ホームページではパンフレットに収載されていない化合物，試薬のスケールアップのご用命を受け付けております。 www.tokyokasei.co.jp/jutaku/synthesis Nucleosides, Nucleotides, Nucleic Acids and Related Reagents Genetic information is stored in DNA as combinatorial codes Nucleosides and Their Analogs held in nucleosides and nucleotides, in which form it is passed Nucleosides are glycosylamines made by attaching a from parents to their offspring. Analogs of nucleosides and nucleobase to a ribose or 2’-deoxyribose, which can be nucleotides are used clinically as medicinal agents such as phosphorylated producing nucleotides. Nucleoside analogs reverse transcriptase inhibitors. Therefore, the preparation and are an established class of clinically useful medicinal agents development of these species as effective, selective and possessing a wide range of antiviral and anticancer activities. nontoxic antiviral and antitumor agents has been the subject Consequently, extensive modifications have been made to of intense research.1) both the heterocyclic base and the sugar moiety. Some In addition to this, the development of Polymerase Chain representative examples of these are 9-[(2-hydroxyethoxy) Reaction (PCR) methodology has brought a dramatic change methyl]guanine (acyclovir) developed by Elion in 1977, which and rapid development in studies of DNA. At the current time shows antiviral activity; 3'-azido-3'-deoxythymidine (AZT) the draft version in decoding and mapping human genome discovered by Mitsuya et al. in 1985 and used for the treatment has been almost completed, and the functional analyses of of HIV infection; and cytosine β-D-arabinofuranoside genome and analyses of “Single Nucleotide Polymorphism” (cytarabine) approved by the FDA in 1969 and which has been (SNP) are being vigorously pursued. Discovery of the RNAi shown to display a range anticancer activities. In addition, process has facilitated the fast progression of studies of RNA. modified nucleosides such as 2’-deoxy-5-methylcytidine are At the same time, chemically synthesized oligoDNA and ubiquitous in living systems, and their functions have received oligoRNA have been studied as potential antisense DNAs, due attention from the scientific community.2) siRNAs and DNA aptamers, as oligonucleotide therapeutic Protected nucleosides, in which reactive amino and hydroxyl agents, primers for PCR method, and elements of DNA groups have been masked, e.g. N6-benzoyl-5'-O-(4,4'- computers. dimethoxytrityl)-2'-deoxyadenosine (Bz-DMT-dA), have been used for chemical synthesis of DNA and RNA. A0559 10mg A2033 100mg 1g Pyrimidine Nucleosides and Their Analogs Nucleosides 6-Azauridine [54-25-1] 5-Azacytidine [320-67-2] A2052 1g 5g A2073 5g 25g A2232 20mg 100mg A2356 1g 5g A2431 1g NH2 N N HO O N O 1-(3,5-Anhydro-2-deoxy- OH 2,2'-O-Anhydro- Azidothymidine β-D-threo-pentofuranosyl)- 5-Aza-2'-deoxycytidine 1-β-D-Arabinofuranosyl- 5-methyluridine [30516-87-1] thymine [7481-90-5] [2353-33-5] uracil [3083-77-0] [22423-26-3] A2528 