CLINICAL THERAPEUTICS/NEW TECHNOLOGY—GLUCOSECATEGORY MONITORING AND SENSING in the assessment and treatment of T1DM. Whether hope is valuable for risk study. Traditional methods to recruit lower income AA women into diabetes prediction models of future HbA1c remains to be determined. self-care interventions may be challenging due to the transient nature of the Supported by: KU Diabetes Institute population and women’s competing life and medical priorities. Finding ways to help women manage these priorities as part of the recruitment process as 2320-PO well as employing non-traditional recruitment methods, such as face-to-face Patterns of Complementary Therapy Use Among Rural Older Adults recruitment in community settings, may yield better recruitment results. With Diabetes RONNY BELL, SARA QUANDT, JOSEPH GRZYWACZ, REBECCA NEIBERG, WEI 2322-PO LANG, THOMAS ARCURY, Winston-Salem, NC The Effect of Diabetes and its Control on Susceptibility to Learned Previous studies on complementary therapy (CT) use among adults with Helplessness in Streptozotocin-Induced Diabetes Rats diabetes have been limited by crude measures of current use across broad YOSHIE GO, HARUKO KITAOKA, TATSUYA FUJIKAWA, Sakai, Japan CT categories, and by a lack of specifi city of CT use for treating diabetes. AIMS: In order to examine the mechanism linking diabetes to depression, Data for the current analysis are drawn from a study of CT use among rural hyper and hypoglycemia are different at risk of affective disorder. METH- African American and white older (age >65) adults in southeastern North ODS: Using the streptzotocin rats, totally 37 rats, were divided into 4 types Carolina. Among the 200 study participants, 71 (35.6%) reported having of glycemic control groups, Group A (good), B (hypo-hyper) ,C (untreated), D been told by a doctor that they have diabetes. Baseline and repeated three- (controls). The bodyweight, the blood glucose concentration and HbA1c were day assessments (n=52) of use of six categories of CTs for treating diabetes measured. And all animals were placed in a learned helplessness paradigm, symptoms were conducted monthly by trained interviewers over a six-month Forced swimming test : the scorer would rate immobility and another action. period. At baseline, the most commonly used CTs included prayer (88.7%), We examined the differences in the length of immobility ( a key marker of food or beverages (50.7%), herbs (11.3%) and home remedies (9.9%). Over- learned helplessness) with the analysis using Tukey-Kramer multiple com- the-counter therapies and CT professionals were used by less than 1% of parison. RESULTS: Glycemic control: Group A had nearly kept smaller change participants. In repeated measures representing 1131 interviews, prayer of blood glucose throughout the day. Group B of blood glucose showed a very was used on 57.2% of days, followed by food or beverages (12.7%), herbs steep fall from 475.8 ± 193.2 (mean ± SD) mg/dl to 42.8 ± 22.6 mg/dl within (3.4%) and home remedies (2.7%). Over half (56.3%) of those using prayer did three hours after the insulin injection. Mean HbA1c of Group C signifi cantly in- so in at least fi ve of the six reporting periods, whereas use of other CTs was creased from 5.9 ± 1.3 to 8.7 ± 4.0 % (p < 0.0001). In A and B group the level of more sporadic. These data show, with the exception of prayer and food and HbA1c decreased from 5.6 ± 1.0 to 3.8 ± 0.6 % and 6.4 ± 1.7 to 3.7 ± 0.5 % re- beverages, fairly limited use of CTs for diabetes treatment among rural older spectively. The bodyweight in A and B groups was not signifi cantly different Therapeutics Clinical Diabetes/ adults, and less consistent use for most CTs except prayer. Further research compared with that in non diabetic control group (P = 0.001, 0.001). Group C PUBLISHED ONLY is needed to more fully understand the motivations and patterns of CT use is signifi cantly low compared with that in Group D (< 0.0001). FST: There were in this population. trends for counts of immobility to be higher in all 3 diabetic groups compared to Group D, especially in Group B, the mean count of immobility is signifi cantly CT Use at Baseline and in Repeated Assessments among Rural Older Adults high compared with Group D (< 0.001). There is no signifi cant difference in with Diabetes the mean counts of swimming. The climbing was signifi cantly low in Group Therapy Baseline Six-Month C compared to Group D (< 0.001). CONCLUSION: These investigations are (N=71) Follow-Up (n=52) thought to be interesting to examine the relationship between diabetes and N, % of Total N, N, depression, and suggested that acute varieties in glycemic control could be % of Days % of Use at the mechanism of susceptibility to affective disorder. Used Least 5 of 6 Months Prayer 63 (88.7%) 531 (57.2%) 27 (56.3%) CLINICAL THERAPEUTICS/NEW TECHNOLOGY— Food or Beverage 36 (50.7%) 119 (12.7%) 2 (7.4%) GLUCOSE MONITORING AND SENSING Over-the-Counter Remedies 1 (1.4%) — — Herbs 8 (11.3%) 32 (3.4%) 1 (14.3%) 2323-PO Assessment of Hematocrit Interference of Blood Glucose Meters in Home Remedies 7 (9.9%) 25 (2.7%) 0 a Comprehensive Laboratory Setting Complementary Health Professionals 3 (4.2%) 3 (0.3%) 0 ANDREAS PFÜTZNER, PETRA B. MUSHOLT, CHRISTINA SCHIPPER, SANJA RAM- Supported by: National Center for Complementary and Alternative Medicine (R01 LJAK, ALEXANDRA BEER, FRANK FLACKE, THOMAS FORST, Mainz, Germany, AT003635) Frankfurt, Germany Primary objective of this study was to investigate the susceptibility of four blood glucose meters to hematocrit (HCT) interference in a laboratory setting. 