José Luis Pires SARS-Cov-2 Report 12 June 2020 Contents SARS-Cov-2 ➢ Confirmed cases by Country ➢ Deaths by Country ➢ Total confirmed Covid-19 cases and deaths per million people ➢ Daily new confirmed Covid-19 cases and deaths per million people (new) ➢ Covid-19 Projections – Portugal (new) ➢ Portugal, Lisbon, Loures, Macau, New Jersey, Cork - Cases by day and Total ➢ Reported infections per 1 million people for select countries with over 100 reported cases ➢ New cases vs 7-day average ➢ Cases Curve Simulator ➢ The latest coronavirus updates and developments impacting the global pharmaceutical supply chain June 2020 Confidential Hovione © 2020 2 Coronavirus (SARS-CoV-2 / Covid-19) – Confirmed cases by country Note: Selected Countries, sorted by # of cases US 2,023,347 Brazil 802,828 Russia 510,761 India 297,535 UK 292,860 Spain 242,707 Italy 236,142 France 192,493 Germany 186,691 Turkey 174,023 Canada 99,159 China 84,217 Belgium 59,711 Netherlands 48,458 Sweden 48,288 12 June 2020 5 June 2020 29 May 2020 22 May 2020 15 May 2020 8 May 2020 1 May 2020 24 April 2020 Singapore 39,850 Portugal 35,910 Switzerland 31,044 Argentina 27,373 Ireland 25,238 Philippines 24,175 Israel 18,701 Japan 17,230 Austria 17,034 Denmark 12,235 Korea 12,003 Norway 8,608 Morocco 8,537 Malaysia 8,369 Australia 7,289 Finland 7,064 Hungary 4,053 Last Updated at 12 June 2020, 9:33 AM Luxembourg 4,052 Thailand 3,129 by the Center for Systems Science and Engineering Greece 3,088 at Johns Hopkins University Croatia 2,249 https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6 Estonia 1,970 : Iceland 1,807 Lithuania 1,756 Source Slovenia 1,490 June 2020 Confidential Hovione © 2020 3 0 500,000 1,000,000 1,500,000 2,000,000 2,500,000 Coronavirus (SARS-CoV-2 / Covid-19) – Deaths by Country Note: Selected Countries, sorted by # of cases 120,000 113,820 100,000 80,000 60,000 Last Updated at 12 June 2020, 9:33 AM by the Center for Systems Science and Engineering 40,919 41,364 at Johns Hopkins University 40,000 34,167 29,349 27,136 20,000 8,772 9,636 6,7058,498 8,071 4,763 4,638 6,0634,814 25 1,5041,9377651,7031,036300 922 674 593 277 242 211 118 102 325 555 110 58 183 106 69 10 74 109 0 Source: https://gisanddata.maps.arcgis.com/apps/opsdashboard/index.html#/bda7594740fd40299423467b48e9ecf6 June 2020 Confidential Hovione © 2020 4 Total confirmed Covid-19 cases per million people June 2020 Confidential Hovione © 2020 5 Daily new confirmed Covid-19 cases per million people Portugal ranks as EU country with second highest number of new cases in last 14 days, per million people June 2020 Confidential Hovione © 2020 6 Total confirmed Covid-19 deaths per million people June 2020 Confidential Hovione © 2020 7 Daily new confirmed Covid-19 deaths per million people June 2020 Confidential Hovione © 2020 8 Covid-19 Projections – Portugal - Cases June 2020 Confidential Hovione © 2020 9 Source: https://covid19-projections.com/portugal Covid-19 Projections – Portugal - Deaths June 2020 Confidential Hovione © 2020 10 Source: https://covid19-projections.com/portugal Coronavirus (SARS-CoV-2 / COVID 19) – Portugal - Confirmed cases by day 1600 1516 