Europaisches Patentamt European Patent Office © Publication number: 0 346 883 A3 Dffice europeen des brevets © EUROPEAN PATENT APPLICATION © Application number: 89110822.7 © Int. CI.5: A61 K 31/195 © Date of filing: 14.06.89 © Priority: 16.06.88 JP 148653/88 © Applicant: SS PHARMACEUTICAL CO., LTD. 2-12-4 Nihonbashi Hama-cho Chuo-ku @ Date of publication of application: Tokyo(JP) 20.12.89 Bulletin 89/51 © Inventor: Itoh, Yoshikuni © Designated Contracting States: 405, Hiyoshikura Tomisato-machi BE CH DE ES FR GB IT LI NL SE Inba-gun Chiba-ken(JP) Inventor: Mizuno, Miroyuku ® Date of deferred publication of the search report: 1-24-19, Hiyoshidai Tomisato-machi 10.10.90 Bulletin 90/41 Inba-gun Chiba-ken(JP) Inventor: Kiyohara,Chikako 6-14-10, Sodegaura Narashino-shi Chiba-ken(JP) Inventor: Sato, Susumu 6-6-9-503, Higashishisui Shisui-machi Inba-gun Chiba-ken(JP) Inventor: Katori, Tatsuhiko 3081-11, Fukawa Tone-machi Kitasouma-gun Ibaraki-ken(JP) © Representative: Wachtershauser, GUnter, Dr. Tal 29 D-8000 Miinchen 2(DE) © Expectorant comprising hydroxy-alkylcysteine derivative. © An expectorant comprising a hydroxyalkylcysteine derivative of the following formula (I) is disclosed. I m HO-( CH2 ) n-S-CH2CHCOOH ( ) < I 1 CO , CO 00 CO wherein n represents an integer of 1 to 4. The expectorant is stabile, has little side effects and toxicity, and ''f exhibits an excellent expectorant effect. CO o Q. LU Xerox Copy Centre Patent uropean UKUf fcATN atAK^rt ffice r J. a. uucl. >OCUMENTS CUINSIUKKIUJ 1U DtL KiLmvAm itahon ot document wkii inaicaiioii, micrc aypiuH"<"c» PP11CATION CI. 4) ategory of relevant passages > claim (Int. S-A-4 096 277 Q I .A. MAKI1N et ai.j Abstract; column 1, lines 42-68; Dlumn 2, lines 1-40 * JOULLIE et a.) i S-A-3 891 749 (M.L. Column 1; claims * \ B-B-l 418 208 (RECHERCHES HARMACEUTIQUES ET SCIENTIFIQUES) Page 1; page 2, preparation 1; page 18-41 * , lines NTERNATIONAL JOURNAL OF CLINICAL HARMAC0L0GY, THERAPHY AND TOXICOLOGY, ol. 20, no. 11, 1982, pages 554-557; "Double-blind . CASALI et al.: linical trial of domiodol vx -carboxymethyl cysteine in chronic bstructive lung disease" Whole article * SEARCHED (Int. C1.4) 0URNAL OF PHARMACEUTICAL SCIENCES, ol. 50, no. 4, April 1961, pages 12-315; M. VERDERAME: "Sulfide lerivatives of cysteine" : Whole article * The present search report nas oeen arawn up ior an ™uus V lace ot searcn THE HAGUE 26-07-1990 E : earlier patent document, but published on, or X : particularly relevant if taken alone after the filing date Y : particularly relevant if combined with another D : document cited in the application document of the same category L : document cited for other reasons A : technological background corresponding 0 : non-written disclosure & : member of the same patent family, P : intermediate document document .