springer.com Biomedicine : Human Genetics Bott, Richard, Betzel, Christian (Eds.) Subtilisin Enzymes Practical Protein Engineering Subtilisin is the most extensively studied model system for protein engineering. The primary motivating factor for the interest in subtilisin is the commercial utility of this class of proteases. The subtilisin symposium was the first international meeting to bring together a large number of groups that have focused on the subtilisins and the subtilases-the protein superfamily of subtilisin-like enzymes. The results presented at the symposium are in this way a unique compendium of a broad spectrum of work largely focused on harnessing the potential of site- directed mutagenesis to understand and deliberately alter the function of these enzymes toward a desired end. This sort of protein engineering has been extremely successful in subtilisin, with many such "engineered" enzymes now widely used in commer• cial enterprises. In this regard the experience derived from subtilisin does represent practical protein engineering. It is becoming clear that subtilisin represents a larger class of enzymes, the Springer subtilases, that include many of the human pro hormone-converting enzymes. As international Softcover reprint of the collabo• rative efforts to sequence entire genomes continue, we can reasonably expect that 1st original 1st ed. 1996, XI, edition additional members of the subtilase class will be encountered. Whenever interest in a member 288 p. of this class of enzyme arises, the work on subtilisin will serve as a guide to the analysis for what in bacillus, fungi, and industry is an everyday workhorse enzyme. Printed book Softcover Order online at springer.com/booksellers Springer Nature Customer Service Center LLC Printed book 233 Spring Street Softcover New York, NY 10013 ISBN 978-1-4613-7995-9 USA $ 149,99 T: +1-800-SPRINGER NATURE (777-4643) or 212-460-1500 Available [email protected] Discount group Professional Books (2) Product category Contributed volume Series Advances in Experimental Medicine and Biology Other renditions Softcover ISBN 978-1-4613-0320-6 Prices and other details are subject to change without notice. All errors and omissions excepted. Americas: Tax will be added where applicable. Canadian residents please add PST, QST or GST. Please add $5.00 for shipping one book and $ 1.00 for each additional book. Outside the US and Canada add $ 10.00 for first book, $5.00 for each additional book. If an order cannot be fulfilled within 90 days, payment will be refunded upon request. Prices are payable in US currency or its equivalent. ISBN 978-1-4613-7995-9 / BIC: MFN / SPRINGER NATURE: SCB12008 Part of .