1400 1200 1035 1000 902 852 808 815 792 783 754 750 800 724 712699 663657 633 638 643 598 603 595 549 540 553 600 515 514 521516 533 472 480 460 446 452 444 421 371 366377382 400 349 350 342 320 331 310 302 295 306 288 285304 297 294 260 264 252271 257 270 235 242 234 227226 228 219 223 219 200 194 181 183 178 175138 187 173 195 192 143 163 152165 200 117 7686 92 98 3457 2 2 2 3 4 8 9 9 21819 0 0 * Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/ * - recalculated numbers June 2020 Confidential Hovione © 2020 11 Coronavirus (SARS-CoV-2 / COVID 19) – Portugal - Total cases by day 40000 120% 36,180 33,969 35,910 35,30635,600 34,69334,885 31,946 34,351 35000 100% 33,26133,592 32,70032,895 30,200 32,20332,500 31,596 100% 31,00731,292 30,47130,62330,788 29,43229,66029,912 30000 28,81029,03629,209 27,91328,13228,31928,583 27,26827,40627,58127,679 26,715 25,70226,182 25,05625,35125,19025,28225,524 80% 24,02724,32224,505 25000 23,39223,864 22,797 21,98222,353 21,379 62% 20,863 20,206 19,685 20000 18,84119,022 60% 18,091 51% 17,448 50%50% 16,58516,934 15,987 45% 15,472 44%43% 44%44% 43% 15000 13,956 13,141 35%35% 30% 12,452 40% 32% 25% 11,27811,730 10,524 30% 29% 9,886 27% 9,034 10000 25% 8,251 22% 20%21% 7,443 18% 5,9626,40816% 15% 5,17015% 20% 4,268 5000 3,544 11%9%9% 11% 2,995 7% 6%7% 6% 6% 5% 2,0602,362 4% 6% 4% 1,2801,600 3%4% 3%4% 3%3%3%2%3% 3% 2% 6427851,020 2% 1% 2%2% 2%1%1%1% 1% 1%1%2%2%2%1%1% 1%1%1%1%1%1%1%1%1%1%1%1%0%1%1%1%1%1%1%1%1%1%1%1%1%1%1%1%1%1%1%1% 0%2 4 6 9 13213039415978112169245331448 0% 0% 0 0% # of cases % increase Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/ June 2020 Confidential Hovione © 2020 12 Coronavirus (SARS-CoV-2 / COVID 19) – Portugal – Hospital: Stable vs ICU 1400 13021284 1253 1227 1243 1211 1200 1208 118011731179117511771187 1172 1200 1146 1099 1095 10751084 1068 10421058 1040 1005995 980968 1000 936 892 874 855856 838 842 818 813 815797805 800 726 709 692680 673657649 628629 627 609608 571 576 550 600 536531 529 513510512 514 440 486 474471 445 418 432428 421414 417415 398 394 400 354 366 276 267270271 245251 245 230240 241226233228 229222228224 206 201203 218208 215213207204 191 188 188 188186182176172 172 156169 164 169 154150 200 139139 126 136 144143134136135127 73 107107114 120112112113 108 115108105 8989 89 103 112 101939284 616171 80787271666566636464 657070 4057 414748 58565858575855 213038 20202635 0 0 0 0 09 130 0 0 0 0 0 0 0 10 9 1817 0 Hospital Stable Hospital ICU Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/ June 2020 Confidential Hovione © 2020 13 Coronavirus (SARS-CoV-2 / COVID 19) – Portugal – Deaths vs Recoveries 25000 22200 2174222002 2052621339 208072099521156 2007920323 189111955219869 1918619409 20000 18637 1809618349 1754917822 15000 10000 75907705 6430643164526452 4636 5000 3822 3013318231983328 249925492549 1505 207622582422 1289 1383 1465 1470151916471671168917121743 14471455147414791485149214971504 1146120112281277132913571389 10891105111411261135114411631175118411901203121812311247126312771302131613301342135613691396141014241436 73576291778582085488090392894897398910071023104310631074 380409435470504535567383599493629519657610687610714610 