MARCH OF DIMES PRIZE IN DEVELOPMENTAL BIOLOGY RECIPIENT LIST 2015 Investigator, Howard Hughes Medical Institute Rudolf Jaenisch, MD Whitehead Institute for Biomedical Research, For pioneering work in human cytogenetics and the normal and and Professor of Biology abnormal function and behavior of the X and Y chromosomes. Massachusetts Institute of Technology, Cambridge, MA 2010 For devising innovative technologies that elucidated long-standing Shinya Yamanaka, MD, PhD * dilemmas in developmental biology, for recognizing the L.K. Whittier Foundation Investigator in Stem Cell Biology transformative significance on cellular function of epigenetic Gladstone Institute of Cardiovascular Disease programming, and for applying the power of induced pluripotent Professor, University of California, San Francisco stem cells to novel discoveries. Director, Center for iPS Cell Research and Application 2014 For research on how certain master genes and protein signals regulate Huda Y. Zoghbi, MD formation and growth of organs such as the brain and limbs during Professor, Departments of Pediatrics; Molecular and Human Genetics; embryonic and fetal development. Neurology; Neuroscience; Programs in Cell and Molecular Biology and Developmental Biology 2009 Baylor College of Medicine, Houston, TX Kevin P. Campbell, PhD Carver Chair, Department of Molecular Physiology & Biophysics For pioneering work evolving from discovery that mutations in the X- Director of the Wellstone Muscular Dystrophy Cooperative Research linked MECP2 cause Rett syndrome and for studies elucidating the Center maintenance role of this epigenetic regulator in different neurons. Professor of Neurology and Internal Medicine 2013 University of Iowa, Roy J. and Lucille A. Carver College of Medicine, Eric Olson, PhD Iowa City, Iowa Annie and Willie Nelson Professorship in Stem Cell Research & Louis M. Kunkel, PhD Pogue Distinguished Chair in Research on Cardiac Birth Defects Professor of Pediatrics and Genetics, Harvard Medical School Robert A. Welch Distinguished Chair in Science Chief of the Division of Genetics Department of Molecular Biology The Children’s Hospital, Boston, Massachusetts University of Texas Southwestern Medical Center, Dallas, Texas For their pioneering research that has led to major new insights into the genetic and molecular causes of muscular dystrophy. For discovering genes and regulatory pathways governing development and growth of the cardiovascular system, and 2008 establishing a framework for how they function. Clifford J. Tabin, PhD George Jacob and Jacqueline Hazel Leder Professor 2012 Chair, Department of Genetics Howard Green, MD Harvard Medical School, Boston, Massachusetts George Higginson Professor of Cell Biology & Philip A. Beachy, PhD Department of Cell Biology The Ernest and Amelia Gallo Professor Harvard Medical School, Boston, Massachusetts Institute for Stem Cell Biology and Regenerative Medicine & Elaine Fuchs, PhD Stanford University School of Medicine, Stanford, California Rebecca C. Lancefield Professor Investigator, Howard Hughes Medical Institute Laboratory of Mammalian Cell Biology & Development Distinguished Professor and Co-Chairman Rockefeller University, New York, New York Department of Human Genetics Investigator, Howard Hughes Medical Institute University of Utah School of Medicine, Salt Lake City Professor, Institute for Frontier Medical Sciences & Oliver Smithies, DPhil, FRS * Kyoto University, Japan Excellence Professor of Pathology and Laboratory Medicine University of North Carolina, Chapel Hill For discovering how to reprogram adult skin cells into pluripotent embryonic-like adults stem cells. For the development of gene targeting in mice as a means of determining how genes function. 