Contents Title: Creating an Otitis Media Research Network in Aboriginal Medical Services in Australia …………………………………………………………………………………………………12 Authors: L. Campbell1, S. Tyson2, R. Murray3, N. O'Connor3, S. Hussey4, N. Peter5, P. Abbott6 ................................................................................................................................................ 12 Title: Nasopharyngeal Microbiome Analysis in Healthy and Otitis-Prone Children: Focus on History of Spontaneous Tympanic Membrane Perforation ...................................................... 13 Authors: P. Marchisio1, F. Folino1, M. Fattizzo1, C. Tafuro2, L. Ruggiero1, M. Gaffuri3, S. Torretta3, S. Aliberti2 ................................................................................................................ 13 Title: Tubomanometry may describe Passive Properties of Eustachian Tubes in Ears with Intact Tympanic Membranes ................................................................................................... 15 Authors: A. Y. Lim1, M. S. Teixiera1, J. D. Swarts1, C. M. Alper1,2 .......................................... 15 Title: Management of acute respiratory tract infections including acute otitis media in Danish general practice…… ................................................................................................................ 16 Authors: J. Lous1, J. K. Olsen1, J. Lykkegaard1, M. P. Hansen1, F. B. Waldorff1, M. K. Andersen1 ................................................................................................................................ 16 Title: Pain Management in Acute Otitis Media: a Qualitative Study of Parents’ Views and Expectations ............................................................................................................................ 17 Authors: R. Venekamp1, R. Van Uum1, A. Schilder2, R. Damoiseaux1, S. Anthierens3 .......... 17 Title: Enhancing Otitis Media Clinical Trials through Qualitative Research ......................... 18 Authors: P. Abbott1, J. Reath1, C. Frede1, S. O'Brien1, W. Hu1, C. Bond2, R. Walsh1, D. Askew2 ..................................................................................................................................... 18 Title: NTHI and M. catarrhalis Released from a Polymicrobial Biofilm by Antibodies against NTHI Type IV Pili are Hypersensitive to Antibiotic Mediated Killing ......................................... 19 Authors: E. M. Mokrzan1, L. A. Novotny1, K. L. Brockman1, L. O. Bakaletz1,2 ......................... 19 Title: Rapid Gene Regulation by nontypeable Haemophilus influenzae Impacted Sensitivity to First-Line Antibiotics Used to Treat OM ............................................................................... 20 Authors: S. D. Stacey1,2, K. L. Brockman1,2, J. M. Atack3, M. P. Jennings3, S. D. Goodman1,2, L. O. Bakaletz1,2 ....................................................................................................................... 20 Title: Rapid Gene Regulation by nontypeable Haemophilus influenzae Resulted in Altered Adherence to Respiratory Tract Epithelial Cells and Mucus .................................................... 22 Authors: S. D. Stacey1,2, K. L. Brockman1,2, J. M. Atack3, M. P. Jennings3, L. O. Bakaletz1,2 . 22 Title: Immunization with a Bandaid Protects Against Experimental Otitis Media Due to nontypeable Haemophilus influenzae ...................................................................................... 24 Authors: L. A. Novotny1, L. O. Bakaletz1,2 ............................................................................... 24 1 Title: Antibody Against a Novel Chimeric Peptide Immunogen that Targets a Bacterial DNA- Binding Protein Integral to Biofilm Structural Integrity Resolves Experimental Otitis Media .... 25 Authors: L. A. Novotny1, S. D. Goodman1,2, L. O. Bakaletz1,2 ................................................. 25 Title: Contact with Host Respiratory Tract Epithelial Cells Upregulates NTHI Expression of the Vaccine Candidate Antigen PilA ........................................................................................ 26 Authors: E. M. Mokrzan1, T. J. Johnson1, L. O. Bakaletz1,2 .................................................... 26 Title: The Transcriptional Landscape of the In Vitro Murine Middle Ear Epithelium. ........... 27 Authors: A. Mulay1,2, M. Chowdhury1, L. Bingle1, C. D. Bingle1 .............................................. 27 Title: Eradication of Biofilms on Tympanostomy Tubes with Acetic Acid Treatment; An In Vitro Study ............................................................................................................................... 