PROGRAM AND ABSTRACTS OF PAPERS JAPANESE ASSOCIATION FOR DENTAL RESEARCH The 68th ANNUAL MEETING November 7-8, 2020 Virtual Meeting CONTENTS Officers of JADR ………………………………………………………………… 4 JADR Timetable …………………………………………………………………… 5 Scientific Program ………………………………………………………………… 7 (Abstracts) Keynote Lecture …………………………………………………………………… 25 Greeting …………………………………………………………………………… 29 Special Lecture …………………………………………………………………… 33 Symposium (I ~III) ………………………………………………………………… 37 Rising Scientist Session …………………………………………………………… 65 Poster Presentation ………………………………………………………………… 73 Author Index ……………………………………………………………………… 119 List of Sponsors …………………………………………………………………… 123 ─ 2 ─ Welcome message Dear Craniofacial and Dental Scientists: In behalf of the organizing committee and as the Chairman of the 68th Annual Meeting of Japanese Association of Dental Research (JADR) 2020, I am delighted to welcome every one of you to this meeting. It is our great honor and pleasure to hold such a prestigious meeting. Although conducting this meeting is very difficult because of the COVID-19 pandemic, we express our gratitude to the president of JADR, Professor Satoshi Imazato, and all of our distinguished guests for their attendance. JADR has contributed to the advancement of basic and clinical research in the dental science field in Japan, in collaboration with the International Association for Dental Research (IADR). We have decided to designate "Beyond Borders: From Dental Research to Future Oral Health" as the main theme of this meeting to expand the basic and clinical research and produce a new translational researc h for spurring evolution in dentistry. We will invite Dr. Pamela Den Besten (from IADR) and Dr. Joo-Cheol Park (from the Korean Division of the IADR (KADR) as Special Lecturers, who will share with us their future outlook in regard to dental science. As for the Keynote, Professor Richard J. Lamont from the University of Louisville will present an interesting lecture concerning the process of dysbiosis in periodontitis. We will also organize three symposiums on this particular topic, entitled "At the front-line: Etiology of periodontitis," "Pathophysiological approach from the oral function to systemic diseases" and "Future is now! Stem cell revolution in hard and soft tissue engineering" from which we reach the frontline of periodontitis, oral function from the pathophysiological viewpoint, and stem cell research. We also organized a symposium on neuroscience for young investigators. Although the meeting will take place online because of the complicated COVID-19 situation, we believe that this meeting will provide an excellent opportunity for all attendees to learn together in the virtual world to evolve dental science through telecommunications beyond the physical distance. The 68th Annual Meeting of Japanese Association for Dental Research Congress President: Kazuyuki Ishihara, D.D.S., Ph.D. Professor Department of Microbiology, Tokyo Dental College ─ 3 ─ OFFICERS OF JAPANESE ASSOCIATION FOR DENTAL RESEARCH President ………………………………………………………………………… S. Imazato President-elect and Vice-president ……………………………………………… S. Nakamura Immediate Past President ……………………………………………………… K. Yamazaki Treasurer ………………………………………………………………………… K. Moriyama Director ………………………………………………………………………… T. Goto Director ………………………………………………………………………… M. Honda Director ………………………………………………………………………… K. Ikebe Director ………………………………………………………………………… K. Ishihara Director ………………………………………………………………………… T. Matsumoto Director ………………………………………………………………………… M. Noda Director ………………………………………………………………………… S. Yamada Director ………………………………………………………………………… A. Yoshihara Auditor ………………………………………………………………………… N. Takahashi Auditor ………………………………………………………………………… T. Takata Chairman, Organizing Committee ……………………………………………… K. Ishihara Secretary-general ……………………………………………………………… Y. Shibukawa ─ 4 ─ JADR Timetable November 7th (Sat.) November 8th (Sun.) Video On-demand distribution / Live streaming November 7 (Sat.) November 8 (Sat.) 9:00 10:00 10:00 ～ 12:00 10:00 ～ 12:30 Symposium I At the front-line: Etiology of periodontitis Symposium Ⅱ Future is now! Stem cell revolution Video On-demand : 20 minutes each in hard and soft tissue engineering Q & A Live streaming : 10 minutes each 11:00 Video On-demand : 20 minutes each Q & A delivery time Q & A Live streaming : 10 minutes each 10:20-10:30 Dr. Toru Takeshita 10:50-11:00 Dr. Masaaki Nakayama Q & A delivery time 11:20-11:30 Dr. Masayuki Tukazaki 10:20-10:30 Dr. Shinsuke Oba 11:50-12:00 Dr. Atsuo Amano 10:50-11:00 Dr. Chisa Shukunami 11:20-11:30 Dr. Sachiko Iseki 11:50-12:00 Dr. Takashi Nakamura 12:00 12:20-12:30 Dr. Akihiro Yamashita 12:15 ～ 13:00 Council Meeting / General Assembly 12:15-13:00 (Live streaming) 13:00 13:00 ～ 14:30 13:00 ～ 15:00 Rising Scientist Session Neuroscience Symposium Ⅲ Pathophysiological approach Video On-demand : 20 minutes each from oral function to systemic diseases Q & A Live streaming : 10 minutes each Video On-demand : 20 minutes each Q & A Live streaming : 10 minutes each 14:00 Q & A delivery time 13:20-13:30 Dr. Fumiya Kano 13:50-14:00 Dr. Ayano Katagiri Q & A delivery time 14:20-14:30 Dr. Jun Miyamoto 13:20-13:30 Dr. Noriatsu Shigemura 13:50-14:00 Dr. Takafumi Kato 14:20-14:30 Dr. Masamichi Shinoda 14:50-15:00 Dr. Toshihide Mizoguchi 15:00 16:00 ─ 5 ─ JADR Timetable November 7th(Sat.) - 21st.