Supplementary Tables Supplementary Table S1: Preselected miRNAs used in feature selection Univariate Cox proportional hazards regression analysis of the endpoint freedom from recurrence in the training set (DKTK-ROG sample) allowed the pre-selection of 524 miRNAs (P< 0.5), which were used in the feature selection. P-value was derived from log-rank test. miRNA p-value miRNA p-value miRNA p-value miRNA p-value hsa-let-7g-3p 0.0001520 hsa-miR-1304-3p 0.0490161 hsa-miR-7108-5p 0.1263245 hsa-miR-6865-5p 0.2073121 hsa-miR-6825-3p 0.0004257 hsa-miR-4298 0.0506194 hsa-miR-4453 0.1270967 hsa-miR-6893-5p 0.2120664 hsa-miR-668-3p 0.0005188 hsa-miR-484 0.0518625 hsa-miR-200a-5p 0.1276345 hsa-miR-25-3p 0.2123829 hsa-miR-3622b-3p 0.0005885 hsa-miR-6851-3p 0.0531446 hsa-miR-6090 0.1278692 hsa-miR-3189-5p 0.2136060 hsa-miR-6885-3p 0.0006452 hsa-miR-1276 0.0557418 hsa-miR-148b-3p 0.1279811 hsa-miR-6073 0.2139702 hsa-miR-6875-3p 0.0008188 hsa-miR-3173-3p 0.0559962 hsa-miR-4425 0.1288330 hsa-miR-765 0.2141536 hsa-miR-487b-5p 0.0011381 hsa-miR-650 0.0564616 hsa-miR-6798-3p 0.1293342 hsa-miR-338-5p 0.2153079 hsa-miR-210-5p 0.0012316 hsa-miR-6133 0.0571407 hsa-miR-4472 0.1300006 hsa-miR-6806-5p 0.2173515 hsa-miR-1470 0.0012822 hsa-miR-4701-5p 0.0571720 hsa-miR-4465 0.1304841 hsa-miR-98-5p 0.2184947 hsa-miR-6890-3p 0.0016539 hsa-miR-202-3p 0.0575741 hsa-miR-514b-5p 0.1308790 hsa-miR-500a-3p 0.2185577 hsa-miR-6511b-3p 0.0017165 hsa-miR-4733-5p 0.0616138 hsa-miR-378c 0.1317442 hsa-miR-4515 0.2187539 hsa-miR-7109-3p 0.0021381 hsa-miR-595 0.0629350 hsa-miR-3121-3p 0.1319386 hsa-miR-4510 0.2194305 hsa-miR-640 0.0033118 hsa-miR-4462 0.0633754 hsa-miR-6743-3p 0.1332837 hsa-miR-146a-5p 0.2220503 hsa-miR-6820-3p 0.0036195 hsa-miR-6763-5p 0.0636346 hsa-miR-1296-5p 0.1352142 hsa-miR-200b-3p 0.2245329 hsa-miR-3617-3p 0.0040518 hsa-miR-1238-3p 0.0638492 hsa-miR-1229-5p 0.1354426 hsa-miR-1273e 0.2247443 hsa-let-7d-3p 0.0040669 hsa-miR-200b-5p 0.0643827 hsa-miR-3607-5p 0.1358297 hsa-miR-181d-5p 0.2254029 hsa-miR-7152-5p 0.0041095 hsa-miR-3609 0.0669743 hsa-miR-3607-3p 0.1365370 hsa-miR-5572 0.2256737 hsa-miR-449b-3p 0.0044936 hsa-miR-2277-3p 0.0687210 hsa-miR-887-3p 0.1366652 hsa-miR-378g 0.2276769 hsa-miR-1227-3p 0.0047357 hsa-miR-4763-5p 0.0720451 hsa-miR-452-5p 0.1440784 hsa-miR-3189-3p 0.2301775 hsa-miR-1273d 0.0060961 hsa-miR-7111-5p 0.0730786 hsa-miR-4478 0.1463108 hsa-miR-758-5p 0.2320042 