IMMUNITY DIGESTION NUTRITION BEHAVIOR DIET NEUROLOGIC METABOLISM Underlying Predispositions Including Problems With: Gut flora, Digestion, Absorption, Utilization, Metabolism, Detoxification, Nutrition, Sulfation, Methylation, Oxidation The Total Load Diet, Lifestyle, Environment, Toxins, Medications TRIGGER THE TIPPING POINT ASD DIAGNOSIS REACTIONS TO Foods, Additives, Dyes, Toxins, Pesticides, Medications, Vaccines, Environmental Exposures 1 Remove offending foods and substances What Interferes Gluten, milk casein, soy, corn, phenols, oxalates, starches & sugars Antacids Inflammation Artificial additives, chemicals, pesticides, toxins Antibiotics Poor gut flora Pathogens Toxins Replace with Healthy foods which do not promote reactions What Helps Probiotics Omega-3 Optimize Prebiotics Vitamins A and D Nutritional status Enzymes Zinc GI flora, function, enzymes, absorption Demulscents Glutamine Sulfation, methylation, detoxification SPECIAL DIETS SPECIAL DIETS . Artificial sweeteners, preservatives, colors, flavors . High fructose corn syrup, agave . Sodas: diet and regular . Hydrogenated oils / trans fats / margarine . Refined grains and processed foods . Sugar . Caffeine . Deep fried foods . Craved foods . Food reactions 2 If it does not grow……do not eat it! FOOD ARTIFICIAL ADDITIVES, PRESERVATIVES Nutrient -Dense, Eco-Friendly Good Fats and Oils American Academy of Pediatrics Acknowledgement • Pasture-fed, grass-fed animals • Extra virgin olive oil • Eggs, seafood, meat, poultry • Butter, animal fats • Meta analysis of 15 trials concluded that a wide • Beans, nuts, seeds • Coconut oil variety of preservatives in the foods commonly • Homemade bone broths • Expeller pressed oils consumed by children, can result in neurobehavioral effects, including ADHD, and some children may be • Vegetables and fruits Natural Sweeteners (limit) more sensitive. • Fermented foods, beverages • Honey, maple syrup • Whole ancient grains • Natural juices • “A preservative-free, food coloring-free diet is a (soaked, sprouted, fermented) • Stevia reasonable intervention.” • Celtic sea salt Resources McCann et al. Lancet. 2007:370)9598):1560-1567 • Filtered water Nourishing Traditions by Sally Fallon ADHD and Food Additives Revisited Schonwald AAP Grand Rounds.2008; • Raw vegetable juices Weston A. Price Foundation ASD DIET OPTIONS DESCRIPTION GFCFSF No GLUTEN: wheat, rye, barley, spelt, No: Gluten, Casein, Soy kamut, oats; MILK casein; Soy PST Low Phenol Diet Avoid high salicylate, phenolic foods. Low Saliclyate/Feingold/Failsafe No artificial ingredients SCD Specific Carbohydrate Diet Restricts carbos to: fruit, non-starch GAPS vegetables and honey. No double Gut and Psychology Syndrome sugars: lactose, maltose, sucrose. BED Body Ecology Diet Anti-yeast diet. No sugar. Use of Anti-yeast fermented foods. Food combining. LOD Low Oxalate Diet Avoid: nuts, beans, greens, some grains and fruits. Worse w/ dysbiosis. Basic Healthy Diet General healthy diet with good protein Nourishing Traditions (Fallon) and nutrient dense foods. FODMAP Avoidance Diet Avoid: Fermentable Oligosaccharides, Disaccharides, Monosaccharides, And Polyols (sugar alcohols) Rotation Diet Based on food families + 4 day rotation. Julie Matthews DIET UNDERLYING PROBLEMS AND SYMPTOMS GFCF DPPIV deficiency >>opioids from gluten, casein (soy proteins). GFCFSF Cravings for gluten, milk/casein, soy. Poor focus, eye contact. Low Phenol Impaired phenol sulfotransferase (PST) and impaired sulfation Salicylate PST metabolizes phenols, participates in brain neuron firing. Feingold Artificial additives; apples, berries, citrus, grapes, tomatoes. Failsafe Red cheeks, ears. Addiction to sources. Silly, aggressive. SCD Disaccharidase deficiency leads to inability to digest double GAPS sugars (lactose, sucrose, maltose, isomaltose) GI symptoms, yeast overgrowth. Grains, beans, starch reactions. BED Underlying bowel dysbiosis due to insufficient good flora and Anti-Yeast the presence of pathogens. Yeast overgrowth. Worse w/ sugars, starches. Fatigue, poor concentration. LOD Bowel dysbiosis: insufficient flora for binding oxalates in gut. Low Deficiencies: B6 & magnesium lead to increased oxalates. Oxalate Pain especially after oxalate foods. Inflammation, sandy stools. FODMAP Problems: lactose, fructose, fructans, galactans, sugar alcohols. Avoidance IBS: maldigestion, gas, bloating, burping, constipation/diarrhea. Rotation For multiple food reactions rendering avoidance too difficult. Julie Matthews Dana Laake 3 SPECIAL DIETS GFCFSF WHAT IT IS No Glutens: wheat, oat, barley, rye, spelt, kamut No milk products / milk casein (protein) No soy: edamame, miso, natto, tamari, tempeh, tofu WHEN TO USE IT Gluten and milk cravings Silly, OCD, self-injury GI: constipation, diarrhea High pain