Endocrine Abstracts November 2016 Volume 44 ISSN 1479-6848 (online) Society for Endocrinology BES 2016 7–9 November 2016, Brighton, UK published by Online version available at bioscientifica www.endocrine-abstracts.org Volume 44 Endocrine Abstracts November 2016 Society for Endocrinology BES 2016 7–9 November, The Brighton Centre Brighton, UK EDITORS The abstracts submitted were marked by the Abstract Marking panel selected by the Programme Committee Programme Committee S Pearce (Chair of the Programme Committee) G Lavery (Programme Co-ordinator) R Semple (Programme Co-ordinator) Members R Andrew N Gittoes S Miczuk E Crowne K Hardy S Pearce E Davies P King L Shepherd M Druce A Logan A Toogood W Farrell C McCardle Co-opted members H Christian V Smith (Birmingham) H Simpson Abstract Marking Panel James Ahlquist Julian Davis Brian Keevil Salman Razvi Ramzi Ajjan Colin Dayan Nikki Kieffer Martin Read Ruth Andrew Miguel DeBono Marta Korbonits Aled Rees Rob Andrews Waljit Dhillo Nils Krone Philippa Saunders Weibke Arlt Will Drake Gareth Lavery Peter Selby Mo Aye Colin Duncan Graham Leese Lisa Shepherd Simon Aylwin William Farrell Jacques Lenders Helen Simpson John Ayuk Rob Fowkes Andy Levy Vicki Smith Tom Barber Jayne Franklyn Miles Levy Roland Stimson Julian Barth Bill Fraser Stafford Lightman Abd Tahrani Andy Bates William Fraser Craig A McArdle Tricia Tan Kristien Boelaert Marie Freel Phil McTernan Christina Thirlwell Pierre Bouloux Neil Gittoes Daniel Morganstein Tony Toft Paul Carroll Helena Gleeson Damian Morris Jeremy Tomlinson Karen Chapman Mark Gurnell Kevin Murphy Mark Vanderpump Krishna Chatterjee Fadil Hannan Rob Murray Gwen Wark Tim Cheetham Pippa Hanson John Newell-Price Tony Weetman Juliet Compston Steve Hillier Simon Pearce Melissa Westwood Sue Cox Megan Holmes Colin Perry Anna Crown Andy James Pat Pickett Eleanor Davies Niki Karavitaki Richard Quinton Society for Endocrinology BES 2016 Corporate supporters The Society for Endocrinology would like to thank its Corporate Supporters for their generous financial assistance. Platinum Supporters Bioscientifica Ipsen Ltd Gold Supporters Internis Viropharma Silver Supporters HRA Pharma Lilly Novartis Sandoz Society for Endocrinology 22 Apex Court Tel: +44 (0) 1454 642200 Woodlands Fax: +44 (0) 1454 642220 Bradley Stoke E-mail: [email protected] Bristol BS32 4JT, UK Website: http://www.endocrinology.org Conference Secretariat Bioscientifica Ltd Contact: Claire Arrigoni/Harriet Edwards Euro House, 22 Apex Court Tel: +44 (0)1454 642240 Woodlands Fax: +44 (0)1454 642222 Bradley Stoke E-mail: conferences@bioscientifica.com Bristol BS32 4JT, UK Website: http://www.bioscientifica.com Endocrine Abstracts (2016) Vol 44 Society for Endocrinology BES 2016 CONTENTS Society for Endocrinology BES 2016 PLENARY LECTURES Society for Endocrinology Medal Lecture . .......................................... PL1 Society for Endocrinology International Medal Lecture . PL2 Society for Endocrinology Starling Medal Lecture . PL3 Society for Endocrinology Dale Medal Lecture . PL4 Society for Endocrinology Jubilee Medal Lecture . PL5 Society for Endocrinology European Medal Lecture . PL6 Society for Endocrinology Transatlantic Medal Lecture . PL7 British Thyroid Association Pitt-Rivers Lecture . PL8 Clinical Endocrinology Trust Visiting Professor Lecture . PL9 Clinical Endocrinology Trust Lecture . ..........................................PL10 SOCIETY FOR ENDOCINOLOGY JOURNAL AWARDS Society for Endocrinology Journal Award–Journal of Molecular Endocrinology ....................... JA1 Society for Endocrinology Journal Award–Journal of Endocrinology ............................. JA2 Society for Endocrinology Journal Award–Endocrine-Related Cancer ............................. JA3 Society for Endocrinology Journal Award–Endocrine Connections .............................. JA4 Society for Endocrinology Journal Award–Clinical Endocrinology .............................. JA5 SYMPOSIA Challenges in pituitary disease . ...................................... S1.1–S1.3 Grappling with the future of anti-inflammatory steroids . S2.1–S2.3 Osteoporosis: translating the new bone biology (Suported by Journal of Endocrinology) . S3.1–S3.3 Advances in the genetic understanding of endocrine disease . S4.1–S4.3 New frontiers for Vitamin D . ...................................... S5.1–S5.3 Why endocrinologists should pay attention to gut feelings (Supported by Endocrine Connections) . S6.1–S6.3 Hormones through the ages . ...................................... S7.1–S7.3 Thyroid hormone: the journey from cell surface to action (Suported by Journal of Molecular Endocrinology) . S8.1–S8.3 Exposing the sins of our fathers (and mothers) . S9.1–S9.3 Clinical thyroidology update . ..................................... S10.1–S10.3 