Table 2 Genes with higher mRNA levels in the control group Bos taurus Homo sapiens Accession q -value Gene description of best BLAST hit Gene symbol gene ID gene ID number Fold up (%) Score (d) Cyc Function/biological process H.s. alpha 1,4-galactosyltransferase A4GALT 53947 NM_017436 -4,2 0,00 -4,54 glycosphingolipid biosynthesis B.t. mRNA for similar to alpha 2 actin ACTA2 281593 59 AB098797 -2,7 0,00 -4,38 x cytoskeleton B.t. actin, beta ACTB 280979 60 NM_173979 -2,2 0,25 -2,67 x cytoskeleton B.t. a disintegrin-like and metalloprotease with thrombospondin type 1 motif, 4 ADAMTS4 286806 9507 NM_181667 -5,0 0,22 -2,88 ECM remodeling B.t. annexin A2 ANXA2 282689 302 NM_174716 -2,4 0,21 -2,87 x ECM remodeling B.t. dynein heavy chain ; dynein, axonemal, heavy polypeptide 11 [H.s.] Bv1 (DNAH11) 497208 8701 U63924 -2,3 0,50 -2,43 cytoskeleton B.t. calbindin 3, (vitamin D-dependent calcium binding protein) CALB3 (S100G) 281658 795 NM_174257 -3,1 0,21 -2,78 calcium absorption H.s. chondroitin polymerizing factor CHPF 79586 NM_024536 -2,5 0,00 -3,41 ECM remodeling H.s. cytoskeleton-associated protein 4 CKAP4 10970 NM_006825 -5,0 0,00 -3,44 cytoskeleton organization B.t. claudin 10 CLDN10 506545 9071 BT020910 -7,8 1,27 -1,97 x cell adhesion H.s. collagen, type I, alpha 1 COL1A1 282187 1277 NM_000088 -4,4 0,00 -3,86 x ECM protein B.t. collagen, type I, alpha 2 COL1A2 282188 1278 NM_174520 -3,2 0,20 -2,86 x ECM protein B.t. type III pro-collagen gene COL3A1 282190 1281 L47641 -3,1 0,08 -3,32 x ECM protein H.s. collagen, type IV, alpha 2 COL4A2 497192 1284 NM_001846 -3,5 0,00 -5,49 x ECM protein H.s. collagen, type VI, alpha 1 COL6A1 282193 1291 NM_001848 -2,3 0,00 -3,37 x ECM protein H.s. collagen, type VI, alpha 2 COL6A2 282194 1292 NM_058175 -2,0 0,12 -3,21 x ECM protein H.s. collagen, type VI, alpha 3 COL6A3 1293 NM_004369 -5,8 0,00 -4,35 x ECM protein H.s. collagen, type XV, alpha 1 COL15A1 1306 NM_001855 -4,2 0,03 -4,66 x ECM protein B.t. cDNA; LCCL domain containing cysteine-rich secretory protein 2 [H.s.] CRISPLD2 83716 CK832702 -2,9 0,00 -4,44 unknown H.s. deiodinase, iodothyronine, type II DIO2 494548 1734 NM_013989 -2,3 0,00 -3,78 thyroid hormone activation B.t. DnaJ (Hsp40) homolog, subfamily B, member 11 DNAJB11 506316 51726 NM_001034268 -2,3 0,22 -2,79 protein folding H.s. dystonin DST 667 NM_183380 -2,1 0,67 -2,08 cytoskeleton organization H.s. deltex 4 homolog (Drosophila) DTX4 23220 BC015592 -4,4 0,00 -4,46 protein ubiquitination? B.t. estrogen receptor 1 alpha ESR1 281145 2099 AY656813 -3,0 0,06 -3,74 transcription factor H.s. mRNA; cDNA DKFZp762L0811; fatty acid desaturase 1 [H.s.] FADS1 533107 3992 AL834479 -2,4 0,12 -2,91 fatty acid metabolism H.s. fibulin 1 FBLN1 2192 NM_006487 -2,2 0,67 -2,19 x ECM, cell adhesion H.s. hypothetical protein FLJ14054 FLJ14054 79614 NM_024563 -6,2 0,00 -5,19 unknown B.t. filamin A FLNA 281165 2316 AY072716 -3,3 0,00 -4,34 cytoskeleton organization H.s. growth arrest and DNA-damage-inducible, gamma GADD45G 10912 NM_006705 -9,8 0,00 -8,10 differentiation, coactivator of ESR1? similar to B.t. gastrin-releasing peptide (94%) GRP-like* 280809 2922 NM_178319 -2,2 0,11 -3,13 signal transduction B.t. partial mRNA for heat shock 70kDa protein 5 (grp78 gene) HSPA5 281829 3309 AJ586431 -2,6 0,14 -2,92 ER chaperone 4123573 BARC 8BOV B.t. cDNA; H.s. IBR domain containing 2 IBRDC2 255488 CN789149 -2,5 0,39 -2,38 target of p53, E3 ubiquitin ligase H.s. insulin-like growth factor 1 (somatomedin C) IGF1 281239 3479 NM_000618 -2,4 0,22 -2,79 growth factor H.s. tubulin, alpha, ubiquitous K-ALPHA-1 10376 NM_006082 -2,4 0,00 -3,54 cytoskeleton H.s. KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 