OriGene Technologies, Inc. OriGene Technologies GmbH 9620 Medical Center Drive, Ste 200 Schillerstr. 5 Rockville, MD 20850 32052 Herford UNITED STATES GERMANY Phone: +1-888-267-4436 Phone: +49-5221-34606-0 Fax: +1-301-340-8606 Fax: +49-5221-34606-11 [email protected] [email protected] AM06537SU-N Monoclonal Antibody to TAB2 / MAP3K7IP2 - Ascites Alternate names: Mitogen-activated protein kinase kinase kinase 7-interacting protein 2, TAK1-binding protein 2, Tab-2 Quantity: 0.1 ml Background: The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Uniprot ID: Q9NYJ8 NCBI: NP_055908.1 GeneID: 23118 Host / Isotype: Mouse / IgG1 Clone: 3B5 Immunogen: Purified recombinant fragment of Human TAB2 expressed in E. Coli. Format: State: Ascitic fluid containing 0.03% Sodium Azide. Applications: ELISA: 1/10000. Western Blot: 1/500 - 1/2000. Flow Cytometry: 1/200 - 1/400. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user. Molecular Weight: 80 kDa Specificity: Recognizes TAB2 / MAP3K7IP2 Species Reactivity: Tested: Human. Storage: Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. General Readings: 1. J Clin Endocrinol Metab. 2006 Mar;91(3):1056-61. 2. Sci STKE. 2006 Oct 17;2006(357):re13. 3. Am J Hum Genet. 2010 Jun 11;86(6):839-49. For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. OG/20130514 1 / 2 AM06537SU-N: Monoclonal Antibody to TAB2 / MAP3K7IP2 - Ascites Pictures: Western blot analysis using TAB2 antibody Cat.-No AM06537SU-N against HEK293 (1) and TAB2(AA: 1-300)-hIgGFc transfected HEK293 (2) cell lysate. Flow cytometric analysis of HL-60 cells using TAB2 antibody Cat.-No AM06537SU- N (green) and negative control (purple). For research and in vitro use only. Not for diagnostic or therapeutic work. Material Safety Datasheets are available at www.acris-antibodies.com or on request. OG/20130514 2 / 2 Powered by TCPDF (www.tcpdf.org).