10th World Cleft Lip, Palate & Craniofacial Congress Diagnosis, Prevention, Genetics & Management of Cleft & Craniofacial Deformities Current Techniques, Research & Future Directions Transactions of 10th World Cleft Lip, Palate & Craniofacial Congress of International Cleft Lip and Palate Foundation (ICPF) Pre-Conference Live Surgical Workshop October 24 & 25, 2016 Balaji Dental & Craniofacial Hospital, Chennai, India Main Conference October 26-28, 2016 Hyatt Regency, Chennai, India Edited By : Prof. S.M. Balaji, MDS, PhD., DSc., 1 10th World Cleft Lip, Palate & Craniofacial Congress 10th World Cleft Lip, Palate & Craniofacial Congress Congress Secretariat: Balaji Dental & Craniofacial Hospital, 30, KB Dasan Road, Teynampet, Chennai, India Ph: 044-4294 7222 E-mail : [email protected] 2 10th World Cleft Lip, Palate & Craniofacial Congress Foreword Dear Colleagues, It is my pleasure and honor to bring out the official record of the scientific proceedings and transactions of the 10th World Cleft Lip and Palate Conference held in Chennai, India. The official programs of this meeting, held under the aegis of International Cleft Lip and Palate Foundation includes diverse, multidisciplinary proceedings in the management of cleft lip and palate. This record and documentation of the happenings of the meeting would serve as a ready source of reference for all orations, invited talks and free scientific presentations. Most of the research work and experience shared in conferences are often not published in open domains and remains untraceable. It is the proceedings that officially document such valuable knowledge that serves a ready reference for future generations. The treatment options in the domain of surgery, occlusion rehabilitation, speech, and genetics have undergone rapid modification in the last few years. Such modifications results in large series of research manuscripts across the globe. The deeper understanding of the etiopathogeneisis, utilization of biomimetics and tissue engineering are creating new avenues of research. With expanding cleft networks and voluntary missions, even in remotest area and in limited resources settings, newer cost effective protocols are being evolved. These protocols are being presented and discussed in this meeting. I believe that this compilation have reflected the true nature of the International Cleft Lip and Palate Foundation. I am sure that this book will serve as a worthwhile Withreminder best regardsof all the scientific progress achieved through this meeting. Prof. S.M. Balaji Congress President 10th World Cleft Lip, Palate & Craniofacial Congress 3 10th World Cleft Lip, Palate & Craniofacial Congress CONTENTS Prof. Kenneth Salyer, USA............................................................................................................................................................ ICPF Presidential Oration - Global Craniofacial Care: 45 Year Personal Perspective 013 Prof. Anthony Markus, UK............................................................................................................................................................ Prof. David Precious Memorial Oration - David Precious - A Celebration 015 Prof. M. S. AnthonyS. Ramakrishnan Wolfe, MemorialUSA Oration - Pediatric Plastic Surgery becomes Craniofacial Surgery, t hanks to Paul Tessier ............................................................................................................................................................................ 016 Prof. Dr.Dr. C. GE R. Ghali, Sundararajan USA................................................................................................................................................................... Memorial Oration - EXIT (Ex Utero Intrapartum Treatment) Procedure: A Modality f or the Airway Management of the Select Cleft and Craniofacial Patient Population 017 Prof. Dr.Dr. Kawai Adrian Memorial Sugar, UK........................................................................................................................................................... Oration - Orthognathic Surgery and Alveolar Bone Grafting in Cleft Lip and Palate Patients 019 Prof. Dr.Dr. J. NR G. KannappanKrishnaswamy, Memorial India............................................................................................................................................. Oration - Management of patients with cleft lip and palate - The Orthodontist’s Perspective 021 Prof. Dr. S.M. Balaji, India............................................................................................................................................................ Prof. Dr. U. S. Nayak Memorial Oration - Lip to Cranium 022 Sai Shamini, India ANAMAYA IndoPacific Cleft Prevention Program: Shifting the attention to prevention of cleft lip and palate 026 Karthika Panneerselvam, India................................................................................................................................................. 028 Review of studies on a role of folic acid in etiology and prevention of cleft lip and palate Viviana Armentano, Argentina.................................................................................................................................................. 030 The role of medical geneticist in prevention of cleft lip and palate - Nagato Natsume, Japan................................................................................................................................................................. 032 Preventive research on cleft lip and palate in Japan - Nagato Natsume, Japan................................................................................................................................................................. 033 International Collaboration for Cleft Lip and/or palate from Japan KangminAhn, S. Korea................................................................................................................................................................... 035 PTCH1 gene mutation in nevoid basal cell carcinoma syndromewith diverse clinical manifestations Kaori Matsumura, Japan ............................................................................................................................................................. 036 Microarray analysis of global gene expression during palate development Ashwin Dalal, India ........................................................................................................................................................................ Genetic Testing for Diagnosis of Craniofacial defects: Methods and Indications 038 Shankar VH, India .......................................................................................................................................................................... 039 Medical Genetics in Craniofacial Clinical Practice: Indian Scenario Takeshi"Cleft lip Mitsuyasu& palate treatment , Japan........................................................................................................................................................... team in Kyushu University Hospital, Fukuoka Japan -Prenatal counseling and visiting on birth day - 040 Sunil Kumar Rout, India............................................................................................................................................................... Cleft palate repair – Not just closing the gap - 041 Aysegul M. Tuzuner, Turkey....................................................................................................................................................... 043 Cleft Lip and Palate Care, Our Clinical perspectives Jesus Andrés Duque, Colombia.................................................................................................................................................. 047 Deleare Approach For Cleft Lip And Palate Our Experience Piranit Nik Kantaputra, Thailand ............................................................................................................................................. 048 Orofacial Clefting and Dental Anomalies - 4 10th World Cleft Lip, Palate & Craniofacial Congress Siddaramappa Jagdish Patil, India.............................................................................................................................................. 050 Genetic studies in orofacial clefts Girisha KM, India............................................................................................................................................................................. 051 Approach to a case with orofacial cleft: Clinical genetics perspective MirekEarly response Tolar, USA............................................................................................................................................................................. of human mesenchymal stem cells to mechanical force and supplyof oxygen – research 052 and clinical perspectives Kazuto Hoshi, Japan ..................................................................................................................................................................... 054 Three-dimensional tissue-engineered cartilage using biodegradable polymers Thomas"Clinical outcomeEngstrand, and Sweden........................................................................................................................................................ bone regenerative effects from using calcium phosphate-basedimplants