Journal of Alzheimer’s Disease 24 (2011) 1–9 1 IOS Press Supplementary Data Genetic Association of Sequence Variants Near AGER/NOTCH4 and Dementia Anna M. Benneta, Chandra A. Reynoldsb, Ulrika K. Erikssona, Mun-Gwan Honga, Kaj Blennowc, Margaret Gatza,d, Andrey Alexeyenkoa, Nancy L. Pedersena,d and Jonathan A. Princea,∗ aDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden bDepartment of Psychology, University of California at Riverside, Riverside, CA, USA cInstitute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden dDepartment of Psychology, University of Southern California, Los Angeles, CA, USA Handling Associate Editor: Emilio Di Maria Accepted 13 December 2010 Supplementary Table 1 All tested markers in relation to dementia risk Marker Gene Chromsome Position P twins P cc (standard P all P all (ALR) P all (standard (xtlogit) logistic) (xtlogit) logistic) rs1800625 PBX2 6 32260420 7.03E-04 1.64E-02 1.36E-06 2.02E-06 5.39E-06 rs204995 PBX2 6 32262263 1.51E-03 2.41E-02 4.68E-06 9.11E-06 1.50E-05 rs10916683 PLA2G2A 1 20173131 4.65E-01 3.37E-03 6.61E-04 3.77E-03 4.06E-04 rs12218 SAA1 11 18247897 3.78E-01 8.38E-02 1.31E-03 1.41E-03 5.21E-04 rs204993 PBX2 6 32263559 3.95E-03 3.43E-01 1.47E-03 3.96E-03 3.87E-03 rs3796530 REST 4 57492010 8.57E-01 5.26E-01 3.01E-03 3.18E-03 2.93E-03 rs1800629 TNF 6 31651010 8.01E-03 3.77E-01 3.58E-03 6.47E-03 1.17E-02 rs361525 TNF 6 31651080 7.12E-01 1.08E-02 7.61E-03 1.06E-02 7.61E-03 rs1446963 APCS 1 157826155 1.20E-01 3.50E-02 1.36E-02 4.15E-02 8.66E-03 rs20417 PTGS2 1 184916944 7.62E-01 3.97E-02 2.15E-02 6.76E-02 2.03E-02 rs16874962 PLA2G7 6 46791436 7.72E-01 4.60E-02 2.64E-02 6.98E-02 3.25E-02 rs6687495 PTGS2 1 184928130 7.67E-01 5.83E-02 2.65E-02 7.23E-02 2.52E-02 rs11670727 NAPSA 19 55554580 8.79E-01 2.86E-02 2.77E-02 7.73E-02 4.01E-02 rs3093662 TNF 6 31652168 7.06E-01 2.20E-02 2.79E-02 5.48E-02 2.35E-02 rs2745559 PTGS2 1 184918625 2.73E-01 3.14E-01 2.97E-02 1.03E-01 1.44E-02 rs1035798 AGER 6 32259200 2.58E-01 6.43E-02 3.00E-02 6.86E-02 5.02E-02 rs11560324 SERPINE1 7 100571842 5.48E-01 5.52E-01 3.50E-02 3.80E-02 6.81E-02 rs2227667 SERPINE1 7 100561469 2.56E-01 2.89E-01 3.53E-02 8.65E-02 5.87E-02 rs2049045 BDNFOS 11 27650817 5.09E-01 2.96E-01 3.73E-02 1.66E-02 3.55E-02 rs6265 BDNFOS 11 27636492 4.16E-01 3.92E-01 4.25E-02 3.11E-02 4.16E-02 rs4638289 SAA1 11 18242350 3.58E-01 4.73E-02 4.70E-02 9.21E-02 3.87E-02 rs1546762 IL6 7 22724028 5.58E-01 4.65E-01 4.96E-02 5.70E-02 