Supplementary Table 5. Pooled analysis of global gene expression: Downregulated genes Criteria: 1) Signal-to-Noise ratio < -1.4 2) Fold Change < 0.5 (2 fold decrease after IPI-504 treatment) Down-regulated genes (101) NAME DESCRIPTION FC (Rx/NoRx) S2N P-value 1 ABCB8 ABCB8:ATP-binding cassette, sub-family B (MDR/TAP), member 8 0.09 -1.48 0.023 2 ACD ACD:adrenocortical dysplasia homolog (mouse) 0.40 -1.46 0.006 3 ACTB ACTB:actin, beta 0.31 -1.66 0.016 4 ADAM2 ADAM2:ADAM metallopeptidase domain 2 (fertilin beta) 0.35 -1.50 0.017 5 ADAMTS13 ADAMTS13:ADAM metallopeptidase with thrombospondin type 1 motif, 13 0.45 -1.41 0.018 6 ANKRD52 ANKRD52:ankyrin repeat domain 52 0.35 -1.52 0.009 7 AP4B1 AP4B1:adaptor-related protein complex 4, beta 1 subunit 0.46 -1.65 0.009 8 APLN APLN:apelin, AGTRL1 ligand 0.26 -1.74 0.016 9 ARHGEF10L ARHGEF10L:Rho guanine nucleotide exchange factor (GEF) 10-like 0.49 -1.49 0.012 10 ATP13A5 ATP13A5:ATPase type 13A5 0.30 -1.52 0.023 11 AURKB AURKB:aurora kinase B 0.35 -1.53 0.015 12 BCAR1 BCAR1:breast cancer anti-estrogen resistance 1 0.48 -1.80 0.011 13 BLOC1S1 BLOC1S1:biogenesis of lysosome-related organelles complex-1, subunit 1 0.34 -1.41 0.023 14 BTBD14B BTBD14B:BTB (POZ) domain containing 14B 0.41 -1.75 0.010 15 CAMK2A CAMK2A:calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha 0.43 -1.53 0.019 16 CCDC70 CCDC70:coiled-coil domain containing 70 0.13 -1.80 0.006 17 CDC14C CDC14C:CDC14 cell division cycle 14 homolog C (S. cerevisiae) 0.04 -1.43 0.030 18 CDC20 CDC20:CDC20 cell division cycle 20 homolog (S. cerevisiae) 0.23 -1.43 0.013 19 CENPB CENPB:centromere protein B, 80kDa 0.47 -1.41 0.024 20 CFL1 CFL1:cofilin 1 (non-muscle) 0.33 -1.54 0.016 21 CHAF1A CHAF1A:chromatin assembly factor 1, subunit A (p150) 0.40 -1.42 0.002 22 CHCHD5 CHCHD5:coiled-coil-helix-coiled-coil-helix domain containing 5 0.33 -1.42 0.020 23 CHEK2 CHEK2:CHK2 checkpoint homolog (S. pombe) 0.41 -1.45 0.015 24 COPZ2 COPZ2:coatomer protein complex, subunit zeta 2 0.50 -1.93 0.009 25 CPSF3L CPSF3L:cleavage and polyadenylation specific factor 3-like 0.46 -1.44 0.012 26 CPZ CPZ:carboxypeptidase Z 0.29 -1.67 0.004 27 CRYGD CRYGD:crystallin, gamma D 0.39 -1.50 0.009 28 CST8 CST8:cystatin 8 (cystatin-related epididymal specific) 0.31 -1.40 0.024 29 DGCR8 DGCR8:DiGeorge syndrome critical region gene 8 0.37 -1.43 0.029 30 DNAHL1 DNAHL1:dynein, axonemal, heavy chain like 1 0.21 -2.55 0.002 31 DOT1L DOT1L:DOT1-like, histone H3 methyltransferase (S. cerevisiae) 0.37 -1.91 0.009 32 EDF1 EDF1:endothelial differentiation-related factor 1 0.42 -1.43 0.012 33 ENTPD6 ENTPD6:ectonucleoside triphosphate diphosphohydrolase 6 0.46 -1.45 0.001 34 EVI2B EVI2B:ecotropic viral integration site 2B 0.39 -1.42 0.013 35 FAM100B FAM100B:family with sequence similarity 100, member B 0.35 -1.58 0.008 36 FAM47A FAM47A:family with sequence similarity 47, member A 0.27 -1.46 0.029 37 FCHSD1 FCHSD1:FCH and double SH3 domains 1 0.20 -1.42 0.010 38 GJB3 GJB3:gap junction protein, beta 3, 31kDa (connexin 31) 0.41 -1.42 0.009 39 GLI4 GLI4:GLI-Kruppel family member GLI4 0.27 -1.57 0.022 40 GNAS GNAS:GNAS complex locus 0.33 -1.50 0.025 41 GPR144 GPR144:G protein-coupled receptor 144 0.31 -1.78 0.003 42 HRAS HRAS:v-Ha-ras Harvey rat sarcoma viral oncogene homolog 0.37 -1.46 0.014 43 HRK HRK:harakiri, BCL2 interacting protein (contains only BH3 domain) 0.38 -1.48 0.021 44 HSPB7 HSPB7:heat shock 27kDa protein family, member 7 (cardiovascular) 0.36 -1.60 0.003 45 IRF3 IRF3:interferon regulatory factor 3 0.45 -1.49 0.001 46 KCNG2 KCNG2:potassium voltage-gated channel, subfamily G, member 2 0.37 -1.43 0.010 47 KCNN1 KCNN1:potassium intermediate/small conductance calcium-activated channel 0.20 -4.43 0.000 48 KRT33A KRT33A:keratin 33A 0.38 -1.84 0.003 49 LAMP1 LAMP1:lysosomal-associated membrane protein 1 0.47 -1.46 0.021 50 LYL1 