hsa-miR-3940-3p 0.0071343 hsa-miR-4428 0.0740150 hsa-miR-770-5p 0.1485178 hsa-miR-6730-5p 0.2331420 hsa-miR-6792-3p 0.0078134 hsa-miR-6840-3p 0.0759541 hsa-miR-140-3p 0.1500966 hsa-miR-1-3p 0.2372861 hsa-miR-7161-3p 0.0078813 hsa-miR-4455 0.0775395 hsa-miR-6812-3p 0.1518200 hsa-miR-605-5p 0.2396612 hsa-miR-6722-5p 0.0079627 hsa-miR-2117 0.0776026 hsa-miR-664a-3p 0.1521388 hsa-miR-4655-3p 0.2407594 hsa-miR-1910-5p 0.0086288 hsa-miR-494-3p 0.0786895 hsa-miR-1181 0.1533878 hsa-miR-6800-5p 0.2414789 hsa-miR-6509-5p 0.0087440 hsa-miR-18a-5p 0.0797662 hsa-miR-4746-3p 0.1547788 hsa-miR-6088 0.2420315 hsa-miR-204-5p 0.0096105 hsa-miR-5708 0.0799330 hsa-miR-1224-5p 0.1553392 hsa-miR-4685-5p 0.2422472 hsa-miR-6804-3p 0.0096618 hsa-miR-6752-3p 0.0805763 hsa-miR-128-1-5p 0.1556776 hsa-miR-6748-5p 0.2423384 hsa-miR-939-3p 0.0109262 hsa-miR-10a-5p 0.0814598 hsa-miR-616-3p 0.1565544 hsa-miR-4731-3p 0.2427330 hsa-miR-4306 0.0117792 hsa-miR-328-3p 0.0817575 hsa-miR-1908-3p 0.1581024 hsa-miR-3935 0.2429832 hsa-miR-3174 0.0141084 hsa-miR-92b-3p 0.0822815 hsa-miR-142-5p 0.1582806 hsa-miR-2467-3p 0.2441518 hsa-miR-4732-5p 0.0147261 hsa-miR-3162-5p 0.0839691 hsa-miR-4632-5p 0.1588593 hsa-miR-513c-5p 0.2444128 hsa-miR-33b-3p 0.0156521 hsa-miR-4280 0.0841550 hsa-miR-4449 0.1597510 hsa-miR-623 0.2445756 hsa-miR-6508-5p 0.0158996 hsa-miR-1539 0.0867762 hsa-miR-1183 0.1605472 hsa-miR-4767 0.2445884 hsa-miR-4324 0.0165290 hsa-miR-186-5p 0.0872225 hsa-miR-1291 0.1621822 hsa-miR-574-5p 0.2448785 hsa-miR-590-5p 0.0165776 hsa-miR-4642 0.0876855 hsa-miR-6500-5p 0.1635955 hsa-miR-4322 0.2453192 hsa-miR-6784-3p 0.0166261 hsa-miR-615-3p 0.0879593 hsa-miR-4648 0.1638468 hsa-miR-3202 0.2458438 hsa-miR-885-5p 0.0176496 hsa-miR-6876-5p 0.0891828 hsa-miR-6872-5p 0.1646751 hsa-miR-4257 0.2466355 hsa-miR-6821-5p 0.0184064 hsa-miR-708-5p 0.0897671 hsa-miR-762 0.1652679 hsa-miR-6851-5p 0.2479639 hsa-miR-7155-3p 0.0200061 hsa-miR-711 0.0898413 hsa-miR-5088-5p 0.1652707 hsa-miR-532-5p 0.2487441 hsa-miR-195-3p 0.0203311 hsa-miR-3137 0.0926017 hsa-miR-6753-3p 0.1657836 hsa-miR-6722-3p 0.2494773 hsa-miR-185-5p 0.0227247 hsa-miR-6865-3p 0.0963720 hsa-miR-6801-3p 0.1674969 hsa-miR-6165 0.2501110 hsa-miR-6787-3p 0.0227996 hsa-miR-6775-3p 0.0968004 hsa-miR-184 0.1679089 hsa-miR-6882-5p 0.2503938 hsa-miR-6747-5p 0.0237232 hsa-miR-4530 0.0981749 hsa-miR-23a-5p 0.1679222 hsa-miR-6886-5p 0.2513879 hsa-miR-6511a-3p 