Pre-meeting Symposia • Sunday, June 14 Scientific Sessions • Sunday, June 14 - Thursday, June 18 Jointly sponsored by: National Lipid Association, Giovanni Lorenzini Medical Science Foundation Hosting Organizations: Boston Atherosclerosis Society, Weill Cornell Medical College Supporting Organization: Council on Arteriosclerosis, Thrombosis, and Vascular Biology, AHA INTERNATIONAL ATHEROSCLEROSIS SOCIETY Future ISA Meeting ISA 2012 March 25–30, 2012 Sydney, Australia Meeting Office 15000 Commerce Parkway, Suite C Mount Laurel, NJ 08054 Telephone: 856-439-0500 Fax: 856-439-0525 Email: [email protected] Table of Contents Address from the Presidents ................................................................................ 3 International Advisory Board ................................................................................ 4 Program Committees ........................................................................................... 5 Corporate Supporters .......................................................................................... 6 General Information .............................................................................................. 8 Exhibits ............................................................................................................... 14 Exhibit Floor Plan ............................................................................................... 20 Meeting-At-A-Glance .................................................................................... Insert Scientific and Poster Sessions ........................................................................... 21 Category Index ................................................................................................. 184 Author Index ..................................................................................................... 186 Notes ................................................................................................................ 211 Convention Center Map ............................................................Inside Back Cover Address from the Presidents Dear Colleagues, It is our pleasure to welcome you to Boston, Massachusetts on June 14-18, 2009 for the XV INTERNATIONAL SYMPOSIUM ON ATHEROSCLEROSIS. This Symposium, held triennially under the auspices of the International Atherosclerosis Society, offers the world’s largest and most prestigious forum for the presentation of new research and clinical findings on Antonio M. Gotto, Jr. arterial disease. Co-President Atherosclerosis is the underlying cause of heart disease and stroke, which together account for more than half of all mortality and morbidity in developed societies. Advances in the detection, prevention, and treatment of cardiovascular disease continue to emerge as knowledge about the pathogenesis and biology of atherosclerosis increases. In recent years, ongoing awareness of the importance of lifestyle and drug therapies in cardiovascular risk reduction has been enhanced by Ernst J. Schaefer pharmacological innovations, the development of sophisticated imaging Co-President techniques, and the sequencing of the human genome. Treatment of coronary heart disease has shifted from a primary focus on LDL- C levels to the concept of global cardiometabolic risk, and there has been increased attention paid to the contributing role of other lipoprotein fractions including HDL and triglycerides and of inflammation in the development of atherosclerosis. Leading clinicians and scientific investigators from around the world have developed and will contribute to a cutting-edge program that aims to capture the scope and depth of the exciting field of atherosclerosis research and