPONSORS The 2020 Virtual World Medical Innovation Forum was made possible through the sponsorship of some of health care’s most important companies. STAKEHOLDER Bayer Leverkusen, Germany Bayer is a global enterprise with core competencies in the Life Science fi elds of health care and agriculture. Its products and services are designed to benefi t people and improve their quality of life. At the same time, the Group aims to create value through innovation, growth and high earning power. Bayer is committed to the principles of sustainable development and to its social and ethical responsibilities as a corporate citizen. In fi scal 2016, the Group employed around 115,200 people and had sales of EUR 46.8 billion. Capital expenditures amounted to EUR 2.6 billion, R&D expenses to EUR 4.7 billion. These fi gures include those for the high-tech polymers business, which was fl oated on the stock market as an independent company named Covestro on October 6, 2015. For more information, go to www.bayer.us. www.bayer.com GE Healthcare Chicago, IL Harnessing data and analytics across hardware, software and biotech, GE Healthcare