ANNUAL REPORT 2013 2013 ANNUAL REPORT 2013 ANNUAL REPORT i-xii_Frontmatter_2013.indb i 27-08-2014 15:53:52 ANNUAL REPORT 2013 © 2014 by Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory One Bungtown Road Cold Spring Harbor, New York 11724 www.cshl.edu Managing Editors Philip Renna, Dagnia Zeidlickis Production Editor Rena Springer Science Writing Peter Tarr Copy Editors Dorothy Brown, Rena Springer Production Manager Denise Weiss Nonscientifi c Photography Constance Brukin, Gina Motisi Cover Designers Margot Bennett, Denise Weiss Front cover: Rainbow over Cold Spring Harbor; photography, Philip Renna i-xii_Frontmatter_2013.indb ii 27-08-2014 15:54:06 Contents Offi cers of the Corporation and Board of Trustees iv–v Governance vi Committees of the Board vii Kathryn Wasserman Davis (1907–2013) viii–ix Arthur M. Spiro (1925–2013) x–xi Colton Packer Wagner (1919–2013) xii PRESIDENT’S REPORT 1 Highlights of the Year 5 CHIEF OPERATING OFFICER’S REPORT 24 Long-Term Service 26 RESEARCH 27 Cancer: Gene Regulation and Cell Proliferation 29 Cancer: Genetics 55 Cancer: Signal Transduction 76 Neuroscience 107 Plant Biology 170 Genomics 198 Quantitative Biology 228 Quantitative Biology Fellow 244 Author Index 248 WATSON SCHOOL OF BIOLOGICAL SCIENCES 251 Dean’s Report 253 Spring Curriculum 267 Fall Curriculum 271 Postdoctoral Program 275 Undergraduate Research Program 278 Partners for the Future 281 MEETINGS & COURSES PROGRAM 283 Academic Affairs 285 Symposium on Quantitative Biology 287 Meetings 290 Postgraduate Courses 357 Seminars 421 BANBURY CENTER 423 Executive Director’s Report 425 Meetings 429 DNA LEARNING CENTER 487 Executive Director’s Report 489 2013 Workshops, Meetings, Collaborations, and Site Visits 507 Sites of Major Faculty Workshops 511 COLD SPRING HARBOR LABORATORY PRESS 517 2013 Press Publications 518 Executive Director’s Report 519 FINANCE 521 Financial Statements 522 Financial Support of the Laboratory 525 Corporate Sponsor Program for Meetings Support 536 Development 537 LABORATORY MANAGEMENT 547 iii i-xii_Frontmatter_2013.indb iii 27-08-2014 15:54:06 Offi cers of the Corporation Jamie C. Nicholls, Chairman Paul J. Taubman, Secretary Robert D. Lindsay, Vice Chairman Bruce Stillman, Ph.D., President and Marilyn H. Simons, Vice Chairman Chief Executive Offi cer Leo A. Guthart, Treasurer W. Dillaway Ayres, Jr., Chief Operating Offi cer Board of Trustees Individual Trustees David Boies Charles I. Cogut Jacob Goldfi eld Leo A. Guthart Jeffrey E. Kelter Laurie J. Landeau, V.M.D. Chairman, Boies, Schiller & Partner, Simpson Thacher & New York, New York Founder and CEO, Senior Partner and CEO, General Manager, Listowel, Flexner LLP Barlett LLP Topspin Partners KTR Capital Partners Inc. Thomas D. Lehrman Robert D. Lindsay Robert W. Lourie, Ph.D. Howard L. Morgan, Jamie C. Nicholls Louise M. Parent CEO, MasterStreet Co-Managing Partner, Head of Future Research, Ph.D. Chairman of the Board Executive Vice President Lindsay Goldberg Renaissance Technologies Partner, First Round New York, New York and General Counsel, Corp Capital, Director, Idealab American Express Company John C. Phelan Thomas C. Quick William S. Robertson George Sard Thomas A. Saunders III Marilyn H. Simons, Ph.D. Managing Partner, Palm Beach, Florida Robertson Foundation Chairman and CEO, CEO, Ivor & Co., President, The Simons MSD Capital, L.P. for Government Sard Verbinnen & Co. LLC Foundation Dinakar Singh James M. Stone, Ph.D. Paul J. Taubman Edward Travaglianti Sandra Tytel Roy J. Zuckerberg Founding Partner, Chairman, The Plymouth New York, New York President, TD Bank Mill Neck, New York Senior Director, Goldman TPG-Axon Capital Rock Company Long Island Sachs & Co. iv i-xii_Frontmatter_2013.indb iv 27-08-2014 15:54:06 Scientifi c Trustees Tania A. Baker, Ph.D. Cornelia Isabella Bargmann Michael R. Botchan, Ph.D. David Botstein, Ph.D. Charles L. Sawyers, M.D. E.C. Whitehead Professor, Investigator, HHMI; Torsten Professor of Biochemistry; Anthony B. Evnin Professor Investigator, HHMI; Massachusetts Institute of N. Wiesel Professor, The and Chairman, Department of Genomics; Director, Chairman, Oncology & Technology, Investigator, Rockefeller University of Molecular and Cell Biol- Lewis Sigler Institute, Pathogenesis, Memorial HHMI ogy, University of California, Princeton University Sloan-Kettering Cancer Berkeley Center Samuel L. Stanley, Bruce Stillman, Ph.D. Jr., M.D. President and CEO, Cold President, Stony Brook Spring Harbor Laboratory University Honorary Trustees Bayard Clarkson, M.D. Norris W. Darrell Charles F. Dolan Helen Ann Dolan Lola N. Grace Memorial Sloan-Kettering Senior Counsel, Cablevision Systems Corp. Cablevision Systems Corp. Founder, Middle East Cancer Center Sullivan & Cromwell LP Children’s Institute David H. Koch Mary