50mg A2942 25mg 100mg B0666 100mg 1g B1575 1g 5g B3087 1g 5g O O C NH2 N HN HO N NH2 HO O N O O 4 OH OH OH N3 N -Benzoyl-5'-O- 2'-Azido-2'-deoxyuridine 5-Bromo-2'-deoxyuridine (4,4'-dimethoxytrityl)-2'- Acadesine [2627-69-2] [26929-65-7] 5-Bromouridine [957-75-5] [59-14-3] deoxycytidine [67219-55-0] 2 Please inquire for pricing and availability of listed products to our local sales representatives. Nucleosides, Nucleotides, Nucleic Acids and Related Reagents B3094 1g 5g B3102 100mg 1g B3404 100mg B3631 1g 5g C0522 1g 5g 25g N4-Benzoyl-3',5'-O-(1,1,3,3- N4-Benzoylcytidine N4-Benzoyl-2'-deoxycytidine tetraisopropyl-1,3-disiloxanediyl)- [13089-48-0] [4836-13-9] Brivudine [69304-47-8] cytidine [69304-43-4] Cytidine [65-46-3] C0525 100mg 1g C2035 1g 5g C2207 1g 5g C2208 5g 25g C2878 1g 5g O NH C O(CH2)4CH3 F N H3C O N O OH OH Cytidine Sulfate 2,2'-O-Cyclocytidine 2,2'-O-Cyclouridine [32747-18-5] Cytarabine [147-94-4] Hydrochloride [10212-25-6] [3736-77-4] Capecitabine [154361-50-9] D0048 5g 25g D0060 1g 5g 25g D2235 100mg 500mg 1g D3566 5g 25g D3579 1g 5g 2'-Deoxycytidine 2'-Deoxy-5-fluorouridine 5'-O-(4,4'-Dimethoxytrityl)- 5'-Deoxy-5-fluorouridine Hydrochloride [3992-42-5] 2'-Deoxyuridine [951-78-0] [50-91-9] thymidine [40615-39-2] [3094-09-5] D3580 1g 5g D3583 1g 5g D3610 100mg 500mg 5g D3614 1g D3615 1g 5g 2'-Deoxycytidine 2'-Deoxy-5-methylcytidine 2'-Deoxy-2'-fluorocytidine 2'-Deoxy-2'-fluorouridine Stavudine [3056-17-5] [951-77-9] [838-07-3] Hydrate [10212-20-1] [784-71-4] D3642 1g D4200 10mg D4220 50mg 200mg D4342 1g 5g D4823 200mg 1g O NH2 NH2 O I CH2OH F HN N N HN HO O N HO O N H3C O N HO O N F H3C O O O O OH OH OH OH OH F 2'-Deoxy-5-fluorocytidine 2'-Deoxy-5-(hydroxymethyl)- 5'-Deoxy-5-fluorocytidine (2'R)-2'-Deoxy-2'-fluoro-2'- [10356-76-0] Fialuridine [69123-98-4] cytidine [7226-77-9] [66335-38-4] methyluridine [863329-66-2] E1057 50mg 200mg E1093 50mg 200mg F0534 1g F0635 5g 25g F0636 1g 5g O NH2 C CH C CH HN N HO O N HO O N O O OH OH 5-Ethynyl-2'-deoxyuridine 5-Ethynyl-2'-deoxycytidine 5-Fluorocytidine [61135-33-9] [69075-47-4] [2341-22-2] Tegafur [17902-23-7] 5-Fluorouridine [316-46-1] G0367 100mg 1g I0258 1g 5g 25g I0882 1g L0217 100mg 1g M1405 1g 5g 25g NH2 I N HO O N O OH Gemcitabine Hydrochloride 5-Iodo-2'-deoxycytidine 5-Methyluridine [122111- 03-9] Idoxuridine [54-42-2] [611-53- 0] Lamivudine [134678-17-4] [1463-10-1] M1931 1g M2290 1g 5g M2317 200mg 1g M2399 50mg 250mg R0077 100mg 500mg O NH2 O C NH2 HN N N HO O N HO O N HO N OH O O O OH OCH3 OH OCH3 OH OH 5-Methylcytidine 2'-O-Methyluridine 2'-O-Methylcytidine [2140-61-6] [2140-76-3] [2140-72-9] Mizoribine [50924-49-7] Ribavirin [36791-04-5] Please inquire for pricing and availability of listed products to our local sales representatives. 