ADINSTRUMENTS making science easier Data acquisition and analysis Isolated tissue - Neurophysiology - Organ bath Intracellular For all aspects of physiological research What researchers are saying about PowerLab Research Systems: software is powerful, easy to use… versatile functions… we have saved a lot of time and labor… record useful data immediately… intuitive features… they’re very reliable “I became interested in ADInstruments after seeing the products shown at the Society for Neurosciences meeting. I love this company and their products. As an investigator in the neurosciences, I deal with many different vendors and many different kinds of equipment and also experience the whole gamut of product quality and customer service. My recent purchase of a PowerLab and LabChart software from ADInstruments stands out as one of the best experiences I have had buying a new product.” Associate Professor Ken Catania, Vanderbilt University, Tennessee, USA “My research group are interested in both basic, pathophysiologically relevant research and clinical experimental research. To combine both is somewhat difficult, with an emerging need for advanced technologies. The PowerLab system has provided us with an affordable, top-technological means to detect, accurately record and analyze biomedical signals. We have studied a number of tissue types, involving smooth muscle and mucosa, together with dedicated ECG for detecting autonomic neuropathy in a number of conditions.” Piero Portincasa, MD, PhD, University of Bari Medical School, Bari, Italy “In the MRI laboratory at Hoffmann-La Roche, PowerLab has been used since 1999. PowerLab is a central technology platform within our laboratory that performs investigations on an average of 1200 animals per year. During MRI scans the physiological state of each animal is monitored, recorded and archived. With the PowerLab system, ADInstruments has created a physiological monitoring system that stands out because of its reliability and ease of use.” Stephanie Schöppenthau, Hoffmann-La Roche Ltd “PowerLabs are very easy to use. They’re intuitive, they’re simple. Because they have no moving parts and no mechanical systems, they’re very robust, they’re very reliable.” Dr Michael Shattock, Rayne Institute, St Thomas’ Hospital, UK “We have been using the ADInstruments PowerLab data acquisition systems, in combination with Millar PVAN Ultra and Transonic Flowmeter, in cardiovascular physiology and pharmacology since our lab was established. ADInstruments software is powerful, easy to use and is regularly updated.” Dr. Rongli Zhang, The Institute of Molecular Medicine, Peking University, China “I have been using an eight-channel PowerLab for more than 3 years along with Millar Mikro-Tip catheters for invasive blood pressure monitoring in rodent models. It has helped me immensely in pursuing my doctoral study on diabetic cardiomyopathy. The ADInstruments software is very user friendly and easy to use even for a novice user. With customizable add-on modules like Blood Pressure and ECG Analysis it makes life science research quite easy for us. It would be my pleasure to continue using the PowerLab in my future experiments and I will certainly recommend the same to my colleagues and friends.” Sandeep Kumar, National Centre for Cell Science, India “I like that PowerLab allows me to use all of my existing amplifiers and transducers. The intuitive interface makes life easy. I like to change gains and display settings on the fly, something the competitor’s system does not allow.” Dr. Jerrel L. Wilkens, University of Calgary, Canada About ADInstruments Established in 1988, ADInstruments is a market-leading provider of computer-based data acquisition and analysis systems for life science. Our customers include internationally- recognized research hospitals, pharmaceuticals, biotechnology companies, contract research organizations, research institutes and 100% of the Quacquarelli Symonds Top 100 Life Sciences and Biomedical Universities in the World (2010). Our success comes The ADInstruments Advantage from providing life Proven track record with installations in thousands of research institutes, science researchers universities, hospital and commercial laboratories around the world. a data acquisition Power and flexibility to be used in a variety of life science applications. and analysis solution Start with a PowerLab system and simply add an appropriate amplifier, that is user friendly, instrument and transducer. Quality and reliability are synonymous with ADInstruments products. ensures data They are manufactured under a quality system certified by an accredited body integrity, is versatile, as complying with ISO 9001:2008. The latest range of research PowerLab and accelerates the systems and signal