KDELR2 11014 NM_006854 -2,1 0,22 -2,62 sorting receptor H.s. KIAA2010 KIAA2010 55671 NM_032560 -3,0 0,12 -2,91 unknown PREDICTED: B.t. similar to Laminin beta-1 chain precursor (Laminin B1 chain) LAMB1 520030 3912 XM_598260 -2,1 0,39 -2,39 cell adhesion B.t. lactate dehydrogenase A LDHA 281274 3939 NM_174099 -2,0 0,31 -2,49 anaerobic glycolysis H.s. melanoma antigen family D, 1 MAGED1 512562 9500 NM_001005333 -2,9 0,12 -3,12 x apoptosis-related Bos grunniens metallothionein-2 MT2A 404070 4502 AY513745 -6,3 0,31 -2,54 metal ion binding H.s. myosin, light polypeptide kinase MYLK 338037 4638 NM_053025 -3,0 0,06 -3,61 cytoskeleton organization B.t. oxytocin receptor OXTR 281371 5021 NM_174134 -120 0,00 -9,32 luteolysis H.s. polo-like kinase 2 PLK2 10769 NM_006622 -6,6 0,00 -6,38 signal transduction H.s. protease, serine, 11 (IGF binding) PRSS11 (HTRA1) 282326 5654 NM_002775 -2,7 0,00 -4,09 x signal transduction PREDICTED: B.t. similar to transcription factor RAM2 (LOC514631) RAM2 (CDCA7L) 514631 55536 XM_592513 -2,3 0,31 -2,56 x transcription factor H.s. retinoic acid receptor responder 1 RARRES1 5918 NM_206963 -2,4 0,12 -3,01 x inhibition of proliferation B.t. retinol binding protein 4, plasma RBP4 281444 5950 S65585 -2,8 0,04 -3,46 retinol carrier H.s. syndecan 2 SDC2 615785 6383 NM_002998 -2,6 0,52 -2,35 cell-matrix interaction PREDICTED: B.t. similar to Sec61 alpha subunit homolog (LOC505064) SEC61A1 505064 29927 XM_581292 -2,1 0,27 -3,44 x transport H.s. serine (or cysteine) proteinase inhibitor, clade H, member 1 SERPINH1 871 NM_001235 -2,7 0,00 -3,54 x collagen maturation H.s. splicing factor, arginine/serine-rich 10 SFRS10 615156 6434 NM_004593 -2,5 0,00 -3,71 pre-mRNA splicing H.s. SPARC related modular calcium binding 2 SMOC2 64094 NM_022138 -3,3 0,17 -2,87 ECM protein H.s. SRY (sex determining region Y)-box 4 SOX4 6659 NM_003107 -3,2 0,12 -2,98 x transcription factor B.t. secreted protein, acidic, cysteine-rich [osteonectin] SPARC 282077 6678 NM_174464 -3,0 0,00 -3,79 x ECM protein H.s. stanniocalcin 1 STC1 338078 6781 NM_003155 -2,5 1,03 -1,68 luteinization inhibitor H.s. stimulated by retinoic acid gene 6 homolog STRA6 64220 NM_022369 -3,5 0,00 -3,84 RA signaling Bovine preprotachykinin B gene, exon 7; H.s. tachykinin 3 TAC3 281513 6866 M14352 -3,0 1,03 -1,73 vasodilator B.t. thrombospondin THBS 281530 7057 NM_174196 -4,7 0,39 -2,37 x ECM protein B.t. thrombospondin 2 THBS2 338092 7058 NM_176872 -2,5 0,00 -4,13 ECM protein B.t. tissue inhibitor of metalloproteinase 1 TIMP1 282092 7076 NM_174471 -5,8 0,00 -3,95 ECM remodeling H.s. transmembrane, prostate androgen induced TMEPAI 56937 NM_020182 -4,7 0,00 -4,62 TGF-beta induced H.s. tenascin C (hexabrachion) TNC 3371 NM_002160 -13,5 0,02 -3,97 x ECM protein H.s. tubulin, beta polypeptide TUBB 203068 NM_178014 -3,0 0,03 -3,94 x cytoskeleton B.t. tubulin, beta polypeptide (TUBB) TUBB (TUBB2A) 281555 7280 NM_001003900 -2,3 0,10 -3,76 cytoskeleton B.t. tubulin, beta polypeptide; H.s. tubulin, beta 6 TUBB6 84617 NM_001003900 -3,0 0,00 -4,09 cytoskeleton H.s. unc-5 homolog B UNC5B 219699 NM_170744 -3,4 0,85 -1,89 signal transduction B.t. cDNA; zinc finger protein 703 ZNF703 80139 CO887790 -2,0 0,67 -2,19 unknown H.s. zyxin ZYX 617259 7791 NM_003461 -2,3 0,22 -2,74 cell adhesion PREDICTED: B.t. hypothetical LOC509824 509824 XM_586871 -2,2 0,94 -1,84 unknown B.t. cDNA; Chr. 8 60817035-60817713 DT837144 -5,3 0,64 -2,17 H.s. Homo sapiens , B.s. Bos taurus ; Gene symbols given in parentheses represent Homo sapiens gene name if differing; * no official gene symbol; Cyc genes previously detected as up-regulated in the bovine endometrium at oestrus during oestrous cycle (Bauersachs 2005).