2.59E-02 ∗Correspondence to: Dr. Jonathan A. Prince, Department of Med- ical Epidemiology and Biostatistics, Karolinska Institutet, Nobels Väg 12A, 171 77 Stockholm, Sweden. Tel.: +46 (0)8 524 86008; Fax: +46 (0)8 31 49 75; E-mail: [email protected]. ISSN 1387-2877/11/$27.50 © 2011 – IOS Press and the authors. All rights reserved 2 A.M. Bennet et al. / NOTCH4 and Dementia Supplementary Table 1 (Continued) Marker Gene Chromsome Position P twins P cc (standard P all P all (ALR) P all (standard (xtlogit) logistic) (xtlogit) logistic) rs1993373 SAA1 11 18237211 4.49E-01 5.11E-02 5.66E-02 9.11E-02 4.83E-02 rs1417938 CRP 1 157950810 8.06E-01 2.75E-02 6.04E-02 8.16E-02 7.33E-02 rs1050955 SERPINE1 7 100569180 4.38E-01 3.16E-01 6.09E-02 1.28E-01 1.07E-01 rs13375942 PLA2G2A 1 20164965 7.67E-01 6.59E-02 6.11E-02 1.33E-01 4.73E-02 rs9806366 SELS 15 99620480 1.54E-01 5.56E-01 6.44E-02 1.78E-01 8.51E-02 rs11772356 SERPINE1 7 100546603 7.42E-01 1.90E-02 6.56E-02 1.50E-01 7.42E-02 rs3796529 REST 4 57492171 3.59E-01 2.63E-01 6.57E-02 7.22E-02 7.89E-02 rs1446965 APCS 1 157829390 4.52E-01 1.67E-01 6.96E-02 1.50E-01 9.29E-02 rs1955160 APCS 1 157819888 1.84E-01 1.00E-01 7.09E-02 1.77E-01 8.73E-02 rs1829575 SAA1 11 18244326 4.14E-01 5.37E-02 7.35E-02 9.31E-02 6.00E-02 rs2856437 PBX2 6 32265342 9.44E-01 2.49E-02 7.66E-02 1.88E-01 6.21E-02 rs915654 LTA 6 31646476 5.08E-01 1.15E-03 7.78E-02 1.98E-01 9.61E-02 rs2069861 IL6 7 22738179 5.84E-01 9.64E-01 7.96E-02 1.56E-02 5.87E-02 rs3132940 GPSM3 6 32269374 1.74E-02 7.17E-01 7.98E-02 4.90E-02 9.53E-02 rs10499563 IL6 7 22727013 5.83E-02 5.59E-02 8.10E-02 1.91E-01 8.00E-02 rs7940510 SAA4 11 18205727 8.13E-01 7.25E-02 8.25E-02 2.99E-01 3.05E-02 rs8023057 LOC390503 14 94167309 2.20E-02 2.87E-01 8.32E-02 2.24E-01 5.08E-02 rs2227631 SERPINE1 7 100556258 8.07E-01 8.94E-02 9.05E-02 2.26E-01 1.37E-01 rs3753868 APCS 1 157823893 5.55E-01 3.25E-01 9.16E-02 2.07E-01 6.36E-02 rs1800684 AGER 6 32259972 1.30E-02 9.27E-01 9.29E-02 1.19E-01 1.02E-01 rs11024578 SAA2 11 18220663 5.77E-01 1.12E-01 9.69E-02 2.67E-01 6.56E-02 rs11030104 BDNFOS 11 27641093 5.04E-01 3.51E-01 1.13E-01 6.02E-02 1.63E-01 rs11024600 SAA1 11 18252386 6.03E-01 8.37E-01 1.17E-01 3.62E-02 8.30E-02 rs1800947 CRP 1 157950062 7.31E-01 1.42E-01 1.17E-01 2.80E-01 7.85E-02 rs1800796 IL6 7 22732771 7.20E-01 5.28E-01 1.19E-01 3.29E-01 9.70E-02 rs4947324 NFKBIL1 6 31636109 5.38E-01 3.25E-02 1.20E-01 3.20E-01 8.11E-02 rs10811661 LOC729983 9 22124094 