0.0238634 hsa-miR-663b 0.0995187 hsa-miR-101-3p 0.1680510 hsa-miR-492 0.2518110 hsa-miR-4506 0.0250136 hsa-miR-6837-5p 0.0997487 hsa-miR-5580-3p 0.1709154 hsa-miR-148a-3p 0.2534658 hsa-miR-191-3p 0.0252090 hsa-miR-4657 0.1002823 hsa-miR-6126 0.1714707 hsa-miR-1913 0.2545273 hsa-miR-4644 0.0254266 hsa-miR-429 0.1019673 hsa-miR-181b-5p 0.1716146 hsa-miR-550a-3-5p 0.2554465 hsa-miR-6730-3p 0.0286103 hsa-miR-301a-3p 0.1028710 hsa-miR-6858-3p 0.1729173 hsa-miR-6862-5p 0.2563177 hsa-miR-7108-3p 0.0286443 hsa-miR-1273h-5p 0.1041604 hsa-miR-874-3p 0.1735055 hsa-miR-4655-5p 0.2572530 hsa-miR-3660 0.0292502 hsa-miR-30c-1-3p 0.1054130 hsa-miR-1233-5p 0.1736421 hsa-miR-4725-3p 0.2582799 hsa-miR-4323 0.0292906 hsa-miR-4753-5p 0.1067460 hsa-miR-6778-5p 0.1745063 hsa-miR-422a 0.2597447 hsa-miR-3976 0.0293703 hsa-miR-1909-5p 0.1078986 hsa-miR-328-5p 0.1755199 hsa-miR-4421 0.2598836 hsa-let-7b-3p 0.0299364 hsa-miR-133b 0.1083123 hsa-miR-365b-5p 0.1800151 hsa-miR-3155b 0.2600660 hsa-miR-3972 0.0313027 hsa-miR-6848-3p 0.1100985 hsa-miR-4259 0.1818164 hsa-miR-6125 0.2610979 hsa-miR-4468 0.0324435 hsa-miR-548q 0.1103041 hsa-miR-130b-3p 0.1823601 hsa-miR-6847-5p 0.2618588 hsa-miR-4430 0.0339590 hsa-miR-7113-5p 0.1103884 hsa-miR-29c-5p 0.1827272 hsa-miR-6791-5p 0.2618956 hsa-miR-6800-3p 0.0362758 hsa-miR-425-3p 0.1130173 hsa-miR-378d 0.1866668 hsa-miR-4436b-3p 0.2620868 hsa-miR-4451 0.0363388 hsa-miR-6756-3p 0.1133662 hsa-miR-6873-5p 0.1883127 hsa-miR-339-3p 0.2621292 hsa-miR-4312 0.0368500 hsa-miR-6880-3p 0.1134722 hsa-miR-664b-5p 0.1916503 hsa-miR-141-3p 0.2628940 hsa-miR-378f 0.0389967 hsa-miR-3679-5p 0.1136289 hsa-miR-6777-3p 0.1938001 hsa-miR-516b-5p 0.2638307 hsa-miR-1273g-5p 0.0395595 hsa-miR-1237-3p 0.1148857 hsa-miR-1228-5p 0.1950725 hsa-miR-7150 0.2642509 hsa-miR-6877-3p 0.0413089 hsa-miR-3926 0.1155312 hsa-miR-99b-3p 0.1955799 hsa-miR-3151-3p 0.2646335 hsa-miR-6889-3p 0.0417185 hsa-miR-3154 0.1163788 hsa-miR-6781-5p 0.1963350 hsa-miR-4769-5p 0.2648458 hsa-miR-4695-3p 0.0424169 hsa-miR-6809-5p 0.1171788 hsa-miR-4497 0.1977408 hsa-miR-6796-3p 0.2663793 hsa-miR-1910-3p 0.0434879 hsa-miR-206 0.1174973 hsa-miR-30b-3p 0.2005012 hsa-miR-4634 0.2663950 hsa-miR-6515-3p 0.0443939 hsa-miR-1273h-3p 0.1176645 hsa-miR-4728-3p 0.2054719 hsa-miR-6758-5p 0.2722472 hsa-miR-4800-3p 0.0444738 hsa-miR-378e 0.1189653 hsa-miR-4282 0.2057643 hsa-miR-4538 0.2742868 hsa-miR-631 0.0462931 hsa-miR-1287-5p 