LEGEMIDDELSTATISTIKK 2018:2 Reseptregisteret 2013–2017 Tema: Legemidler og eldre The Norwegian Prescription Database 2013–2017 Topic: Drug use in the elderly Reseptregisteret 2013–2017 Tema: Legemidler og eldre The Norwegian Prescription Database 2013–2017 Topic: Drug use in the elderly Christian Berg Hege Salvesen Blix Olaug Fenne Kari Furu Vidar Hjellvik Kari Jansdotter Husabø Irene Litleskare Marit Rønning Solveig Sakshaug Randi Selmer Anne-Johanne Søgaard Sissel Torheim Utgitt av Folkehelseinstituttet/Published by Norwegian Institute of Public Health Område for Helsedata og digitalisering Avdeling for Legemiddelstatistikk Juni 2018 Tittel/Title: Legemiddelstatistikk 2018:2 Reseptregisteret 2013–2017 / The Norwegian Prescription Database 2013–2017 Forfattere/Authors: Christian Berg, redaktør/editor Hege Salvesen Blix Olaug Fenne Kari Furu Vidar Hjellvik Kari Jansdotter Husabø Irene Litleskare Marit Rønning Solveig Sakshaug Randi Selmer Anne-Johanne Søgaard Sissel Torheim Acknowledgement: Julie D. W. Johansen (English text) Bestilling/Order: Rapporten kan lastes ned som pdf på Folkehelseinstituttets nettsider: www.fhi.no The report can be downloaded from www.fhi.no Grafisk design omslag: Fete Typer Ombrekking: Houston911 Kontaktinformasjon/Contact information: Folkehelseinstituttet/Norwegian Institute of Public Health Postboks 222 Skøyen N-0213 Oslo Tel: +47 21 07 70 00 ISSN: 1890-9647 ISBN: 978-82-8082-926-9 Sitering/Citation: Berg, C (red), Reseptregisteret 2013–2017 [The Norwegian Prescription Database 2013–2017] Legemiddelstatistikk 2018:2, Oslo, Norge: Folkehelseinstituttet, 2018. Tidligere utgaver / Previous editions: 2008: Reseptregisteret 2004–2007 / The Norwegian Prescription Database 2004–2007 2009: Legemiddelstatistikk 2009:2: Reseptregisteret 2004–2008 / The Norwegian Prescription Database 2004–2008 2010: Legemiddelstatistikk 2010:2: Reseptregisteret 2005–2009. Tema: Vanedannende legemidler / The Norwegian Prescription Database 2005–2009. Topic: Addicitiv drugs 2011: Legemiddelstatistikk 2011:2: Reseptregisteret 2006–2010 / The NorwegianPrescription Database 2006–2010 2012: Legemiddelstatistikk 2012:2: Reseptregisteret 2007–2011. Tema: Legemidler og eldre / The Norwegian Prescription Database 2007–2011. Topic: Drug use in the elderly 2013: Legemiddelstatistikk 2013:2: Reseptregisteret 2008–2012 / The Norwegian Prescription Database 2008–2012 2014: Legemiddelstatistikk 2014:2: Reseptregisteret 2009–2013 / The Norwegian Prescription Database 2009–2013 2015: Legemiddelstatistikk 2015:2: Reseptregisteret 2010–2014. Tema: Antibiotika / The Norwegian Prescription Database 2010–2014. Topic: Antibiotics 2016: Legemiddelstatistikk 2016:2: Reseptregisteret 2011–2015 / The NorwegianPrescription Database 2011–2015 2017: Legemiddelstatistikk 2017:2: Reseptregisteret 2012–2016 / The Norwegian Prescription Database 2012–2016 Innhold Forord ........................................................................................................................................................................7 1. Legemidler og eldre ................................................................................................................................................8 1.1 Legemiddelbruk hos eldre (≥ 65 år) – noen nøkkeltall .............................................................................................. 8 1.2 Bruk av legemidler mot aldersdemens .................................................................................................................... 15 1.3 Bruk av legemidler ved hjerte- og karsykdommer og antitrombotiske legemidler hos eldre .................................. 19 1.4 Bruk av legemidler mot osteoporose hos eldre ....................................................................................................... 24 1.5 Bruk av smertestillende legemidler hos eldre ........................................................................................................ 30 1.6 Bruk av sovemidler og beroligende midler hos eldre ............................................................................................. 34 1.7 Bruk av antibiotika hos eldre ................................................................................................................................... 37 2. Generelt om Reseptregisteret (NorPD) og legemiddelstatistikk ............................................................................40 2.1 Reseptregisteret ...................................................................................................................................................... 40 2.2 Nordiske reseptregistre .......................................................................................................................................... 44 2.3 Grossistbasert legemiddelstatistikk ........................................................................................................................ 44 2.4 Anatomisk Terapeutisk Kjemisk (ATC)-klassifikasjon................................................................................................ 45 2.5 Definert Døgndose (DDD) ........................................................................................................................................ 46 2.6 WHO Collaborating Centre for Drug Statistics Methodology .................................................................................. 47 3. Reseptregisteret (NorPD) 2013–2017 ....................................................................................................................48 3.1 Utvalgte nøkkeltall fra Reseptregisteret .................................................................................................................. 48 3.2 Reseptkategorier og refusjon av utgifter til legemidler ....................................................................................... 52 3.3 Beskrivelse av hovedtabellene ............................................................................................................................... 56 3.4 ATC main groups ...................................................................................................................................................... 60 3.5 ATC group A – Alimentary tract and metabolism..................................................................................................... 61 3.6 ATC group B – Blood and bloodforming organs ....................................................................................................... 72 3.7 ATC group C – Cardiovascular system ..................................................................................................................... 75 3.8 ATC group D – Dermatologicals ............................................................................................................................... 83 3.9 ATC group G – Genito urinary system and sex hormones ........................................................................................ 89 3.10 ATC group H – Systemic hormonal preparations, excl. sex hormones and insulins ............................................... 94 3.11 ATC group J – Antiinfectives for systemic use ........................................................................................................ 97 3.12 ATC group L – Antineoplastic and immunomodulating agents ............................................................................ 104 3.13 ATC group M – Musculo-skeletal system ............................................................................................................ 107 3.14 ATC group N – Nervous system ........................................................................................................................... 110 3.15 ATC group P – Antiparasitic products, insecticides and repellents ...................................................................... 120 3.16 ATC group R – Respiratory system ...................................................................................................................... 122 3.17 ATC group S – Sensory organs ............................................................................................................................. 127 3.18 ATC-group V – Various ......................................................................................................................................... 131 Noen forkortelser og definisjoner ..........................................................................................................................133 Definisjoner ...........................................................................................................................................................134 Folkemengde i Norge 2013–2017 (per 1. juli) .........................................................................................................134 Folkemengde etter alder i 2017 (per 1. juli) ............................................................................................................134 Liste over vitenskapelige publikasjoner basert på data fra Reseptregisteret per 31.12.2017 ...................................135 Legemiddelstatistikk 2018:2 • Folkehelseinstituttet 5 Contents Preface .......................................................................................................................................................................7 1. Drug use in the elderly ............................................................................................................................................8 1.1