2011 2007 Patricia Ann Jacobs, OBE, DSc, FRS Dame Anne McLaren, DBE, DPhil, FRS, FRCOG Co-Director of Research, Principal Research Associate Wessex Regional Genetics Laboratory Wellcome Trust/Cancer Research UK Gurdon Institute Salisbury, Wiltshire, England University of Cambridge, England Professor of Human Genetics, & Janet Rossant, PhD, FRS, FRS(C) Southampton University Medical School Chief of Research, The Hospital for Sick Children & David C. Page, MD University Professor, Departments of Medical Genetics & Director, Whitehead Institute Microbiology and Obstetrics & Gynecology Professor of Biology, University of Toronto, Canada Massachusetts Institute of Technology, Cambridge For their remarkable contributions to our understanding of the entire 2001 cycle of mammalian reproduction and development, using the mouse Corey S. Goodman, PhD as a model system. Evan Rauch Professor of Neuroscience Director, Wills Neuroscience Institute 2006 University of California, Berkeley Alexander Varshavsky, PhD & Thomas M. Jessell, PhD, FRS Howard and Gwen Laurie Smits Professor of Cell Biology Professor, Department of Biochemistry and Molecular Biophysics Division of Biology Columbia University, New York, New York California Institute of Technology, Pasadena For their extraordinary body of work that has helped revolutionize the For explaining how ubiquitin, a tiny protein found in all living things, molecular understanding of central nervous system development and plays a major role in our lives by helping to regulate many crucial function. processes in human cells. 2000 2005 H. Robert Horvitz, PhD * Mario Capecchi, PhD * Professor of Biology Boswell Professor of Neurosciences Emeritus Massachusetts Institute of Technology, Cambridge Division of Biology California Institute of Technology, Pasadena For pioneering work in revealing genetic control over the active & Sydney Brenner, DPhil, FRS * process of programmed cell death or apoptosis. Distinguished Professor The Salk Institute for Biological Studies, La Jolla, California 1999 Sir Richard L. Gardner, PhD, FRS For their tremendously influential bodies of work which have helped Henry Dale Research Professor of the Royal Society to revolutionize and open up productive new fields of study in Oxford University, England molecular biology and genetics. & Sir Martin J. Evans, PhD, DSc, FRS * Professor of Mammalian Genetics 2004 University of Cambridge, England Mary F. Lyon, PhD, FRS Former Head, Genetic Section, MRC Mammalian Genetics Unit For pioneering techniques to identify and grow the embryonic stem Medical Research Council cells of mice in vitro and to introduce specific mutations into these Harwell, United Kingdom cells. For discovery of the process of X-chromosome inactivation. 1998 Davor Solter, MD, PhD Director and Member, Max-Planck-Institute of Immunobiology 2003 Department of Developmental Biology, Freiburg, Germany, and Pierre Chambon, MD Adjunct Senior Staff Scientist Professor and Director The Jackson Laboratory, Bar Harbor, Maine Institute for Genetics and Cellular and Molecular Biology, INSERM, Strasbourg, France For pioneering the concept of gene imprinting. & Ronald M. Evans, PhD Professor, Gene Expression Laboratory 1997 The Salk Institute for Biological Studies, La Jolla, California Walter J. Gehring, PhD Professor of Developmental Biology and Genetics, Biozentrum For discovering nuclear hormone receptors and characterizing their University of Basel, Switzerland structure and function. & David S. Hogness, PhD Munzer Professor of Developmental Biology and Biochemistry 2002 Stanford University School of Medicine, Stanford, California Seymour Benzer, PhD Boswell Professor of Neurosciences Emeritus For discovery and analysis of homeobox genes. Division of Biology California Institute of Technology, Pasadena 1996 & Sydney Brenner, DPhil, FRS * Beatrice Mintz, PhD Distinguished Professor Senior Member, Institute for Cancer Research The Salk Institute for Biological Studies, La Jolla, California Fox Chase Cancer Center, Philadelphia, Pennsylvania & Ralph L. Brinster, VMD, PhD For their tremendously influential bodies of work which have helped Richard King Mellon Professor of Reproductive Physiology to revolutionize and open up productive new fields of study in University of Pennsylvania School of Veterinary Medicine, molecular biology and genetics. Philadelphia For development of the transgenic mouse. NOTE: * Indicates Nobel Prize recipient or co-recipient. .