28 Authors: M. Kjeldsen1,2, P. Homøe1,4, A. K. Nielsen2, S. Crone2, K. N. Kragh2,3, T. Bjarnsholt2,3 ................................................................................................................................................ 28 Title: Waiting to Hear: The Impact of Otitis Media with Effusion (OME) on Quality of Life of Aboriginal and non-Aboriginal Children from Urban, Regional and Rural Areas of New South Wales, Australia. ...................................................................................................................... 29 Authors: K. M. Kong1,2,3,4, S. T. Hall1,3, B. Hall1, K. Palazzi3, R. Eisenberg2, N. Jefferson2, D. Cope2, J. Huang2, T. Corlette2, C. Blackwell1,3 ........................................................................ 29 Title: Non-Invasive, Cross-Sectional Optical Middle Ear Imaging Compared with Acoustic Measurements during Otitis Media .......................................................................................... 31 Authors: J. Won1,2, G. L. Monroy1,2, P. Huang1,2, M. C. Hill3,4, M. A. Novak3,5, R. G. Porter3,5, D. R. Spillman2, R. Barkalifa2, E. J. Chaney2, S. A. Boppart1,2,3,6 ............................................ 31 Title: Deciphering Deafness in Down Syndrome: Finding the Otitis Media Gene .................... 33 Authors: A. Southern1,5, D. J. Williams1, S. Wells2, E. Lana-Elola3, S. Watson-Scales3, V. L. Tybulewicz3, E. Fisher4, H. Tateossian1, S. D. Brown1 ............................................................ 33 Title: Otitis Media in Down Syndrome: Towards Identification of the Gene for OM Using Mouse Models ......................................................................................................................... 35 Authors: H. Tateossian1, T. Purnell1, E. Lana-Elola2, S. Watson-Scales2, H. Cater4, S. Wells4, V. L. Tybulewicz2, E. M. Fisher3, S. D. Brown1 ........................................................................ 35 Title: Otitis Media and Primary Ciliary Dyskinesia: Impact of Disease ................................ 36 Authors: E. Muhonen1, J. Bhatt3, S. Sagel2, K. Chan2 ............................................................ 36 Title: Candidatus Ornithobacterium hominis: an Important but Under-Recognised Nasopharyngeal Bacterium? ................................................................................................... 37 R. L. Marsh1, K. A. Lawrence1, T. M. Harris1, S. J. Salter2, R. W. Hall1, H. C. Smith-Vaughan1, A. B. Chang1,3 .......................................................................................................................... 37 Title: A2ML1 and Otitis Media: Novel Variants, Differential Expression and Relevant Pathways ................................................................................................................................. 38 2 Authors: R. Santos-Cortez1,2,3, E. Larson1, M. Scholes1,6, J. Prager1,6, P. Yoon1,6, T. Wine1,6, N. Friedman1,6, K. Chan1,6, P. Mattila7, Z. Ahmed8, L. Hafren7, H. Jenkins1, C. Chiong2,4,5 ..... 38 Title: Surgical Outcomes of Ossiculoplasty Following Tympanomastoidectomy and Comparison with Polycel® and Titanium Prostheses ............................................................... 39 Authors: O. Choo1, H. Kim1, J. Jang1, H. Park1, Y. Choung1 .................................................. 39 Title: The Effectiveness of Ventilation Tube Insertion in Cleft Palate Patients .................... 40 Authors: O. Choo, H. Kim1, J. Jang1, H. Park1, Y. Choung1 .................................................... 40 Title: Extrusion rate and complications according to the type of ventilation tube: Multicenter registry study on the effectiveness of ventilation tube insertion in pediatric patients with chronic otitis media with effusion—Part II…………………………………………………………………....41 Authors: M. Yoo1, Y. Cho3, G. Han4, B. Jun5, D. Kim5, K. Kim6, J. Lee7, K. Lee1, S. Lee10, I. Moon8, S. Park5, J. Seo5, S. Yeo9, J. Choi11, Y. Choung12, J. Chung2 ..................................... 41 Title: Ear and Hearing Outcomes from an Ear Bus Program in Western Australia .............. 43 Author: H. L. COATES ............................................................................................................ 43 Title: The Molecular Microbiological profile of Otitis Media with effusion in Chinese Children….. .............................................................................................................................. 44 Authors: J. Xu1,2, D. Ren1,2, W. Dai1,2 ..................................................................................... 44 Title: Effectiveness of a Multifaceted Intervention to Educate General Practitioners about Pain Management in Children with Acute Otitis Media: a Cluster Randomized Controlled Trial…… .................................................................................................................................