tolerance Poor focus and eye contact Sensory, stims WHAT IT DOES Eliminates opioid source foods (gluten, casein, soy) Improves: focus, attention, eye contact, behavior Reduces: stims, cravings, picky appetite, GI issues ANIMAL SOURCE SATURATED Vegetables Seafood UNSATURATED Fruits Meats Monounsaturated Grains No gluten Poultry Omega-9 olive, avocado, almond Beans No soy Eggs Nuts No milk sources Polyunsaturated Essential Fatty Acids Seeds PLANT SOURCE Omega-3 Beans No soy fish, beans, nuts, seeds Nuts Omega-6 Seeds vegetables + their oils CAN RESULT IN RESIDUES OF Amino Acids AMINO ACID CHAINS CALLED PEPTIDES Can be 20,000 amino acids long If the digestive barrier is healthy, PEPTIDES are ► Too large to be absorbed and ► Will not cross into the blood stream If the gut barrier is “leaky” - PEPTIDES can ► Be absorbed into the blood separate amino acids ► Stimulate an immune reaction …from each other ► Cross into the brain Karyn Seroussi ► Act as false neurotransmitters 4 When the gut mucosal barrier is too permeable - it allows large molecules to cross into circulation …like holes in a window screen ….allow flies in the room DPP IV FUNCTION DIPEPTIDYL PEPTIDASE-IV Increase directly related to opioid food-sources Can be absorbed via the “leaky” gut barrier, and From poor digestion of specific proteins Can cross the blood brain barrier SINGLE Are measureable in urine, CSF, breast milk, blood OPIOID AMINO PEPTIDES DPP-IV ACIDS GLUTEN opioid peptides are Gliadorphin ENZYME tyr – pro – gln –pro –gln –pro –phe GLIADORPHIN There are no problems if any (From Gluten) of the following are true: BOVINE CASEIN opioid peptides are Casomorphin CASOMORPHIN ) (From Casein)) ..No opioid sources (gluten, casein) [Bovine Beta-Casomorphin 7 BCM7] ..Opioids are well digested tyr – pro – phe –pro –gly –pro –ile ..Gut barrier is healthy – not leaky DPP IV FUNCTION DIPEPTIDYL PEPTIDASE IV Are.. • Hallucinogenic • Addicting SINGLE OPIOID AMINO Can cause… PEPTIDES • Silly, spacey behavior DPP-IV ACIDS • Inattention, mood changes ENZYME • Aggression, self-injury •Stims Opioids enter the circulation GLIADORPHIN • Poor eye contact (From Gluten) ..if they are not digested CASOMORPHIN • High pain tolerance ..and the gut is leaky ) (From Casein)) • Addictions to glutens and milk products Opioids cross into the brain • Picky appetite and alter function and behavior 5 Differences A1 “Bad” A2 “Good” Position 67 Histidine Proline BCM7 Opioids Yes No Cow (Bovine) Holstein Brown Swiss Jersey, Milk Sources Guernsey, Asian, African Other Sources Goat Sheep Food sources must be consumed Buffalo Human (gluten, casein, soy) Diabetes CVD Possibly linked Low / no link DPP-IV enzymes must be faulty . Gene mutation changed A2 to A1 milk. Position 67 changed from proline in A2 to histidine in A1. The gut must be leaky . Human milk is best - if the nursing mother avoids animal milk. Avoid animal milk initially, later introducing safer A2 milks. If milk is tolerated, use milk only from pasture-fed animals. Cjeslinska A et al. Int J Food Sci Nutr. 2012 Jun;63(4):426-30. Kaminski S et al. J Appl Genet. 2007;48(3):189-98 Woodford K and Cowan T. Devil n the Milk, 2009. HYPOTHESIS OR FACT? In the GI tract, the BCM7 casomorphin opioids Food source opiate-like endorphins have been: have a positive beneficial effect on … . Identified in urine, CSF, breast milk, and blood . GI growth and development . Linked to: . Motility Autism . Absorption functions Postpartum depression . Secretions Infant SIDS . Immune function Schizophrenia . Dysbiosis Behavior and attention problems Changes in brain function The problems occur when the opioids are K Reichelt, MD www.gluten-free.org/reichelt.html absorbed through a damaged “leaky” gut Whiteley and Shattock Expert Opin Ther Targets 6(2): 175. 2002. Richard Deth, PhD. Int Soc for Autism Res, May 2010. WHEAT-FREE IS NOT GLUTEN-FREE CLINICAL PEARLS ON GFCFSF GLUTEN GRAINS HIDDEN SOURCES Negative tests for gluten and casein are NOT Wheat Hydrolyzed Plant Proteins proof that gluten and milk are tolerated Rye Hydrolyzed Vegetable Protein Trial avoidance is the best test. Barley Artificial flavors and coloring Triticale Dextrin For Celiac: testing includes blood panel, small intestine biopsy, and the gene test. Spelt Malt “ Absolute avoidance is the solution Kamut Citric acid right now. The future is optimistic.”* Semolina MSG Groats Soy sauces (most) * Alessio Fasano. Surprises from Celiac Disease Scientific American: Aug 2009 (54 – 61). Oats (w/ gluten) Playdoh 6 WHEAT-FREE IS NOT GLUTEN-FREE FOR 1 C OF WHEAT AMOUNT QUALITIES Rice Montina Water chestnut THICKENERS Buckwheat flour 7/8 C Strong flavor, light is best Millet Sorghum Jerus. artichoke Agar Corn flour 1 C Light, corn taste Quinoa Tapioca Nut flours Arrowroot Cornmeal/starch