3 Nucleosides, Nucleotides, Nucleic Acids and Related Reagents Nucleosides, Nucleotides, Nucleic Acids and Related Reagents T0233 1g 5g 25g T2511 100mg 1g T2549 5g 25g U0020 5g 25g Z0022 200mg 1g N HO O N O OH OH Trifluorothymidine 2',3',5'-Tri-O-acetyluridine Thymidine [50-89-5] [70-00-8] [4105-38-8] Uridine [58-96-8] Zebularine [3690-10-6] A0152 5g 25g 100g A1915 1g 5g 25g A2054 1g 5g A2135 5g 25g Purine Nucleosides 2-Amino-6-chloropurine 2-Aminoadenosine Adenosine [58-61-7] Acyclovir [59277-89-3] Riboside [2004-07-1] [2096-10-8] A2414 100mg 1g A2739 10mg 50mg B3093 1g 5g B3101 100mg 1g B3103 100mg 1g O N NH HO N N NH HO 2 O 6 . xH O OH 2 N -Benzoyl-5'-O- 9-β-D- N6-Benzoyl- (4,4'-dimethoxytrityl)- Adefovir Dipivoxil Arabinofuranosylguanine N6-Benzoyladenosine 2'-deoxyadenosine 2'-deoxyadenosine [142340-99-6] Hydrate [38819-10-2] Hydrate [4546-55-8] Hydrate [206752-42-3] [64325-78-6] B3460 100mg 1g B4001 200mg 1g B4002 1g 5g C2192 100mg 1g C2206 1g 5g O O N NH N NH HO Br N N NH2 HO Br N N NH2 O O . 6 xH2O N -Dibenzoyladenosine OH OH OH 2',3'-Dibenzoate 8-Bromo-2'-deoxyguanosine 8-Bromoguanosine 2-Chloroadenosine Hydrate 6-Chloropurine Riboside [58463-04-0] [13389-03-2] Hydrate [4016-63-1] [146-77-0] [5399-87-1] C2499 50mg C2500 20mg 100mg C2689 25mg C2815 25mg D0046 5g 25g NH2 NH2 NH2 N N N N N N HO N N Cl HO N N HO N N O O O . xH2O OH OH OH Cordycepin from Cordyceps 2'-Deoxyadenosine Cladribine [4291-63-8] Clofarabine [123318-82-1] militaris [73-03-0] Cordycepin Hydrate [73-03-0] Monohydrate [16373-93-6] D0052 1g 5g 25g D3065 100mg D3066 100mg 500mg D3584 1g 5g D4137 5g 2'-Deoxyguanosine Hydrate 2',3'-Dideoxyadenosine 2'-Deoxyadenosine [961-07-9] [4097-22-7] Didanosine [69655-05-6] 2'-Deoxyinosine [890-38-0] Anhydrous [958-09-8] D4228 25mg D4256 1g 5g D4292 100mg 1g E0899 50mg 200mg F0656 200mg 1g O NH2 O HN CH3 Cl N N N HN N N N . H2O O N N N N O HO N Cl H2N N N O OCH2CH3 O CH2CH2OCH2 P CH2 OCH2CH3 O P O O CH3 ONa OH OH O Diethyl [[2-(6-Amino-9H- HO CH2OH Dibutyryl cAMP Sodium purin-9-yl)ethoxy]methyl]- 5,6-Dichlorobenzimidazole Entecavir Monohydrate 2-Fluoroadenosine Salt [16980-89-5] phosphonate [116384-53-3] 1-β-D-Ribofuranoside [53-85-0] [209216-23-9] [146-78-1] F0842 500mg 5g G0171 5g 25g 100g G0315 5g 25g H1290 5g 25g H1291 1g 5g O NH2 N N HN N . xH2O N N O H2N N N H2N N N N N CH2O C CH3 CH OH CH CH CH 2 2 2 CH2OCH CH CH2O C CH3 CH2OH 3 O OH Ganciclovir Hydrate 9-(2-Hydroxyethyl)- (R)-9-(2-Hydroxypropyl)- Famciclovir [104227-87-4] Guanosine [118-00-3] [82410-32-0] adenine [707-99-3] adenine [14047-28-0] 4 Please inquire for pricing and availability of listed products to our local sales representatives. Nucleosides, Nucleotides, Nucleic Acids and Related Reagents Nucleosides, Nucleotides, Nucleic Acids and Related Reagents I0037 25g 500g I0697 1g 5g I0699 100mg 1g I0700 100mg 1g I0702 5g 25g N2-Isobutyryl-5'-O- (4,4'-dimethoxytrityl)-2'- N2-Isobutyrylguanosine N2-Isobutyryl-2'-deoxy- 2',3'-O-Isopropylidene- Inosine [58-63-9] deoxyguanosine [68892-41-1] Monohydrate [64350-24-9] guanosine [68892-42-2] adenosine [362-75-4] I0703 5g I0704 5g I0759 200mg 1g 5g M2291 1g M2318 200mg 1g NH2 O N N N NH HO N N HO N N NH2 O O .