0.1234996 hsa-miR-200a-3p 0.2069192 hsa-miR-133a-3p 0.2748945 hsa-miR-4441 0.0471482 hsa-miR-6516-3p 0.1254558 hsa-miR-3678-3p 0.2069721 hsa-miR-106b-5p 0.2751335 miRNA p-value miRNA p-value miRNA p-value miRNA p-value hsa-miR-4701-3p 0.2757559 hsa-miR-4800-5p 0.3389165 hsa-miR-483-5p 0.3982010 hsa-miR-769-3p 0.4622322 hsa-miR-4539 0.2772361 hsa-miR-4444 0.3390121 hsa-miR-4458 0.3983281 hsa-miR-26b-5p 0.4657563 hsa-miR-6819-3p 0.2773291 hsa-miR-6825-5p 0.3397772 hsa-miR-659-3p 0.3988127 hsa-miR-489-3p 0.4673496 hsa-miR-610 0.2775115 hsa-miR-135b-5p 0.3431898 hsa-miR-1207-5p 0.3988137 hsa-miR-4633-5p 0.4680045 hsa-miR-5006-5p 0.2776556 hsa-miR-423-5p 0.3433266 hsa-miR-4311 0.4000437 hsa-miR-8485 0.4684670 hsa-miR-330-3p 0.2787079 hsa-miR-144-3p 0.3437170 hsa-miR-6829-5p 0.4009580 hsa-miR-6861-5p 0.4689076 hsa-miR-1299 0.2787134 hsa-miR-6850-5p 0.3437688 hsa-miR-3663-3p 0.4058370 hsa-miR-7846-3p 0.4697262 hsa-miR-6766-3p 0.2788320 hsa-miR-1285-3p 0.3437961 hsa-miR-6788-5p 0.4065287 hsa-miR-4792 0.4722690 hsa-miR-4750-3p 0.2795178 hsa-miR-345-5p 0.3447189 hsa-miR-5195-5p 0.4068506 hsa-miR-664b-3p 0.4726302 hsa-miR-3620-3p 0.2803378 hsa-miR-3180-5p 0.3450154 hsa-miR-4743-5p 0.4071310 hsa-miR-3141 0.4738397 hsa-miR-4715-5p 0.2819552 hsa-miR-6762-5p 0.3461694 hsa-miR-933 0.4077111 hsa-miR-6834-3p 0.4760892 hsa-miR-93-5p 0.2836876 hsa-miR-6516-5p 0.3468279 hsa-miR-4317 0.4078686 hsa-miR-4429 0.4765072 hsa-miR-146b-5p 0.2853212 hsa-miR-760 0.3487637 hsa-miR-4769-3p 0.4085797 hsa-miR-4717-3p 0.4789832 hsa-miR-1301-5p 0.2857640 hsa-miR-4433a-5p 0.3497714 hsa-miR-3605-5p 0.4094209 hsa-miR-4261 0.4794872 hsa-miR-4676-5p 0.2866471 hsa-miR-151b 0.3498465 hsa-miR-10b-3p 0.4097002 hsa-miR-6739-5p 0.4795600 hsa-miR-3689a-5p 0.2871961 hsa-miR-197-3p 0.3501618 hsa-miR-31-5p 0.4134444 hsa-miR-7515 0.4796186 hsa-miR-200c-3p 0.2877486 hsa-miR-4498 0.3556529 hsa-miR-320c 0.4140729 hsa-miR-6787-5p 0.4806692 hsa-miR-4481 0.2885148 hsa-miR-5196-5p 0.3568088 hsa-miR-3122 0.4145644 hsa-miR-3162-3p 0.4819271 hsa-miR-3667-5p 0.2909124 hsa-miR-601 0.3579403 hsa-miR-6833-5p 0.4146008 hsa-miR-6769a-5p 0.4827356 hsa-miR-4651 0.2909279 hsa-miR-6763-3p 0.3580989 hsa-miR-374a-5p 0.4178368 hsa-miR-6074 0.4840659 hsa-miR-660-5p 0.2910990 hsa-miR-1295a 0.3585605 hsa-miR-5187-5p 0.4186474 hsa-miR-8063 0.4852187 hsa-miR-221-3p 0.2922822 hsa-miR-6132 0.3585949 hsa-miR-526b-5p 0.4197979 hsa-miR-320a