Diabetes mellitus–it’s all about the beta cell, stupid! (Supported by Journal of Endocrinology) . S11.1–S11.3 Novel approaches to endocrine neoplasia (Supported by Endocrine-Related Cancer) . S12.1–S12.3 SPECIAL WORKSHOPS AND SESSIONS Applied Physiology Workshop: Endocrinology on safari: using comparative biology to unravel the complexities of endocrine physiology . ..................................APW1.1–APW1.3 Early Career Symposium: Launching your career whatever it may be . EC1.1–EC1.5 Nurse session 1: Preparing for endocrine pregnancies . N1.1–N1.3 Nurse session 2: Male fertility . ...................................... N2.1–N2.3 Senior Endocrinologists’ Session . ..................................... SE1.1–SE1.4 CLINICAL MANAGEMENT WORKSHOPS Workshop 1: Endocrinology at the edge of the reference range (Supported by Endocrinology, Diabetes & Metabolism Case Reports) . CMW1.1–CMW1.3 Workshop 2: Adrenal insufficiency and CAH ..................................CMW2.1–CMW2.3 Workshop 3: How do I... ............................................CMW3.1–CMW3.6 Workshop 4: How do I manage...(Supported by Endocrinology, Diabetes & Metabolism Case Reports) . CMW4.1–CMW4.6 Endocrine Abstracts (2016) Vol 44 Society for Endocrinology BES 2016 MEET THE EXPERT SESSIONS Extracellular vesicles in health and disease .......................................... MTE1 Society for Endocrinology guidance on the late endocrine effects of cancer treatment . MTE2 Sport–how to support endocrine patients in sport from recreation to Olympics . MTE3 Real-time metabolomics in clinical settings . MTE4 Nutritional support post bariatric surgery .......................................... MTE5 Endocrine disruptors–fact or fiction? . .......................................... MTE6 A Year in Thyroid . .......................................... MTE7 The adolescent with DSD . .......................................... MTE8 Illuminating the islets . .......................................... MTE9 FUTURES Futures 1: My future career in endocrinology? . FUT1.1–FUT1.3 Futures 2: Mapping your route through the Research Funding maze . FUT2.1–FUT2.3 ORAL COMMUNICATIONS Early Career Oral Communications . ......................................OC1.1–OC1.6 Neuroendocrinology and Reproduction . ......................................OC2.1–OC2.6 Thyroid and Neoplasia . ......................................OC3.1–OC3.6 Adrenal and Steroids . ......................................OC4.1–OC4.6 Diabetes Mellitus and Metabolism . ......................................OC5.1–OC5.6 Pregnancy and Reproductive Health . ......................................OC6.1–OC6.6 POSTER PRESENTATIONS Adrenal and Steroids . .........................................P1–P41 Bone and Calcium . ........................................ P42–P61 Clinical biochemistry . ........................................ P62–P89 Diabetes and Cardiovascular . ....................................... P90–P119 Neoplasia, cancer and late effects . ...................................... P120–P137 Neuroendocrinology and pituitary . ...................................... P138–P171 Nursing Practice . ...................................... P172–P173 Obesity and Metabolism . ...................................... P174–P199 Reproduction ...................................................... P200–P232 Thyroid . ...................................................... P233–P258 ePOSTER PRESENTATIONS ..............................................EP1–EP116 FEATURED CLINICAL CASES Featured Clinical Cases . ....................................... CC1–CC10 INDEX OF AUTHORS Society for Endocrinology BES 2016 Plenary Lectures Endocrine Abstracts (2016) Vol 44 Society for Endocrinology BES 2016 Society for Endocrinology Medal Lecture availability can trigger sensors, such as the protein deacetylase sirtuin enzymes, to adjust cellular and tissue physiology in response to changes in nutrient availability PL1 and energy demand. These signalling processes consume NADC and release Understanding estrogen receptor gene regulation in breast cancer nicotinamide (Nam), necessitating constant replenishment via enzyme mediated Jason Carroll recycling of Nam to NADC. Importantly Vitamin B3, comprising a family of University of Cambridge, Cambridge, UK. preformed NADC precursors, can be salvaged by cells to also augment intracellular NADC availability. The combined pathways contributing to dynamic changes in NADC homeostasis can also be regulated by multiple Estrogen Receptor (ER) is the defining feature of luminal breast cancers, where is systems such as circadian clock, hormones and nutritional status. Given that functions as a transcription factor. ER requires associated proteins to interact with NADC homeostasis is vulnerable