0 0 0 0 0 0 0 0 0 0 0 01 01 01 02 13 13 23 3 56 125 145 14232233224343604376100431194314043160431874320968246682667529575140311184345196205233266277277347 0 Total Confirmed Deaths Total Confirmed Recoveries Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/ June 2020 Confidential Hovione © 2020 14 Coronavirus (SARS-CoV-2 / COVID 19) Portugal 12June 020 June 2020 Confidential Hovione © 2020 15 Coronavirus (SARS-CoV-2 / COVID 19) – Loures - Confirmed cases by day 60 56 54 52 50 48 43 40 40 37 35 33 33 34 33 32 31 31 31 30 29 29 30 27 27 25 25 23 2323 22 21 21 20 19 18 20 17 17 17 17 15 14 13 12 12 11 11 11 11 10 10 9 9 9 9 9 8 8 8 8 8 8 10 7 7 7 6 5 5 4 4 4 3 3 2 2 2 1 1 0 0 0 0 0 0 0 1.apr 2.apr 3.apr 4.apr 5.apr 6.apr 7.apr 8.apr 9.apr 1.may 2.may 3.may 4.may 5.may 6.may 7.may 8.may 9.may 01.jun 02.jun 03.jun 04.jun 05.jun 06.jun 07.jun 08.jun 09.jun 10.jun 11.jun 12.jun 10.apr 11.apr 12.apr 13.apr 14.apr 15.apr 16.apr 17.apr 18.apr 19.apr 20.apr 21.apr 22.apr 23.apr 24.apr 25.apr 26.apr 27.apr 28.apr 29.apr 30.apr 24.mar 25.mar 26.mar 27.mar 28.mar 29.mar 30.mar 31.mar 10.may 11.may 12.may 13.may 14.may 15.may 16.may 17.may 18.may 19.may 20.may 21.may 22.may 23.may 24.may 25.may 26.may 27.may 28.may 29.may 30.may 31.may Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/ June 2020 Confidential Hovione © 2020 16 Coronavirus (SARS-CoV-2 / COVID 19) – Loures - Total cases by day 1600 120% 1,383 104% 1,352 1400 1,331 1,288 100% 1,172 1,236 1,209 1,191 1200 1,147 1,114 1,089 1,066 982 1,043 1,009 80% 1000 934 894 863 828 802819 800 771 60% 715 678 642656 612 591604 559576 600 536 497505507 40% 453464464 408410420 386393400 400 369 315315315 20% 292292301303304 251257260 17% 17% 17% 221231240 14% 201212 20% 12%13% 13%1797%191196 12% 200 158 3% 8% 8%126130131134138 8% 8% 1011097%117 7% 6% 72 84 5%4%5% 5% 5% 4% 5% 5% 4% 4% 4%5% 4% 57 64 3% 2%3% 3% 4% 2% 3% 4% 2% 2% 2% 3%3%2% 2%3% 2% 4% 3%3%2%2%2%3%2% 2% 3% 2% 24 280%280%28 1% 1% 0% 1%0% 0%0% 2%2% 0% 0% 2%0% 1% 1% 2%2% 2% 0 0% 1.apr 2.apr 3.apr 4.apr 5.apr 6.apr 7.apr 8.apr 9.apr 1.may 2.may 3.may 4.may 5.may 6.may 7.may 8.may 9.may 01.jun 02.jun 03.jun 04.jun 05.jun 06.jun 07.jun 08.jun 09.jun 10.jun 11.jun 12.jun 10.apr 11.apr 12.apr 13.apr 14.apr 15.apr 16.apr 17.apr 18.apr 19.apr 20.apr 21.apr 22.apr 23.apr 24.apr 25.apr 26.apr 27.apr 28.apr 29.apr 30.apr 24.mar 25.mar 26.mar 27.mar 28.mar 29.mar 30.mar 31.mar 10.may 11.may 12.may 13.may 14.may 15.may 16.may 17.may 18.may 19.may 20.may 21.may 22.may 23.may 24.may 25.may 26.may 27.may 28.may 29.may 30.may 31.may # of cases % increase Source: https://covid19.min-saude.pt/ponto-de-situacao-atual-em-portugal/ June 2020 Confidential Hovione © 2020 17 Coronavirus (SARS-CoV-2 / COVID 19) – Lisbon - Confirmed cases by day 250 228 200 150 97 97 100 82 85 75 71 60 60 55 54 54 56 48 48 48 48 50 51 39 41 40 41 41 39 41 353839 40 38 50 34 34 32 36 3634 27 31 283031 31 26 20 1924 23 24 22 24 24 2024 1924 24 19 19 18 16 15 16 13 18 14 12 7 12 11 9 0 5 5 0 0 0 2 5 0 1.apr 2.apr 3.apr 4.apr 5.apr 6.apr 7.apr 8.apr 9.apr 1.may 2.may 3.may 4.may 5.may 6.may 7.may 8.may 9.may 01.jun 02.jun 03.jun 04.jun