FREE BREAKTHROUGH: ELIZABETH HUGHES, THE DISCOVERY OF INSULIN, AND THE MAKING OF A MEDICAL MIRACLE PDF Thea Cooper,Arthur Ainsberg | 320 pages | 11 Nov 2011 | Griffin Publishing | 9780312611743 | English | California, United States Home - Arthur Ainsberg Goodreads helps you keep track of books you want to read. Want to Read saving…. Want to Read Currently Reading Read. Other editions. Enlarge cover. Error rating book. Refresh and try again. Open Preview See a Problem? Details if other :. Thanks for telling us about the Discovery of Insulin problem. Return to Book Page. Preview — Breakthrough by Thea Cooper. Arthur Ainsberg. It is and Elizabeth Hughes, the eleven-year-old daughter of America's most-distinguished jurist and politician, Charles Evans Hughes, has been diagnosed with juvenile diabetes. It is essentially a death sentence. The only accepted form of treatment - starvation - whittles her down to forty-five pounds skin and bones. Miles away, Canadian researchers Frederick Banting It is and Elizabeth Hughes, the eleven-year-old daughter of America's most-distinguished jurist and politician, Charles Evans Hughes, has been diagnosed with juvenile diabetes. Miles away, Canadian researchers Frederick Banting and Charles Best manage to identify and purify insulin from animal pancreases - a miracle soon marred by scientific jealousy, intense business competition and fistfights. In a race against time and a ravaging disease, Elizabeth becomes one of the first diabetics to receive insulin injections - all while its discoverers and a little known pharmaceutical company struggle to make it available to the rest of the world. Relive the heartwarming true story of the discovery of insulin as it's never been told before. Written with authentic detail and suspense, and featuring walk-ons by William Howard Taft, Woodrow Wilson, and Eli Lilly himself, among many others. Get A Copy. Hardcoverpages. More Details Other Editions 6. Friend Reviews. To see what your friends thought of this book, please sign up. To ask other readers questions about Breakthroughplease sign up. Lists with This Book. Community Reviews. Showing Average rating 4. And the Making of a Medical Miracle details. More filters. Sort order. Oct 11, Lisa rated it it was amazing Shelves: the Discovery of Insulinnonfictionscience. I realize that I might be the only one interested in reading this book about the discovery of insulin, but if you've ever known or know someone who needs to take insulin to stay alive, this book is Breakthrough: Elizabeth Hughes The authors follow the scientists who discovered how to extract, use and distribute insulin, and also weave the story of a girl with diabetes and an influential mother and father. I often thank God for those who contributed to the discovery of insulin and all the tools that go along with I realize that I might be the only one interested in reading this book about the discovery of insulin, but if you've ever known or know someone who needs to take insulin to stay alive, this book is fascinating! I often thank God for those who contributed to the discovery of insulin and all the tools that go along and the Making of a Medical Miracle managing diabetes, but now I have names for my prayers. Here's an amazing factoid: before the discovery and use of insulin, patients followed a calorie DAILY diet. Only calories!! Even with that, their life was only extended for 1 year. I'm in the Discovery of Insulin 28th year! I don't often do this, but I'm going to share a passage from the book that touched me and made me cry the heaving kind of messy cry. I hope I don't get in trouble for quoting some of this dialogue. This and the Making of a Medical Miracle a dialogue between the man who created insulin, Dr. Fredrick Banting and Elizabeth Hughes before she receives her first insulin injection: Dr. Banting: "The only question I have is when would you like to start getting better," he said. Elizabeth could see now that it was a kind of the Discovery of Insulin and that there was nothing inside but two small brown glass vials. She watched him closely. He swabbed her thigh with alcohol. She watched him fill the syringe. Just before he injected her he asked, "will you promise me one thing, Miss Elizabeth Hughes? Will you promise me that if you get well - when you get well - you will grow up to be whoever and whatever you want to be and you won't let anyone persuade you to do or be something or someone else? Or perhaps she had caught a glimpse of a profound loneliness behind his eyes. In any case she nodded solemnly, just before the needle pierced her meager hip. She flinched but did not look away the Discovery of Insulin Banting squeezed the plunger, pressing the murky beige extract into her flesh. Neither Banting nor Elizabeth spoke. Then Banting turned away to discard the empty vial. He placed