D. Lindsay David L. Luke III Nancy Abeles Marks Eduardo G. Mestre Koch Industries, Inc. Laurel Hollow, New York New York, New York Nancy Marks Interiors & Vice Chairman, Carl Marks & Co., Inc. Evercore Partners William R. Miller Alan Seligson James D. Watson, Ph.D. Henry Wendt III New York, New York NAK International Chancellor Emeritus, Cold Friday Harbor, Washington Spring Harbor Laboratory i-xii_Frontmatter_2013.indb v 27-08-2014 15:54:23 CSHL Scientific Advisory Council The Scientific Advisory Council (SAC) is an external advisory group that advises Cold Spring Harbor Laboratory’s (CSHL) senior management on matters pertaining to science (both current and future), including the development of a research strategy to maintain CSHL as a world leader. The SAC is a nine-member Council, including a Chair of Council who is an individual known for scientific breadth and a detailed understanding of research management at the senior management level. The other eight members are world leaders in their respective fields and as such are able to provide advice on the different research areas of the Laboratory. Fred Alt, Ph.D. (Chair) Markus Meister, Ph.D. HHMI Investigator/Harvard University California Institute of Technology Professor and Co-Chief, Division of Molecular Medicine, Professor, Molecular and Cellular Biology Children’s Hospital Boston Kevan Shokat, Ph.D. Cori Bargmann, Ph.D. HHMI Investigator/University of California, HHMI Investigator/The Rockefeller University San Francisco; University of California, Berkeley Professor, Laboratory of Neural Circuits and Behavior Professor and Chair, Cellular and Molecular Pharmacology; Professor of Chemistry Joanne Chory, Ph.D. HHMI Investigator/The Salk Institute for Biological Studies Max Wicha, M.D. Professor and Director, Plant Biology Laboratory University of Michigan Professor and Director, University of Michigan Carol Greider, Ph.D. Comprehensive Cancer Center Johns Hopkins School of Medicine Professor and Director of Molecular Biology & Genetics Leonid Kruglyak, Ph.D. HHMI Investigator/University of California, Los Angeles Professor, Human Genetics and Department of Biological Chemistry vi i-xiv_Frontmatter_2013.indb 6 10/23/2014 1:16:13 PM Governance The Laboratory is governed by a Board of Trustees of up to 35 members that meets three or four times a year. Authority to act for the Board of Trustees between meetings is vested in the Executive Committee of the Board of Trustees. The Executive Committee is composed of the Offi cers of the Board and any other members who may be elected to the Executive Committee by the Board of Trustees. Additional standing and ad hoc committees are appointed by the Board of Trustees to provide guidance and advice in specifi c areas of the Laboratory’s operations. Representation on the Board of Trustees itself is divided between business and community leaders and scientists from major educational and research institutions. The Laboratory is chartered as an educational and research institution by the Board of Regents of the Education Department of the State of New York. It is authorized to operate a graduate program under the name “Cold Spring Harbor Laboratory, Watson School of Biological Sciences” and thereat to confer the degrees of Doctor of Philosophy (Ph.D.), Master of Science (M.S.), and Doctor of Science (Sc.D.), Honorary. It is designated as a “public charity” under Section 501(c)(3) of the Internal Revenue Code. vi i-xii_Frontmatter_2013.indb vi 27-08-2014 15:54:35 Committees of the Board Academic Affairs Dinakar Singh Marilyn H. Simons, Ph.D. Bruce Stillman, Ph.D. Edward Travaglianti James M. Stone, Ph.D., Chair Paul J. Taubman W. Dillaway Ayres, Jr. Roy J. Zuckerberg Tania A. Baker, Ph.D. Investment Michael R. Botchan, Ph.D. Laurie J. Landeau, V.M.D. DNA Learning Center John C. Phelan, Chair Thomas D. Lehrman W. Dillaway Ayres, Jr. Bruce Stillman, Ph.D. Laurie J. Landeau, V.M.D., Chair Thomas D. Lehrman W. Dillaway Ayres, Jr. Jamie C. Nicholls Edward A. Chernoff William S. Robertson Audit Maria de Lesseps Dinakar Singh Suzanne Leeds Edward Travaglianti Leo A. Guthart, Chair David A. Micklos Remy Trafelet Louise M. Parent Bruce Stillman, Ph.D. Edward Travaglianti Nominating Commercial Relations Executive Louise Parent, Chair James M. Stone, Ph.D., Chair Jamie C. Nicholls, Chair W. Dillaway Ayres, Jr. W. Dillaway Ayres, Jr. W. Dillaway Ayres, Jr. Charles I. Cogut David Botstein, Ph.D. Leo A. Guthart Leo A. Guthart John P. Maroney, Esq. Marilyn H. Simons, Ph.D. Robert D. Lindsay Robert Martienssen, Ph.D. Bruce Stillman, Ph.D. Jamie C. Nicholls Bruce Stillman, Ph.D. James M. Stone, Ph.D. Bruce Stillman, Ph.D. Paul J. Taubman Paul J. Taubman Edward Travaglianti Roy J. Zuckerberg Development Sandra Tytel Roy J. Zuckerberg Marilyn H.