USOO8956642B2 (12) United States Patent (10) Patent No.: US 8,956,642 B2 Hobot et al. (45) Date of Patent: Feb. 17, 2015 (54) BUPIVACAINE FORMULATION INA 4,735,804 A 4, 1988 Caldwell et al. POLYORTHOESTER CARRIER 4,758.436 A 7, 1988 Caldwell et al. 4,764,364 A 8, 1988 Heller et al. 4,765,973 A 8, 1988 Heller (75) Inventors: Christopher M. Hobot, Tonka Bay, MN 4,767,627 A 8, 1988 Caldwell et al. (US); Michael E. Benz, Ramsey, MN 4,780,319 A 10/1988 Zentner et al. (US); Keith R. Hildebrand, Houlton, 4,855,132 A 8, 1989 Heller et al. WI (US); Bryant J. Pudil, Plymouth, 4,898,928 A 2f1990 Heller et al. MN (US) 4.946,931 A 8, 1990 Heller et al. 4,957,998 A 9, 1990 Heller et al. (73) Assignee: Medtronic, Inc., Minneapolis, MN (US) 5,030,4575,013,821 A 7,5/1991 1991 N.Heller s et al. 5,108,755 A 4, 1992 Daniels et al. (*) Notice: Subject to any disclaimer, the term of this 5,211,951 A 5/1993 Sparer et al. patent is extended or adjusted under 35 35. A 1. E. gyet al. 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(51) 2/00 (2006.01) EP O 168277 B1 1, 1986 EP O 168277 B2 1, 1986 AOIN 43/40 (2006.01) A6 IK3I/445 (2006.01) (Continued) A6IL 3L/I6 (2006.01) OTHER PUBLICATIONS (52) U.S. Cl. CPC ............... A6 IK3I/445 (2013.01); A61L 3 1/16 Moniche et al., in Anesthesiology 2002, 96,725-741.* (2013.01); A61 L 2300/402 (2013.01); A61 L (Continued) 2300/602 (2013.01) USPC - - - - - - - - - - - grgrrr. 424/426; 514/330 Primary Examiner — Dennis Heyer (58) Field of Classification Search Assistant Examiner — Daniel M Podgorski O See application file for complete search history. Attorney, Agent, or Firm — Sorell Lenna & Schmidt (56) References Cited (57) ABSTRACT U.S. PATENT DOCUMENTS Effective treatments of pain, such as chronic pelvic pain, for 2.957.856. A 10, 1960 G 1 extended periods of time are provided. 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