conditioners are covered by a 5-year warranty to provide research process. peace of mind. Data integrity is paramount. Our PowerLab data acquisition systems are calibrated and tested to deliver data you can trust. GLP and 21 CFR Part 11 compliance is facilitated when a PowerLab system is used with the GLP Module and GLP Server software. Together they provide the required user interface, audit trail and signing components for non-repudiation of data. Being the industry leader for data acquisition is something we’re proud of. With 24 years of design and manufacturing experience, more than 38 000 installations worldwide, over 10 000 research papers we have referenced from research journals, and citations in Google Scholar exceeding 55 000, it’s easy to see why our systems are the preferred choice for life science research all over the globe. Intuitive and powerful software allows researchers to concentrate on the science. With no programming required, the software is mastered quickly and provides comprehensive recording, display and analysis features. Excellence in customer training and support is what we are known for. Our staff includes Scientists, Programmers and Engineers that understand your research needs. In addition, with eleven ADInstruments offices and over forty distributors, we provide a truly global support network. ADInstruments complete research systems provide solutions for Isolated Heart, Isolated Tissue, Blood Pressure Analysis, ECG Analysis, Non- Invasive Blood Pressure, Ventricular Volume, Ventricular Pressure, Blood Flow, Nerve Activity, Cardiac Output, Biopotential, Blood Pressure and SNA Telemetry, Extracellular and Intracellular Recording. Complete research systems include equipment from Gold Standard manufacturers such as Millar Instruments, DMT and Transonic Systems. 1 Contents Introducing ADInstruments Systems 4 A brief description of ADInstruments hardware and software PowerLab in Research 8 Applications, hardware configurations and software features for cardiovascular, respiratory, sleep, exercise and neurophysiology research Mouse and Rat Applications 8 Blood, Atrial and Ventricular Pressure 10 Telemetry 14 ECG and Heart Rate Variability 16 Blood Flow, Cardiac Output and Oximetry 18 Respiratory and Airway 20 Exercise Physiology 22 Electrophysiology 24 Sleep 26 Psychophysiology 28 Isolated Tissue 32 Isolated Perfused Hearts 36 LabChart Software 40 Overview of acquisition, display and analysis features including LabChart Extensions and LabChart Modules. ADInstruments Research Software Overview 40 Key LabChart Features 42 LabChart 46 LabChart Extensions 60 LabChart Reader 61 LabChart Pro and LabChart Modules 62 LabChart Specifications 75 GLP Client & Server 76 2 Data acquisition and analysis ADInstruments Hardware 78 Configured Research Systems and a wide range of Signal Conditioners, Instruments, Transducers and Accessories PowerLab Data Acquisition Systems 78 Research Systems 80 Signal Conditioners 96 Instruments 106 Transducers and Accessories 122 Biochemistry 122 Biopotential 124 Biopotential Consumables 127 Galvanic Skin Response 128 Blood and Fluid Flow 128 Pulse Oximetry 129 Cardiac Output 130 Force and Displacement 130 Heart Sounds 131 Invasive Blood Pressure 132 Langendorff 135 Neurophysiology 136 Noninvasive Blood Pressure 140 Pulse and Plethysmography 141 Respiration 142 Telemetry 144 Wireless Neural Recordings 146 Temperature 146 Organ Bath Stimulating Electrodes 148 Event Markers and Headphones 149 Stimulator Accessories 150 Psychophysiology 151 Product List 152 Index of products PowerLab in Education 156 Information on PowerLab Systems and software in life science teaching 3 introducing ADInstruments systems The core of our product range is the PowerLab® data acquisition unit. When PowerLab hardware is combined with ADInstruments software, researchers have a powerful and versatile data acquisition and analysis system at their command. PowerLab systems provide the full utility of a multi-channel, real-time chart recorder, polygraph, XY plotter, digital voltmeter and storage oscilloscope with the benefits of easy data handling, remarkable resolution, variable sampling speeds and powerful analysis options. ADInstruments extends the use of PowerLab systems with a range of complete solutions for specific applications. Our complete research systems typically include ADInstruments signal conditioners, as well as selected specialized instruments, transducers and accessories from leading manufacturers. ADInstruments Hardware PowerLab 35 Series Signal Conditioners The PowerLab 35 Series units are available in four, eight ADInstruments signal conditioners (preamplifiers) connect and sixteen channels and provide continuous acquisition with PowerLab hardware to acquire the best signal