Final Agenda Register by August 7 and Cambridge Healthtech Institute’s SAVE up to Seventh International $350! Discovery on TARGET Diverse Pathways Multiple Targets One Event November 2-4, 2009 InterContinental Hotel, Boston, MA Concurrent Tracks November 2 - 3 KEYNOTE PRESENTERS Seventh Annual SHORT COURSES: Sunday, November 1 David Clapham, M.D., RNAi for Screening Ph.D., Howard Hughes Medical Institute Cellular Pathways and Targets Strategies for Effective RNAi Screens Michael Dabrowski, Ph.D., Third Annual AstraZeneca HDAC Inhibitors Targeting GPCRs Gregory J. Kaczorowski, Ph.D., and Ion Channels with School; Robert Wood Fourth Annual Antibodies Johnson Medical School Ion Channels as Therapeutic Targets John M. Maraganore, Strategies for Optimizing Ph.D., Alnylam RNAi Delivery Pharmaceuticals, Inc. Fourth Annual Graeme Milligan, Ph.D., GPCR-Based Drug Discovery Combating Diabetes with University of Glasgow Strategies for Enhanced Pancreatic Beta Cell Concurrent Tracks November 3 - 4 Steven E. Nissen, M.D., Survival and Regeneration M.A.C.C., Cleveland Clinic Third Annual Foundation RNAi for Developing Structure-Based Design of David Root, Ph.D., The RNAi Ion Channels Consortium Broad Institute of MIT Targeted Therapeutics and Harvard Cardiovascular Safety in Third Annual Anja J. Stauber, Ph.D., DABT, Drug Development - From Eli Lilly and Company Kinase Inhibitors Preclinical to Phase I Eric M. Verdin, M.D., University of California, San Francisco Second Annual Targeting Diabetes with Novel Therapeutics Corporate Sponsors: Lead Sponsoring Publications: Biotechnologies GmbH Cambridge Healthtech Institute • 250 First Avenue, Suite 300, Needham, MA 02494 Telephone: 781-972-5400 or Toll-Free in the U.S. 888-999-6288 • Fax: 781-972-5425 DiscoveryOnTarget.com Image Courtesy of IRBM P.Angeletti Image courtesy of QIAGEN Conference-at-a-Glance HOTEL & TRAVEL INFORMATION SUNDAY, NOVEMBER 1 Conference Hotel: InterContinental Hotel 11:30 am–12:00 pm Registration 510 Atlantic Avenue Boston, MA 02210 12:00 pm–3:00 pm CONCURRENT Short Courses 1 and 2 Tel: 617-747-1000 2:00 pm–3:30 pm Registration Fax: 617-217-5190 3:30 pm–6:30 pm CONCURRENT Short Courses 3/4/5/6 Discounted Room Rate: $249 s/d 4:30 pm–6:30 pm Main Conference Early Registration Room rate includes complimentary internet access Discounted Room Rate Cut-off Date: October 5, 2009 MONDAY, NOVEMBER 2 Please visit our website or call the hotel directly to reserve your sleeping accommodations. Identify yourself as a Cambridge Healthtech Institute conference attendee to receive the reduced room rate. 7:00 am–8:30 am Registration and Morning Coffee Reservations made after the cut-off date or after the group room block 8:30 am–10:10 am CONCURRENT TRACKS 1/2/3/4 has been filled (whichever comes first) will be accepted on a space- and-rate-availability basis. Rooms are limited, so please book early. 10:10 am–10:40 am Grand Opening Coffee Break in the Exhibit Hall 10:40 am–12:40 pm CONCURRENT TRACKS 1/2/3/4 Flight Discounts: To receive a 5% or greater discount on all American Airline flights 12:40 pm–2:20 pm Luncheon Presentations or Lunch on Your Own please use one of the following methods: 2:20 pm–3:55 pm CONCURRENT TRACKS 1/2/3/4 • Call 1-800-433-1790 (authorization code A4819SS). 3:55 pm–4:30 pm Networking Refreshment Break in the • Go online at www.aa.com (enter A4819SS in promotion Exhibit Hall discount box). 4:30 pm–5:45 pm CONCURRENT TRACKS 1/2/3/4 • Contact our designated travel agent, Wendy Levine, at 1-800- 5:30 pm–7:00 pm Happy Hour in the Exhibit Hall 336-5248 ext. 137. Car Rental Discounts: TUESDAY, NOVEMBER 3 Special discount rentals have been established with AVIS for this conference. Please call AVIS directly at 7:30 am–8:30 am Continental Breakfast Breakout Discussion 800-331-1600 and you must reference our Avis Worldwide Sessions Discount (AWD) Number J868190. 8:30 am–9:40 am CONCURRENT TRACKS 1/2/3/4 9:40 am–10:40 am Networking Coffee Break in the Exhibit Hall 10:40 am–12:40 pm CONCURRENT TRACKS 1/2/3/4 12:40 pm Close of Tracks 1/2/3/4 1:00 pm–2:00 pm Registration 2:00 pm–3:40 pm CONCURRENT TRACKS 5/6/7 3:40 pm–4:20 pm Networking Refreshment Break in the Exhibit Hall 4:20 pm–6:20 pm CONCURRENT TRACKS 5/6/7 WEDNESDAY, NOVEMBER 4 7:30 am–8:30 am Continental Breakfast Breakout Discussion Sessions 8:35 am–10:10 am CONCURRENT TRACKS 5/6/7 10:10 am–10:55 am Networking Coffee Break in the Exhibit Hall 10:55 am–12:25 pm CONCURRENT TRACKS 5/6/7 12:25 pm–1:55 pm Luncheon Presentations or Lunch on Your Own 1:55 pm–3:00pm CONCURRENT TRACKS 5/6/7 3:00 pm–3:40 pm Networking Ice Cream Refreshment Break in Exhibit Hall (Last Chance for Viewing) 3:40 pm–5:10 pm CONCURRENT TRACKS 5/6/7 5:10 pm Close of Discovery on Target Summit CHI’s Intro-Net: Networking at its Best! The