2321-PO Three different strip lots were used for each of the following devices: BG*Star Recruiting Lower-Income African American Women into a Diabetes and iBG*Star (both Sanofi ), Breeze 2 (Bayer), OneTouch Verio Pro (Lifescan), Medical Nutritional Therapy Intervention and YSI analyzer (reference method). Heparinized blood was manipulated to MALINDA A. BROOKS, STEPHANIA MILLER-HUGHES, Nashville, TN contain 6 different blood glucose levels in a range from 30 mg/dL to 600 mg/dL This research describes the recruitment of lower-income African Ameri- and 9 hematocrit concentrations (20 % to 60 %, in 5 % increments), resulting can (AA) women into a diabetes medical nutritional therapy intervention in 54 individual samples. In order to eliminate disturbing systematic external as part of an academic research institution (ARI)/managed care organiza- factors, all measurements were carried out in triplicate and in parallel within tion (MCO) partnership. The MCO partners mailed out 331 invitation letters 20 min for all meter/strips combinations by 12 experienced investigators after to AA women enrolled in their diabetes management program. The letter confi rmation of a physiological oxygen pressure in each freshly prepared sam- described the ARI-facilitated diabetes medical nutritional therapy interven- ple (468 readings per device&strip lot combination). For the analysis, values at tion and provided an ARI contact number. The ARI partners used a paper 45 % hematocrit were set to 100 %. For benchmarking, maximally observed and electronic tracking system to monitor responses to the invitation letter mean deviations from this value in both directions were added to determine and follow-up communications. One hundred thirty-eight women responded the hematocrit interference factor (HIF). Based on clinical considerations, an to the letter or follow-up calls (25 called the ARI to request additional in- HIF > 10 % was arbitrarily defi ned to present relevant hematocrit interference. formation; the ARI partners contacted 113 by phone after receiving no re- Accuracy was determined by calculating the mean absolute percent devia- sponses to the letter). The ARI partners left voice mails for forty-fi ve women tion from the reference method (MARD). As indicated by HIF/MARD-values of for which no return calls were received. Seventy-three had disconnected 4.6%/4.8% for BG*Star, 3.0%/4.9% for iBG*Star, and 1.7/4.6 % for OneTouch phones or numbers not receiving incoming calls. Eighty-fi ve women had Verio Pro, these devices showed to have a high accuracy at all HCT concentra- no phone number listed in the MCO database. Of the 138 women that re- tions. This was not the case for Breeze 2 (42.6%/15.9%), which showed too sponded to the letter or follow-up calls, 42 were screened by phone, met high reading at low HCT levels and vice versa. In this comprehensive laborato- non-clinical study criteria, and scheduled a clinical in-person screening visit. ry investigation, the technologies of BG*Star, iBG*Star and OneTouch Verio Pro Ninety-six either failed the phone screening or were not interested due to showed to be not affected by hematocrit and to be very accurate in compari- reasons such as family responsibilities and other chronic health conditions. son to the reference method even under these artifi cial laboratory conditions. Of the 42 women that scheduled a clinical in-person screening visit, 28 kept Supported by: sanofi -aventis appointments. Seventeen met all study criteria and were enrolled into the ADA-Funded Research For author disclosure information, see page 797. A585 CLINICAL THERAPEUTICS/NEW TECHNOLOGY—GLUCOSECATEGORY MONITORING AND SENSING 2324-PO 2326-PO Consistent Performance of Dexcom G4 When Calibrated at Different Use of Glucolysis Inhibitors in Blood Drawing Tubes Shall not Pre- Rates-of-Change (ROC) vent Diagnostic Errors ARTURO GARCIA, AARTHI MAHALINGAM, APURV KAMATH, San Diego, CA HECTOR GARCIA-ALCALA, MACARENA FERNANDEZ-MACOUZET, ALEJANDRO Continuous Glucose Monitors (CGM) measure glucose in the interstitial RUIZ-ARGÜELLES, Puebla, Mexico fl uid (IF), but are calibrated with blood glucose (BG) from capillary fi nger- Blood glucose is an important test to identify and evaluate diabetic pa- sticks.