PLATINblue MSQ Plus Hardware Guide V6950A UHPLC/HPLC Mass spectrometry 3 Content Preface . 8 Safety . 8 Fuses . 8 Lab regulations . 8 LC Solvents and Mobile Phase Additives . 8 LC Solvents . 8 Protective measures . 9 Safety precautions . 9 Solvent and Gas Purity Requirements . 11 Contacting Us . 11 To contact Technical Support or Customer Service for ordering information . 11 To suggest changes to documentation or to Help . 11 Introduction . 12 Overview . 12 Ion Polarity Modes . 13 Ionization Techniques . 14 Electrospray Ionization (ESI) . 14 Ion Desolvation Mechanism . 14 Spectral Characteristics . 15 Atmospheric Pressure Chemical Ionization (APCI) . 16 Ion Generation Mechanism . 16 Spectral Characteristics . 18 Scan Types . 18 Full Scan . 18 Selected Ion Monitoring (SIM) . 18 Data Types . 19 Profile Data Type . 19 Centroid Data Type . 20 MCA Data Type . 21 Functional Description. 22 Liquid Chromatograph . 23 To open the Instrument Configuration application . 23 Reference Inlet System . 25 Mass Detector . 27 Front Panel Status Indicator . 28 Rear Panel Controls and Connections . 29 Connection Between LC and Mass Detector . 31 API Sources . 31 V6950A 4 Electrospray Ionization (ESI) . 31 Atmospheric Pressure Chemical Ionization (APCI) . 33 RF/dc Prefilter . 34 Mass Analyzer . 35 RF and DC Fields Applied to the Quadrupoles . 35 Mass Analysis . 36 Ion Detection System . 37 Vacuum System . 39 Vacuum Manifold . 40 Turbomolecular Pump . 40 Forepump . 41 Pirani Gauge . 41 Vent Valve . 41 Inlet Gas Hardware . 42 Cone Wash System . 45 Data System . 46 Computer Hardware . 46 Xcalibur Software . 47 MSQ Plus Mass Detector Server . 49 Tune Window . 50 Title Bar . 51 Menu Bar . 51 Toolbar . 51 Comms Indicator . 51 Scan Events Table . 52 Per Method Parameters Table . 52 Peak Display . 52 Status Bar . 52 Printer . 52 Daily Operation . 53 Before Operating the Mass Detector . 53 Checking the Nitrogen Supply . 53 Checking the Disk Space . 53 To determine the amount of available disk space . 53 Checking the Oil Level in the Oil Mist Filter . 54 After Operating the Mass Detector . 54 Flushing the API Probes . 54 To flush the capillary of the API probe . 55 Placing the System in the Off Mode . 55 Draining the Oil Mist Filter and Purging the Pump Oil . 55 To drain the oil mist filter and purge volatile contaminants from the oil in the forepump . 56 Emptying the Solvent Waste Bottles . ..