Stress and the skin: exploring the associations between perceived stress and self-reported skin symptoms and signs Thomas Jonathan Stewart A thesis in fulfilment of the requirements for the degree of Master of Medicine (by research) School of Medicine Faculty of Medicine November 2018 1 INCLUSION OF PUBLICATIONS STATEMENT UNSW is supportive of candidates publishing their research results during their candidature as detailed in the UNSW Thesis Examination Procedure. 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This thesis contains no publications, either published or submitted for publication ☐ (if this box is checked, you may delete all the material on page 2) Some of the work described in this thesis has been published and it has been documented in the relevant Chapters with acknowledgement (if this box is ☐ checked, you may delete all the material on page 2) This thesis has publications (either published or submitted for publication) ☐ incorporated into it in lieu of a chapter and the details are presented below CANDIDATE’S DECLARATION I declare that: • I have complied with the Thesis Examination Procedure • where I have used a publication in lieu of a Chapter, the listed publication(s) below meet(s) the requirements to be included in the thesis. Name Signature Date (dd/mm/yy) Postgraduate Coordinator’s Declaration (to be filled in where publications are used in lieu of Chapters) I declare that: • the information below is accurate • where listed publication(s) have been used in lieu of Chapter(s), their use complies with the Thesis Examination Procedure • the minimum requirements for the format of the thesis have been met. 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You may delete any boxes not used ii THE UNIVERSITY OF NEW SOUTH WALES Thesis/Dissertation Sheet Surname or Family name: Stewart First name: Thomas Abbreviation for degree as given in the University calendar: MRes School: Medicine Faculty: Health Title: Stress and the skin: exploring the associations between perceived stress and self-reported skin symptoms and signs Abstract Background & Aims: A connection between psychological stress and the skin has been recognised for many years. Although laboratory-based research has uncovered sound pathogenic mechanisms and clinical research has successfully linked stress with a number of skin diseases, less has been made of the skin symptoms and signs that are experienced in the non-healthcare seeking population in association with stress. This thesis aims to assess whether increased levels of perceived psychological stress are associated with presence of skin symptoms and signs in Australian university students. Methods: A comprehensive review of the literature on the associations between stress and established skin diseases was undertaken. This review examined proposed underlying pathologic mechanisms as well as clinical studies investigating the relationships between perceived stress and skin disease. After institutional approval, an electronic cross-sectional survey using the validated Perceived Stress Questionnaire and a modified Self-Reported Skin Questionnaire, was distributed to 5000 students at a single university. The results of these questionnaires were analysed using logistic regression to assess whether increased levels of perceived psychological stress are associated with presence of the studied skin symptoms and signs. Results: 471 participants successfully completed the survey and were included in the study. Subjects with higher levels of stress were statistically significantly more likely to report the presence of itch 2 (p<0.001), dry/sore rash (p<0.001), scaly skin (p<0.001), hair loss (p<0.001), other rashes on face (p<0.001), itchy rash on hands (p<0.001), troublesome sweating (p=0.003) or hair-pulling (p<0.001). No association was found between stress and: pimples, oily/waxy patches on scalp or flakey scalp, warts, or nail-biting. The results are discussed with reference to the existing literature on skin symptoms, signs and diseases. Conclusion: The results support the hypothesis that an increase in perceived stress is associated with an increased likelihood of self-reporting a number of skin symptoms and signs in a nonhealthcare-seeking population. These findings may have significant implications for the self- management of skin morbidity with coexistent stress. The utility of perceived stress- and skin symptom- and sign-based tools in psychodermatology research is not yet fully elucidated. Declaration relating to disposition of project thesis/dissertation I hereby grant to the University of New South Wales or its agents the right to archive and to make available my thesis or dissertation in whole or in part in the University libraries in all forms of media, now or here after known, subject to the provisions of the Copyright Act 1968. I retain all property rights, such as patent rights. I also retain the right to use in future works (such as articles or books) all or part of this thesis or dissertation. I also authorise University Microfilms to use the 350 word abstract of my thesis in Dissertation Abstracts International (this is applicable to doctoral theses only). .............................. .................................. ………………………. 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I also authorise University Microfilms to use the 350 word abstract of my thesis in Dissertation Abstract International (this is applicable to doctoral theses only). I have either used no substantial portions of copyright material in my thesis or I have obtained permission to use copyright material; where permission has not been granted I have applied/will apply for a partial restriction of the digital copy of my thesis or dissertation.' Signed ......................................... Date ………................................ AUTHENTICITY STATEMENT ‘I certify that the Library deposit digital copy is a direct equivalent of the final officially approved version of my thesis. No emendation of content has occurred and if there are any minor variations in formatting, they are the result of the conversion to digital format.’ Signed ......................................... 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