5.51E-01 4.96E-03 1.29E-01 3.48E-02 2.44E-01 rs12732308 PLA2G2A 1 20170906 6.33E-01 1.05E-01 1.29E-01 1.67E-01 1.15E-01 rs2383208 LOC729983 9 22122076 2.56E-01 3.90E-03 1.42E-01 3.01E-02 2.73E-01 rs7103411 BDNFOS 11 27656701 4.65E-01 5.75E-01 1.42E-01 1.72E-01 1.77E-01 rs1520887 SAA2 11 18221147 8.18E-01 2.07E-01 1.48E-01 4.65E-01 5.73E-02 rs2445176 SAA4 11 18213097 5.41E-01 3.20E-01 1.51E-01 2.32E-01 1.13E-01 rs7149828 LOC390503 14 94165374 1.04E-01 3.90E-01 1.53E-01 6.44E-02 9.95E-02 rs3753869 APCS 1 157823462 6.25E-01 4.80E-01 1.72E-01 4.18E-01 1.04E-01 rs1554606 IL6 7 22735232 5.30E-01 2.30E-01 1.75E-01 1.33E-01 1.07E-01 rs2350780 LOC730033 7 136243509 2.17E-01 8.72E-01 1.78E-01 3.83E-01 2.07E-01 rs1880241 IL6 7 22725994 7.92E-01 1.62E-01 1.85E-01 1.94E-01 2.00E-01 rs1051931 PLA2G7 6 46780902 1.38E-01 4.57E-01 1.88E-01 3.33E-01 2.28E-01 rs1474347 IL6 7 22734649 6.73E-01 3.71E-01 1.89E-01 2.25E-01 1.11E-01 rs9874 SELS 15 99628927 3.36E-01 5.59E-01 1.99E-01 4.15E-01 2.56E-01 rs11265260 CRP 1 157966663 1.03E-01 4.90E-01 2.01E-01 2.93E-01 2.11E-01 rs11687733 IL1A 2 113272259 6.60E-01 1.57E-02 2.02E-01 6.85E-02 2.76E-01 rs7242 SERPINE1 7 100568165 7.66E-01 9.14E-01 2.20E-01 3.27E-01 3.13E-01 rs689466 PTGS2 1 184917374 3.38E-02 4.84E-01 2.21E-01 2.22E-01 1.72E-01 rs3753867 APCS 1 157823993 4.91E-01 4.98E-01 2.21E-01 5.02E-01 1.58E-01 rs12663103 GPSM3 6 32269302 7.03E-01 1.26E-01 2.26E-01 4.09E-01 2.61E-01 rs9472830 PLA2G7 6 46797721 1.10E-01 9.90E-01 2.28E-01 1.92E-01 3.04E-01 rs955587 PLA2G2A 1 20175738 9.77E-02 3.28E-01 2.32E-01 2.46E-01 2.76E-01 rs17826482 SERPINA3 14 94154155 3.41E-01 9.55E-01 2.33E-01 4.73E-01 2.46E-01 rs2227692 SERPINE1 7 100565964 1.88E-01 3.67E-01 2.33E-01 4.77E-01 2.49E-01 rs1378650 CHRM2 7 136355691 4.32E-01 4.26E-02 2.33E-01 3.88E-01 2.02E-01 rs1520886 SAA2 11 18221314 5.30E-01 7.75E-01 2.33E-01 4.05E-02 4.54E-01 rs10911902 PTGS2 1 184898940 5.24E-01 3.28E-01 2.37E-01 3.30E-01 2.04E-01 rs2030324 BDNF 11 27683491 6.49E-01 4.29E-01 2.60E-01 4.85E-01 3.10E-01 rs11677 PLA2G2A 1 20174551 1.05E-01 3.64E-01 2.64E-01 2.44E-01 3.04E-01 rs2256974 LST1 6 31663371 3.99E-01 5.33E-04 2.68E-01 5.05E-01 3.13E-01 rs3134943 RNF5 6 32255739 2.64E-02 6.93E-01 2.70E-01 2.27E-01 3.22E-01 rs1955659 LOC390503 14 94165906 3.78E-01 4.96E-01 2.72E-01 3.79E-02 1.17E-01 rs2229094 LTA 6 31648535 1.40E-01 4.73E-02 2.85E-01 2.84E-01 2.23E-01 rs7530853 PLA2G2A 1 20188186 4.79E-01 9.03E-01 2.85E-01 2.38E-01 2.77E-01 A.M.