Intro-Net offers you the opportunity to set up meetings with selected attendees before, Maximize Your Experience Onsite during and after this conference, allowing you to connect to the key people that you want to meet. This online system was designed with your privacy in mind and is only available to at Discovery On Target! registered session attendees of this event. Registered conference attendees will receive more information on how to access the Intro-Net in the weeks leading up to the event! DiscoveryOnTarget.com 32 Online: www.DiscoveryOnTarget.com Email: [email protected] Fax: 781-972-5425 8 * 7 Pre-Conference Short Courses* Sunday, November 1 12:00 pm – 3:00 pm Strategies for Effective RNAi Screens (SC1) Targeting GPCRs and Ion Channels with Antibodies (SC2) This course is designed to provide in-depth information on how to go about This course is designed to be interactive and provide an in-depth update on setting up RNAi screening experiments and how to design assays for getting the potentials and challenges of developing mAB candidates as therapeu- optimal results. The challenges working with different types of molecules i.e. tics for conditions involving membrane proteins. siRNAs, shRNAs and the delivery systems to get them into the appropriate Topics to be covered: cells and tissues will be discussed. The instructors will also provide their in- • Pros and cons of targeting multi-spanning membrane proteins with antibody put on best practices for the execution of experiments and interpretation of approaches results when dealing with complex biology and informatics. • Basic screening technologies for mAB against multi-spanners Topics to be covered: • GPCR challenges such as expression level, post-translational modifications • Overview of assay designs for siRNA and shRNA screens and oligomerization • Testing and validating methods for RNA delivery • Ion channel specific methodologies • Use of appropriate reagents and cell types • Optimizing leads • Implementing proper quality control • Case studies of clinical candidates • Minimizing cytotoxicity and off-target effects Instructor(s): • Data analysis and statistical considerations Tajib A. Mirzabekov, Ph.D., President & Chief Executive Officer, MSM Protein Instructor(s): Technologies, Inc. Christophe J. Echeverri, Ph.D., CEO/CSO, Cenix BioScience GmbH Rajan Dighe, Ph.D., Professor, Molecular Reproduction, Development and Genetics, Karol Kozak, Database Handling Unit, High Content Screening, LMC-RISC, ETH Zurich Indian Institute of Science Caroline Shamu, Ph.D., Director, ICCB-Longwood Screening Facility, Harvard Medical School Markus Delling, Ph.D., Instructor, Howard Hughes Medical Institute and Childrens Hospital Boston Cardiovascular Research, Harvard Medical School 3:30 pm – 6:30 pm Structure-Based Design of Ion Channels (SC5) Strategies for Optimizing RNAi Delivery (SC3) Topics to be covered: This course is designed to provide both the beginner and the expert with • Overview of current technologies a comprehensive overview of current and emerging delivery systems and • Human vs animal channels – how comparable are they? formulations facilitating RNAi delivery. Various methods for RNAi delivery • High-throughput screening of ion channel inhibitors such as viral vectors, liposomes, nanoparticles, chemical conjugates and • Automated Patch Clamp for Ion Channel Screenings other commonly used techniques will be compared and contrasted for dif- • Channel Gating of Potassium Channels ferent applications. The instructors will also discuss the challenges associ- Instructors: ated with RNAi delivery, both in vitro and in vivo, and offer guidance based Chris Mathes, Ph.D., Vice-president & General Manager, Sophion Bioscience, Inc. on their knowledge and expertise in the field. Dan Minor, Ph.D., Associate Professor, Departments of Biochemistry & Topics to be covered: Biophysics and Cellular & Molecular Pharmacology; Investigator, Cardiovascular • Testing and validating methods for delivery Research Institute, California Institute for Quantitative Biomedical Research, • Overview of viral and non-viral vector systems University of California, San Francisco • Chemical methods of improving delivery • New formulations to optimize delivery • Minimizing cytotoxicity and off-target effects • Examining tissue distribution and safety profiles Instructor(s): Roger Adami, Ph.D., Associate Director, Molecular Pharmaceutics, MDRNA, Inc. Derek M. Dykxhoorn, Ph.D., Assistant Professor of Human Genetics and Microbiology and Immunology, University of Miami School of Medicine Muthiah Manoharan, Ph.D., Vice President, Drug Discovery, Alnylam Pharmaceuticals, Inc. *Separate Registration Required Sponsoring Publications: DiscoveryOnTarget.com 3 Online: www.DiscoveryOnTarget.com