USOO7745.391 B2 (12) United States Patent (10) Patent No.: US 7,745,391 B2 Mintz et al. (45) Date of Patent: Jun. 29, 2010 (54) HUMAN THROMBOSPONDIN POLYPEPTIDE 5,283,317. A 2/1994 Saifer et al. 5,288,514. A 2/1994 Ellman (75) Inventors: Liat Mintz, East Brunswick, NJ (US); 5,328,470 A 7, 1994 Nabel et al. Hanging Xie, Lambertville, NJ (US); 5,384,261 A 1/1995 Winkler et al. Dvir Dahary, Tel-Aviv (IL); Erez 5,459,039 A 10/1995 Modrich et al. Levanon, Petach-Tikva (IL), Shiri 5,475,092 A 12/1995 Charietal. Freilich, Herzlia (IL); Nili Beck, Kfar 5,498,531 A 3, 1996 Jarrell Saba (IL); Wei-Yong Zhu, Plainsboro, 5,510,270 A 4/1996 Fodor et al. E"ESNI)s s 379- J. A ROMomoglio is et al.a (73) Assignee: Compugen Ltd., Tel-Aviv (IL) 5,585,089 A 12/1996 Queen et al. 5,585.499 A 12/1996 Chari et al. (*) Notice: Subject to any disclaimer, the term of this 5,631, 169 A 5/1997 Lakowicz et al. patent is extended or adjusted under 35 5,693,761 A 12/1997 Queen et al. 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