the vial the Discovery of Insulin in her palm. She closed her fingers around it. I need a tissue View 2 comments. The low rating I gave to this book is due to the authors use of fictionalized episodes in the the Discovery of Insulin. The authors disclose this practice, so there is no deception, and I and the Making of a Medical Miracle that it does Breakthrough: Elizabeth Hughes the story-telling flow better than admitting that the authors had to hypothesize what had happened. But I think it is a dubious procedure in a non-fiction book and should be avoided. Breakthrough is about the discovery of a practical way of providing diabetics with insulin in the s. Elizabeth Hughes Go The low rating I gave to this book is due to the authors use of fictionalized episodes in the text. Elizabeth Hughes Gossett, daughter of Supreme And the Making of a Medical Miracle Justice, New York governor, and Secretary of State Charles Hughes was one of the first patients to recieve this treatment when it first became available. Elizabeth had been diagonised at having diabetes at age Before recieving insulin, Elizabeth had been on a starvation diet about calories per day for several years to keep her alive; she survived on this regime for years, much longer than expected. This diet had been developed by Dr. Frederick M. Allen, who ran Breakthrough: Elizabeth Hughes sanitarium in New Jersey were Elizabeth receieved some of her treatment. Several medical doctors and scientists in Canada, working at the University of toronto, developed a way of isolating insulin from animal pancreatic tissue. This development was marred by a good deal of conflict among those involved. Frederick Banting, a surgeon, seems to be the member of the Canadian group who the Discovery of Insulin of a surgical and the Making of a Medical Miracle to collect insulin, though he was unaware the idea had been suggested before. Banting, however, got it to work in dogs and also, from his farming background, realized that slaughterhouses for cattle could often provide fetal calves which would be an excellent source of insulin, as the calves would not have Breakthrough: Elizabeth Hughes secreting another enzyme that would have destroyed insulin. Macleod at the University of Toronto provided support and lab space to the unknown Banting. MacLoed also got an undergraduate in biochemistry, charles Best, to work with Banting Breakthrough: Elizabeth Hughes the project; Best made important contributions and from his subsequent career must have been a skillful scientist. Bertram Collip, a professor of biochemistry from the University of Alberta, who was on a fellowship at the University of Toronto at the time, made important contributions in purifying the extract. Banting and Macleod were jointly awarded the Nobel Prize inbut as they were not on speaking terms by then they did not attend the ceremony in Stockholm. The Eli Lilly company in Indianopolis was crucial in scaling up the procedure and commercializing it. Insulin was one of the earlier examples of academic researchers and a pharmaceutical company working together, with all the patent and intellectual property issues that such collaborations bring up. Among the fictionalized episodes was the dramatic nightime removal of Elizabeth, by her mother Antoinette, from the sanitarium run by Breakthrough: Elizabeth Hughes Allen and subsequent transporation to Ontario for insulin treatment, and the means by which Elizabeth was jumped to the head of the line for insulin treatment when that was still experimental, supplies of insulin were very low, and numerous other parents was clamoring for the same favoritism. View 1 comment. Dec 08, Maureen Mahowald rated it liked it. As a mother of two Type 1 diabetics this book was a chilling reminder of how recently insulin was discovered. Less than years ago. Prior to its discovery the Discovery of Insulin diagnosis of Type 1 diabetes was a death sentence. This book provides an interesting historical narrative of the discovery and the dramatic personalities who, by chance, combined to discover a treatment which continues to save millions of lives every day. Jul 23, Brandi D'angelo rated it really liked it. This quote kind of sums up the blood, sweat and tears this man, and many others working with him, put into the discovery and production of insulin in Toronto, Canada Breakthrough is an amazing story… a miraculous story really. It follows two parallel lives, one of Elizabeth Hughes who was diagnosed with diabetes at age 12, which at that time was a death sentence, and that of Frederick Banting, who would discover a treatment that allowed Elizabeth to live to the age of The authors do a Breakthrough: Elizabeth Hughes job of describing the relentless tenacity that these researches had to overcome all the odds and obstacles they the Discovery of Insulin.