Dulaglutide Pen Device Was Preferred Based on Usability and Satisfaction. Demonstration Was Fastest, but Least Accurate, with the Dulaglutide Pen Device

Dulaglutide Pen Device Was Preferred Based on Usability and Satisfaction. Demonstration Was Fastest, but Least Accurate, with the Dulaglutide Pen Device

Comparison of Usability, Accuracy, Preference, and Satisfaction Between Three Once-Weekly GLP-1 Receptor Agonist Pen Devices in Patients with Type 2 Diabetes Sara A. Wettergreen, PharmD, BCACP1; Morgan P. Stewart, PharmD, BCACP2; Katelyn Kennedy, PharmD Candidate1; Jennifer M. Trujillo, PharmD, FCCP, BCPS, CDCES, BC-ADM1 1: University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences; 2: University of Texas at Austin College of Pharmacy Background Results Methods *Indicates significance (p-value <0.05) • The study design was a multi-center, • GLP-1 receptor agonists (GLP-1 RAs) Satisfaction Responses prospective cohort study. are widely used in the treatment of type Demographic (N=60) n (%) Response Age (mean age) 61 years 1 2 3 4 5 6 7 • GLP-1 RA pen devices were compared 2 diabetes (T2D). Very Unsatisfied Somewhat Neutral Somewhat Gender 30 (50%) Male Satisfied Very Unsatisfied for time and accuracy of administration, • Design varies among GLP-1 RA pen Race 39 (65%) White/Caucasian 6.4 * user satisfaction, and preference devices, which impacts usability and Previous use of a non-GLP-1 Comfort Using Device 5.7 * 26 (43.3%) 5.5 ratings as primary outcomes. ultimately patient satisfaction, dosing RA injectable agent Education 22 (36.7%) College – graduate level accuracy, and medication adherence.1 • Detailed methods are available in the Health Literacy (HL) Score: Limited HL Possibly Adequate HL 6.7 * supplemental materials. Newest Vital Signs^ limited HL Time to Prepare Device 5.8 • Pen devices and pharmacologic options * * for once-weekly GLP-1 RAs have 10 (16.7%) 12 (20%) 38 (63.3%) 5.2 changed since 2016, and no study has Exenatide XR Dulaglutide Semaglutide Statistical 6.4 BCise (9 steps) (11 steps) Comparison Overall Experience 5.7 * compared usability and patient (9 steps) * Discussion preferences between the three once- 5.2 p <0.001 D vs E Accuracy (mean, • Most study participants preferred the weekly GLP-1 RA devices currently 62.7% 74.4% 73.1% p <0.001 D vs S % steps correct) Dulaglutide Semaglutide Exenatide XR BCise available. p =0.826 E vs S dulaglutide pen based on satisfaction p <0.001 D vs E and usability. • Results of this study may aid clinicians Time to complete p <0.001 D vs S 69 sec 126 sec 146 sec Usability Responses in the decision-making process when (mean, seconds) p =0.08 E vs S • While dulaglutide took the least amount 1 2 3 4 5 of time to demonstrate use, it also had selecting a specific GLP-1 RA agent. Accuracy p-values are adjusted for multiple comparisons using Tukey's adjustment and Very Difficult Difficult Neutral Easy Very from univariate mixed models; Easy least accurate administration. Time to complete p-values result from univariate generalized linear mixed model 4.7 Mixing the Medication 4.5 4.1 * * • The number of steps of demonstration 4.7 varied for each pen device. Missing a Research Question Which pen device did you Removing Needlecap or Cover 4.3 * 3.8 * * single step when there were less steps prefer the most? 4.8 overall could have impacted accuracy How do three once-weekly Injecting the Medication 4.3 * * 12% 4.3 ratings. GLP-1 RA pen devices 4.7 13% Knowing Injection is Complete 4.2 * * compare with respect to 3.9 References 4.5 Understanding the Instructions 3.8 * 1. Toscana D, Brice J, Alfaro C. Usage and perceptions of pen usability, accuracy, 3.9 * 75% injectors for diabetes management: a survey of type 2 diabetes satisfaction, and patient 4.6 in the United States. J Diabetes Sci Technol. 2012;6:686-694. Overall Ease of Use 3.9 * * 2. Zhou AY, Trujillo JM. Comparison of Usability, Accuracy, 3.7 Preference, and Satisfaction Among Three Once-Weekly GLP-1 preferences? Receptor Agonist Pen Devices. Diabetes Spectr. 2018 Dulaglutide Semaglutide Exenatide XR BCise Dulaglutide Semaglutide Exenatide XR BCise Nov;31(4):359-366. Dulaglutide pen device was preferred based on usability and satisfaction. Demonstration was fastest, but least accurate, with the dulaglutide pen device..

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