Update February 1 - February 7, 2021, Dr. Peter J. Lansberg MD, PhD Weekly COVID-19 Literature Update will keep you up-to-date with all recent PubMed publications categorized by relevant topics COVID-19 publications - Week 05 2021 1328 Publications PubMed based Covid-19 weekly literature update For those interested in receiving weekly updates click here For questions and requests for topics to add send an e-mail [email protected] Reliable on-line resources for Covid 19 WHO Cochrane Daily dashbord BMJ Country Guidance The Lancet Travel restriction New England Journal of Medicine Covid Counter JAMA Covid forcasts Cell CDC Science AHA Oxford Universtiy Press ESC Cambridge Univeristy Press EMEA Springer Nature Evidence EPPI Elsevier Wikipedia Wiley Cardionerds - COVID-19 PLOS Genomic epidemiology LitCovid NIH-NLM Oxygenation Ventilation toolkit SSRN (Pre-prints) German (ICU) bed capacity COVID reference (Steinhauser Verlag) COVID-19 Projections tracker Retracted papers AAN - Neurology resources COVID-19 risk tools - Apps COVID-19 resources (Harvard) Web app for SARS-CoV2 mutations COVID-19 resources (McMasters) COVID-19 resources (NHLBI) COVID-19 resources (MEDSCAPE) COVID-19 Diabetes (JDRF) COVID-19 TELEMEDICINE (BMJ) Global Causes of death (Johns Hopkins) COVID-19 calculators (Medscap) Guidelines NICE Guidelines Covid-19 Korean CDC Covid-19 guidelines Flattening the curve - Korea IDSA COVID-19 Guidelines Airway Management Clinical Practice Guidelines (SIAARTI/EAMS, 2020) ESICM Ventilation Guidelines Performing Procedures on Patients With Known or Suspected COVID-19 (ASA, 2020) OSHA Guidance on Preparing the Workplace for COVID-19 (2020) Policy for Sterilizers, Disinfectant Devices, and Air Purifiers (FDA, 2020) Breast Cancer Patient Triage Guidelines (CPBCC, 2020) clinical guidance for adult Belgian patients with suspected or confirmed COVID-19 National Covid-19 Testing Action Plan (Rockefeller Foundation) ASE issues Echo-cardiography guidance Trials & Registries CAPACITY European registry COVID 19 patients WHO launches global megatrial FDA launches Convalescent plasma trial Lets Beat Covid-19 Survey to help plan hospital services COVID IBD registry Google mobility reports per country COVID 19 World's largest trial of potential coronavirus treatments rolled out across the UK Pregnancy Registry (US) ICNARC report on COVID-19 in critical care - NHS April 24 COVID-19 Human Genetics - Biobanks COVID19 settings of transmission database COVID-19 prevention network Covid-Plex trial - (plasma exchange & convalescent plasma trial) The Covid-Plex trial is an investigator initiated, multicenter, parallel-group, open-label randomized clinical trial aiming to randomize patients with severe COVID-19 to standard care or standard care plus plasmapheresis and convalescent plasma. If you are interested to participate Please contact Wladimir Szpirt, Nicholas Carlson Anders, or Perner Bo Feldt-Rasmussen. Depts. Of Intensive Care Therapy and Nephrology, Copenhagen University Hospital Rigshospitalet, Denmark Covid-Plex trial Mainstream Media New York Times - Corona update How Merck, a Vaccine Titan, Lost the Covid Race WHO Panel Recommends AstraZeneca Vaccine Despite Variant Concerns U.K. residents may not be allowed to travel abroad until all adults are vaccinated. Half of U.S. Coronavirus Deaths Have Come Since Nov. 1 Could a Single Vaccine Work Against All Coronaviruses? People With Dementia Are Twice as Likely to Get Covid, Huge Study Finds Coronavirus Variants and Mutations A Few Covid Vaccine Recipients Developed a Rare Blood Disorder Coronavirus Vaccine Tracker Coronavirus Drug and Treatment Tracker Washington Post - Corona update France is seeing a baby bust nine months after its first covid lockdown No quarantine needed who have received both shots of coronavirus vaccine, Masks should fit better or be doubled up to protect against coronavirus variants, U.K. coronavirus restrictions to include hotel quarantines, threats of fines and prison Denmark says it has U.K. coronavirus variant under control, for now CDC weighs coronavirus testing requirement for flights, industry voices opposition Variants mean the coronavirus is here to stay — but perhaps as a lesser threat What we know about how the coronavirus started, and why it matters ‘Coronaphobia’: Covid anxiety has a name. Here’s how to cope. Guardian - Corona update ‘It’s impossible to pay’: the UK residents trapped overseas by quarantine rules Coronavirus live: international travel 'biggest factor in death rate' US could have averted 40% of Covid deaths, says panel examining Trump's policies Before you compare the Covid vaccines, here are five things to know Vaccination passports are nothing new – and the sooner we have them Key Articles 1. Efficacy of convalescent plasma therapy for COVID-19: A systematic review and meta-analysis. J. Clin. Apher. 