(Sat.) Video On-demand and Poster File distribution Keynote Lecture (Video On-demand distribution) Prof. Richard J. Lamont (Department Oral Immunology & Infectious Diseases, University of Louisville, School of Dentistry) “Porphyromonas gingivalis interactions with epithelial cells in the community context” Greeting from IADR President (Video On-demand distribution) Prof. Pamela Den Besten (President of IADR) Special Lecture (Video On-demand distribution) Prof. Joo-Cheol Park (President of KADR) “Tubular Dentin Regeneration and Its Clinical Application” Poster Presentation (On-demand distribution of presentation file (PDF)) ─ 6 ─ November 7th, Saturday, ~ November 21st, Saturday Keynote Lecture (Video On-demand distribution) KL Porphyromonas gingivalis interactions with epithelial cells in the community context Dr. Richard J Lamont (Department Oral Immunology & Infectious Diseases, University of Louisville, School of Dentistry) Greeting from IADR President (Video On-demand distribution) G Dr. Pamela Den Besten (Department of Orofacial Sciences, School of Dentistry, University of California San Francisco) Special Lecture (Video On-demand distribution) SL Tubular Dentin Regeneration and Its Clinical Application Dr. Joo-Cheol Park (Laboratory for the Study of Regenerative Dental Medicine, Department Oral Histology-Developmental Biology, School of Dentistry, Seoul National University) Symposium Ⅰ~Ⅲ, Rising Scientist Session (Lecture;Video On-demand distribution / Q & A;Live streaming) ─ 7 ─ November 7th, Saturday 10:00-12:00 Symposium I “At the front-line: Etiology of periodontitis” Moderator: Dr. Kazuyuki Ishihara (Department of Microbiology, Tokyo Dental College, Tokyo, Japan) Moderator: Dr. Yoshihisa Yamashita (Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth and Development, Faculty of Dental Science, Kyushu University, Fukuoka, Japan) SⅠ-1 Bacterial composition of overall oral microbiota associated with periodontal disease and health. Dr. Toru Takeshita (Section of Preventive and Public Health Dentistry, Faculty of Dental Science, Kyushu University) SⅠ-2 The significant role of Porphyromonas gingivalis “Gingipains” as a virulence factor on periodontal inflammation Dr. Masaaki Nakayama1, Dr. Naoya Ohara2 (1Department of Microbiology, Graduate school of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2Advanced Research Center for Oral and Craniofacial Sciences (ARCOCS), Dental School, Okayama University) SⅠ-3 Periodontitis as an “osteoimmune” disease Dr. Masayuki Tsukazaki (Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo) SⅠ-4 Epithelial barrier breakdown by Porphyromonas gingivalis Dr. Atsuo Amano, Dr. Hiroki Takeuchi (Department of Preventive Dentistry, Graduate School of Dentistry, Osaka University) 13:00-14:30 Rising Scientist Session “Neuroscience” Moderator: Dr. Tazuko Goto (Department of Oral and Maxillofacial Radiology, Tokyo Dental College, Tokyo, Japan) RS-1 Factors secreted from dental pulp stem cells show multifaceted benefits for Synergistically Regenerate Transected Rat Peripheral Nerves by Altering Macrophage Polarity. Dr. Fumiya Kano (Department of Tissue regeneration Institute of Biomedical Sciences, Tokushima University Graduate School) RS-2 Phenotypic and neuroplastic changes in trigeminal nociceptive pathways following trigeminal nerve injury Dr. Ayano Katagiri (Department of Oral Physiology, Osaka University Graduate School of Dentistry, Suita, Japan) RS-3 The human brain and mastication; broad impact on systemic functions Dr. Jun Miyamoto ─ 8 ─ (Department of Maxillofacial Orthognathics, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU)) ─ 9 ─ November 8th, Sunday 10:00-12:30 SymposiumⅡ “Future is now! Stem cell revolution in hard and soft tissue engineering” Moderator: Dr. Toshifumi Azuma (Department of Biochemistry, Tokyo Dental College, Tokyo, Japan) Moderator: Dr. Shinsuke Oba (Department of Cell Biology, Institute of Biomedical Sciences, Nagasaki University) SⅡ-1 Generation of skeletal cells from pluripotent stem cells Dr. Shinsuke Oba (Department of Cell Biology,