LYL1:lymphoblastic leukemia derived sequence 1 0.34 -1.49 0.025 51 MAP3K11 MAP3K11:mitogen-activated protein kinase kinase kinase 11 0.48 -1.74 0.004 52 MAPKAP1 MAPKAP1:mitogen-activated protein kinase associated protein 1 0.49 -1.54 0.010 53 MAZ MAZ:MYC-associated zinc finger protein (purine-binding transcription factor) 0.38 -1.41 0.013 54 MCM5 MCM5:MCM5 minichromosome maintenance deficient 5, cell division cycle 46 0.33 -1.55 0.016 55 MED25 MED25:mediator of RNA polymerase II transcription, subunit 25 homolog 0.29 -1.48 0.015 56 MRPS15 MRPS15:mitochondrial ribosomal protein S15 0.26 -1.43 0.017 57 MVP MVP:major vault protein 0.26 -1.48 0.024 58 MXD3 MXD3:MAX dimerization protein 3 0.39 -1.65 0.015 59 MYOHD1 MYOHD1:myosin head domain containing 1 0.39 -1.50 0.012 60 NFIX NFIX:nuclear factor I/X (CCAAT-binding transcription factor) 0.33 -1.47 0.012 61 NTN1 NTN1:netrin 1 0.42 -1.82 0.004 62 NUP210L NUP210L:nucleoporin 210kDa-like 0.27 -1.47 0.025 63 PARK7 PARK7:Parkinson disease (autosomal recessive, early onset) 7 0.41 -1.52 0.015 64 PHKG2 PHKG2:phosphorylase kinase, gamma 2 (testis) 0.17 -1.60 0.016 65 PORCN PORCN:porcupine homolog (Drosophila) 0.37 -1.52 0.025 66 PPIL2 PPIL2:peptidylprolyl isomerase (cyclophilin)-like 2 0.43 -1.44 0.027 67 PPP1R13L PPP1R13L:protein phosphatase 1, regulatory (inhibitor) subunit 13 like 0.41 -1.55 0.007 68 PPP1R2P9 PPP1R2P9:protein phosphatase 1, regulatory (inhibitor) subunit 2 pseudogene 9 0.22 -1.67 0.011 69 PPP2R5B PPP2R5B:protein phosphatase 2, regulatory subunit B (B56), beta isoform 0.41 -1.54 0.005 70 PSRC1 PSRC1:proline/serine-rich coiled-coil 1 0.36 -1.48 0.021 71 RALY RALY:RNA binding protein, autoantigenic 0.37 -1.49 0.017 72 RFNG RFNG:radical fringe homolog (Drosophila) 0.49 -1.56 0.008 73 S100A16 S100A16:S100 calcium binding protein A16 0.32 -2.06 0.006 74 SART1 SART1:squamous cell carcinoma antigen recognised by T cells 0.44 -1.42 0.024 75 SCYL1 SCYL1:SCY1-like 1 (S. cerevisiae) 0.31 -1.68 0.010 76 SIGIRR SIGIRR:single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 0.31 -1.50 0.016 77 SILV SILV:silver homolog (mouse) 0.18 -1.64 0.009 78 SLC25A33 SLC25A33:solute carrier family 25, member 33 0.40 -1.45 0.006 79 SLC6A15 SLC6A15:solute carrier family 6, member 15 0.48 -2.16 0.006 80 SMAD9 SMAD9:SMAD, mothers against DPP homolog 9 (Drosophila) 0.40 -1.41 0.004 81 SPTAN1 SPTAN1:spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 0.36 -1.61 0.019 82 ST14 ST14:suppression of tumorigenicity 14 (colon carcinoma) 0.33 -1.43 0.009 83 STK24 STK24:serine/threonine kinase 24 (STE20 homolog, yeast) 0.46 -1.41 0.008 84 TACC3 TACC3:transforming, acidic coiled-coil containing protein 3 0.26 -1.78 0.009 85 TAF10 TAF10:TAF10 RNA polymerase II, TATA box binding protein-associated factor 0.23 -1.52 0.018 86 TBCD TBCD:tubulin-specific chaperone d 0.28 -1.45 0.016 87 TMSB10 TMSB10:thymosin, beta 10 0.32 -1.56 0.020 88 TNFAIP8L1 TNFAIP8L1:tumor necrosis factor, alpha-induced protein 8-like 1 0.46 -1.69 0.002 89 TNIP2 TNIP2:TNFAIP3 interacting protein 2 0.43 -1.68 0.005 90 TRAF4 TRAF4:TNF receptor-associated factor 4 0.40 -1.41 0.006 91 TREML2 TREML2:triggering receptor expressed on myeloid cells-like 2 0.07 -1.55 0.024 92 TRIM11 TRIM11:tripartite motif-containing 11 0.46 -1.54 0.008 93 TRIM40 TRIM40:tripartite motif-containing 40 0.15 -1.44 0.032 94 TROAP TROAP:trophinin associated protein (tastin) 0.35 -1.42 0.029 95 TSSK1 TSSK1:testis-specific serine kinase 1 0.34 -1.40 0.029 96 TYK2 TYK2:tyrosine kinase 2 0.45 -1.60 0.000 97 VIPR2 VIPR2:vasoactive intestinal peptide receptor 2 0.25 -1.73 0.013 98 ZDHHC12 ZDHHC12:zinc finger, DHHC-type containing 12 0.34 -1.40 0.007 99 ZDHHC14 ZDHHC14:zinc finger, DHHC-type containing 14 0.30 -1.55 0.009 100 ZNF101 ZNF101:zinc finger protein 101 0.38 -1.44 0.007 101 ZNF513 ZNF513:zinc finger protein 513 0.27 -1.53 0.023.