US 2013 004O942A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2013/0040942 A1 COWen et al. (43) Pub. Date: Feb. 14, 2013 (54) SALTS OF POTASSIUM ATP CHANNEL Publication Classification OPENERS AND USES THEREOF (51) Int. Cl. (75) Inventors: Neil M. Cowen, San Diego, CA (US); A63/549 (2006.01) Iain Dukes. Durham, NC (US) A6IP5/00 (2006.01) A6IP3/08 (2006.01) (73) Assignee: Essentialis, Inc. A6IP3/06 (2006.01) (52) U.S. Cl. .................................. 514/223.5: 514/223.2 Appl. No.: 13/543,665 (21) (57) ABSTRACT (22) Filed: Jul. 6, 2012 Provided are immediate or prolonged administration of cer tain salts of K channel openers such as diazoxide to a Related U.S. Application Data Subject to achieve novel pharmacodynamic, pharmacoki netic, therapeutic, physiological, metabolic and composi (63) Continuation of application No. 12/166,251, filed on tional outcomes in the treatment of diseases or conditions Jul. 1, 2008, now abandoned. involving K channels. Also provided are pharmaceutical (60) Provisional application No. 60/947,628, filed on Jul. 2, formulations, methods of administration and dosing of the 2007, provisional application No. 60/949,207, filed on salts that achieve these outcomes and reduce the incidence of Jul. 11, 2007, provisional application No. 60/950,854, adverse effects in treated individuals. Further provided are filed on Jul. 19, 2007, provisional application No. method of co-administering the salts with other drugs to treat 60/986,251, filed on Nov. 7, 2007. diseases of humans and animals. Patent Application Publication Feb. 14, 2013 Sheet 1 of 51 US 2013/004O942 A1 a S. 8 a II Š 8 C 2 N1 ?h al W / s. / 8 c E C V C 9 g o s CN C CN CN S CN Patent Application Publication Feb. 14, 2013 Sheet 2 of 51 US 2013/004O942 A1 CN O) v. CN Y LO O). OO CO cy) V. co Lo o co co O O. O LO CO. N. N. OO CO. O. S. O. O. O. O. O. O. 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