“This project has received funding from the European Union’s Seventh Programme for research, technological development and demonstration under grant agreement N°603946 FP7-ENV-2013- 603946 http://www.heals-eu.eu/ D12.1 Report on Prototype Design of the Geospatial Platform WP12 Exposure and Health Data Management Version number 2 Lead beneficiary: 11 - VTT Date: 31.3.2015 Nature: R - Report Dissemination level: PU - Public D12.1 – Report on Prototype Design of Geospatial Platform WP12: Exposure and Health Data Management Security: Public Author(s):WP12 Version:1.2 2/93 FP7-ENV-2013-603946 TABLE OF CONTENTS 1 INTRODUCTION.............................................................................................................. 6 2 REQUIREMENTS FOR THE HEALS GEODATABASE........................................... 6 3 DESCRIPTION OF THE HEALS GEODATABASE PLATFORM ........................... 9 3.1 General requirements....................................................................................................9 3.1.1 Support collection and access to datasets .....................................................................9 3.1.2 Web-based platform................................................................................................... 10 3.1.3 Flexible and interactive platform.................................................................................. 10 3.2 Data Contents.............................................................................................................. 10 3.2.1 Data.......................................................................................................................... 10 3.2.2 Documents and guidelines ......................................................................................... 10 3.2.3 External databases .................................................................................................... 10 3.3 Data Import.................................................................................................................. 11 3.3.1 Data import from HEALS EXHES study and HEALS cohort studies ............................... 11 3.3.2 Data import from EDMS and ODK survey databases.................................................... 11 3.3.3 Data import from individual exposure database............................................................ 11 3.3.4 Data import from omics tool (Agilent)........................................................................... 12 3.3.5 Data import from computational modelling tools .......................................................... 12 3.3.6 Data import from external databases ........................................................................... 12 3.4 Data Export ................................................................................................................. 12 3.5 Modelling support ....................................................................................................... 13 3.6 Data queries ................................................................................................................ 13 3.7 Data analysis ............................................................................................................... 13 3.8 Data visualisation ........................................................................................................ 13 3.9 Data formats................................................................................................................ 13 3.10 Compatibility with standards....................................................................................... 14 3.10.1 INSPIRE directive ...................................................................................................... 14 3.10.2 IPChem..................................................................................................................... 14 D12.1 – Report on Prototype Design of Geospatial Platform WP12: Exposure and Health Data Management Security: Public Author(s):WP12 Version:1.2 3/93 FP7-ENV-2013-603946 3.11 User groups ................................................................................................................ 14 3.12 Language .................................................................................................................... 15 4 IMPLEMENTATION OF THE HEALS PLATFORM................................................. 16 4.1 Storage........................................................................................................................ 16 4.2 User management and access control ........................................................................ 17 4.2.1 Roles ........................................................................................................................ 17 4.2.2 Users ........................................................................................................................ 17 4.3 Data supply ................................................................................................................. 18 4.3.1 Data upload............................................................................................................... 18 4.3.2 Data annotation ......................................................................................................... 18 4.3.3 Data import ............................................................................................................... 19 4.4 Data access ................................................................................................................. 19 4.4.1 Data query ................................................................................................................ 19 4.4.2 Data export ............................................................................................................... 19 4.4.3 Data visualization ...................................................................................................... 20 4.5 Technologies used ...................................................................................................... 20 5 APPENDIX A: EXTERNAL DATABASES ................................................................ 21 5.1 Data location ............................................................................................................... 21 5.2 Data time range ........................................................................................................... 21 5.3 Data on health measurements..................................................................................... 21 5.4 List of external databases ........................................................................................... 22 5.4.1 Chemical, physical and toxicological data .................................................................... 22 5.4.2 Biological data ........................................................................................................... 27 5.4.3 Genetic data.............................................................................................................. 29 5.4.4 Other biological data .................................................................................................. 32 5.4.5 Population data ......................................................................................................... 33 5.4.6 Other databases ........................................................................................................ 37 6 APPENDIX B: DOCUMENTS AND GUIDELINES .................................................. 39 6.1 Guidelines by World Health Organization (WHO) ........................................................ 39 6.2 European Commission (EC) policies and legislation .................................................. 46 D12.1 – Report on Prototype Design of Geospatial Platform WP12: Exposure and Health Data Management Security: Public Author(s):WP12 Version:1.2 4/93 FP7-ENV-2013-603946 6.2.1 Directives .................................................................................................................. 46 6.2.2 Regulations ............................................................................................................... 57 6.2.3 Other ........................................................................................................................ 58 6.3 Guidelines by United States Environmental Protection Agency (EPA)........................ 61 6.4 Standards .................................................................................................................... 66 6.4.1 International Organization for Standardization (ISO)..................................................... 66 6.4.2 European standards (EN) ........................................................................................... 72 6.4.3 National Standards of EU Member States ................................................................... 76 6.4.4 American Society for Testing and Materials (ASTM) International Standards ................. 76 6.5 Other documents and guidelines ................................................................................ 78 7 APPENDIX C: EXAMPLES OF DATA....................................................................... 90 7.1 An example of a common file format........................................................................... 90 7.2 Example of previous study questionnaire data coding ............................................... 92 7.3 Example of human biomonitoring data ......................................................................