2021; Vegivinti CTR, Pederson JM, Saravu K et al. http://www.ncbi.nlm.nih.gov/pubmed/?term=33544910 The potential benefit of convalescent plasma therapy in COVID-19 seems self- evident based on a long experience of using this approach in other infectious diseases. This meta-analysis screened 859 (!) studies and identified 15 articles that fit the inclusion criteria. Overall total mortality was significantly reduced, OR: 0.59 (0.44-0.78; P<0.001), but two key RCTs failed to support this. Clinical improvement was favorable in patients treated with convalescent plasma, OR:2.02 (1.54-2.65; P<0.001). No differences in duration of hospital stay were observed, MD=-0.49 (-3.11 to 2.12; P=0.713) 2. Cardiac arrest in COVID-19: characteristics and outcomes of in- and out- of-hospital cardiac arrest. A report from the Swedish Registry for Cardiopulmonary Resuscitation. Eur Heart J 2021; Sultanian P, Lundgren P, Strömsöe A et al. http://www.ncbi.nlm.nih.gov/pubmed/?term=33543259 Patients with COVID-19 infections are at increased risk for (fatal) cardiovascular complications partly because of the pathophysiological driving forces of the SARS-CoV2 viral infection and partly because of avoidance to seek proper medical care. Data from the National Swedish Registry for Cardiopulmonary Resuscitation was used to analyse the impact of COVID-19 on in- and out-of- hospital cardiac arrests. COVID-19 was involved in ≥10% of OHCAs and 16% of IHCAs. The 30-day mortality increased 3.4-fold in OHCA and 2.3-fold in IHCA. 3. COVID-19 Coagulopathy: Current knowledge and guidelines on anticoagulation. Heart Lung 2021; 50:357-360Salabei JK, Fishman TJ, Asnake ZT et al. http://www.ncbi.nlm.nih.gov/pubmed/?term=33524866 Coagulopathies are frequently observed COVID-19 (fatal) complications. This review shares recent insights into the potential etiologies, from direct cytotoxicity, activation of pro-inflammatory molecules, e.g., cytokines, to endothelial cell dysfunction. The authors point out that the observed clinical and laboratory characteristics are distinctly different from sepsis and ARDS associated coagulopathy. Institution specific guidelines for prophylactic anticoagulation are recommended to address the specific needs of the different patient populations cared for. 4. COVID-19-Associated Cytokine Storm Syndrome and Diagnostic Principles: An Old and New Issue. Emerg Microbes Infect 2021:1-30Xi Y. http://www.ncbi.nlm.nih.gov/pubmed/?term=33522893 5. The atherogenic index of plasma as a predictor of mortality in patients with COVID-19. Heart Lung 2021; 50:329-333Turgay Yıldırım Ö, Kaya Ş. http://www.ncbi.nlm.nih.gov/pubmed/?term=33524862 6. Haemostatic and thrombo-embolic complications in pregnant women with COVID-19: a systematic review and critical analysis. BMC Pregnancy Childbirth 2021; 21:108Servante J, Swallow G, Thornton JG et al. http://www.ncbi.nlm.nih.gov/pubmed/?term=33546624 7. Statins in patients with COVID-19: a retrospective cohort study in Iranian COVID-19 patients. Transl Med Commun 2021; 6:3Peymani P, Dehesh T, Aligolighasemabadi F et al. http://www.ncbi.nlm.nih.gov/pubmed/? term=33521322 8. Prevalence of SARS-CoV-2 in children from a cohort of 2192 patients. Monatsschr. Kinderheilkd. 2021; 169:46-51Meyer M, Rübsteck E, Lehmann C et al. 9. High-dose vitamin D versus placebo to prevent complications in COVID- 19 patients: A structured summary of a study protocol for a randomised controlled trial (CARED-TRIAL). Trials 2021; 22:111Mariani J, Tajer C, Antonietti L et al. http://www.ncbi.nlm.nih.gov/pubmed/?term=33522946 10. The Incidence, Prognosis and Laboratory Indicators of Venous Thromboembolism in Hospitalized Patients with COVID-19: A Systematic Review and Meta-analysis. J Vasc Surg Venous Lymphat Disord 2021; Liu Y, Cai J, Wang C et al. http://www.ncbi.nlm.nih.gov/pubmed/?term=33529719 11. Thrombosis and Coagulopathy in COVID-19: Current Understanding and Implications for Antithrombotic Treatment in Patients Treated With Percutaneous Coronary Intervention. Front Cardiovasc Med 2020; 7:599334Liu H, Wang Z, Sun H et al. http://www.ncbi.nlm.nih.gov/pubmed/? term=33537347 12. Beneficial Effect of Statins in COVID-19-Related Outcomes: A National Population-Based Cohort Study. Arterioscler. Thromb. Vasc. Biol. 2021:Atvbaha120315551Lee HY, Ahn J, Park J et al. http://www.ncbi.nlm.nih.gov/pubmed/?term=33535790 13. Cardiac arrest and COVID-19: inflammation, angiotensin-converting enzyme 2, and the destabilization of non-significant coronary artery disease-a case report. Eur Heart J Case Rep 2021; 5:ytaa475Colombier S, Mahendiran T, Niclauss L, Kirsch M. http://www.ncbi.nlm.nih.gov/pubmed/? term=33542974 14. Native High-Density Lipoproteins (HDL) with Higher Paraoxonase Exerts a Potent Antiviral Effect against SARS-CoV-2 (COVID-19), While Glycated HDL Lost the Antiviral Activity. Antioxidants (Basel) 2021; 10Cho KH, Kim JR, Lee IC, Kwon HJ. http://www.ncbi.nlm.nih.gov/pubmed/?term=33535459 15. Steroid harms if given early in COVID-19 viraemia. BMJ Case Rep. 2021; 14Arora K, Panda PK. http://www.ncbi.nlm.nih.gov/pubmed/?term=33541971 Basic Science (68 articles) 1. Regeneration Profiles of Olfactory Epithelium after SARS-CoV-2 Infection in Golden Syrian Hamsters. ACS Chem Neurosci 2021; Urata S, Maruyama J, Kishimoto-Urata M et al. http://www.ncbi.nlm.nih.gov/pubmed/?term=33522795 2.