treatment. The Symposium will provide a comprehensive update on the challenges and questions currently shaping the field, as well as a clear picture of past and present advances and a look towards future, emerging strategies for the diagnosis, treatment, and prevention of atherosclerosis. We are delighted that you are joining us for what promises to be a stimulating professional and educational event, and we wish you a great stay in Boston. Antonio M. Gotto, Jr., MD, DPhil Ernst J. Schaefer, MD Co-President Co-President XV INTERNATIONAL SYMPOSIUM ON XV INTERNATIONAL SYMPOSIUM ON ATHEROSCLEROSIS ON ATHEROSCLEROSIS 3 International Advisory Board Chairman: Grundy S.M. (USA) Abdel-Aziz O. (Egypt) Fuster V. (USA) Notarbartolo A. (Italy) Assmann G. (Germany) Galli C. (Italy) O’Leary D.H. (USA) Aviram M. (Israel) Gensini G.F. (Italy) Olsson A.G. (Sweden) Avogaro A. (Italy) Ginsberg H.N. (USA) Ooi T.C. (Canada) Badimon L. (Spain) Goldberg A.C. (USA) Pagnan A. (Italy) Ballantyne C.M. (USA) Gotlieb A.I. (Canada) Paoletti R. (Italy) Barter P. (Australia) Greten H. (Germany) Patsch J. (Austria) Beisiegel U. (Germany) Gülec H.S. (Turkey) Pitt B. (USA) Bernini F. (Italy) Guyton J.R. (USA) Poledne R. (Czech Republic) Betteridge J. (UK) Hajjar D.P. (USA) Poli A. (Italy) Bonnet J. (France) Hamsten A. (Sweden) Rader D.J. (USA) Breslow J.L. (USA) Hancu N. (Romania) Reiner Z. (Croatia) Brewer H.B., Jr. (USA) Hanefeld M. (Germany) Rubba P. (Italy) Brites F. (Argentina) Hansson G.K. (Sweden) Rubinstein A. (Israel) Brown B.G. (USA) Hatton M.W.C. (Canada) Rye K.-A. (Australia) Calabresi L. (Italy) Havekes L.M. (The Netherlands) Sacks F.M. (USA) Calandra S. (Italy) Humphries S.E. (UK) Sadikot S.M. (India) Campbell G.R. (Australia) Juhan-Vague I. (France) Schaefer J. (Germany) Carmena R. (Spain) Kanjuh V. (Serbia and Schneider W.J. (Austria) Carrageta M. (Portugal) Montenegro) Scott J. (UK) Catapano A.L. (Italy) Kastelein J.J.P. (The Netherlands) Shepherd J. (UK) Ceska R. (Czech Republic) Katan M.B. (The Netherlands) Sniderman A. (Canada) Chait A. (USA) Kipshidze N.N. (Republic of Sposito A. (Brazil) Chandrakasan G. (India) Georgia) Staels B. (France) Channon K.M. (UK) Kisyanto Y. (Indonesia) Stalenhoef A.F. (The Netherlands) Chapman M.J. (France) Kita T. (Japan) Steiner G. (Canada) Chen J-W. (Taiwan, R.O.C.) Kolovou G. (Greece) Sullivan L.G. (Australia) Chen M-F. (Taiwan, R.O.C.) Kovanen P. (Finland) Szollar L.G. (Hungary) Corsini A. (Italy) Lauro D. (Italy) Tall A. (USA) Crea F. (Italy) Lauro R. (Italy) Taskinen M.-R. (Finland) Crepaldi G. (Italy) Leiter L.A. (Canada) Tikkanen M.J. (Finland) Cuevas A. (Chile) Leitersdorf E. (Israel) Tokgözoglu L. (Turkey) Curtiss L.K. (USA) Licata G. (Italy) Tremoli E. (Italy) Davignon J. (Canada) Mahley R.W. (USA) Tybjærg-Hansen A. (Denmark) De Backer G. (Belgium) Mancini M. (Italy) Uauy R. (UK) De Caterina R. (Italy) Manzato E. (Italy) Utermann G. (Austria) Després J.-P. (Canada) Marais D. (South Africa) Vainstein N. (Argentina) Ding P.Y.-A. (Taiwan, R.O.C.) Marchioli R. (Italy) Von Eckardstein A. (Switzerland) Djuric D.M. (Serbia and Marcovina S.M. (USA) Watts G. (Australia) Montenegro) Matsuzawa Y. (Japan) Wenger N.K. (USA) Drexler H. (Germany) McPherson R. (Canada) Xavier H. (Brazil) Durrington P.N. (UK) Mezzetti A. (Italy) Yamashita S. (Japan) Espiga De Macedo M. (Portugal) Mordasini R. (Switzerland) Yang Y. (China) Fellin R. (Italy) Moriguchi E. (Brazil) Ylä-Herttuala S. (Finland) Fernández-Britto J.E. (Cuba) Nabel E.G. (USA) Zambon A. (Italy) Ferrannini E. (Italy) Naruszewicz M. (Poland) Zhu J. (China) FitzGerald G.A. (USA) Nestel P.J. (Australia) Forte T. (USA) Newby A.C. (UK) Franceschini G. (Italy) Nissen S.E. (USA) Frikke-Schmidt R. (Denmark) Noseda G. (Switzerland) 4 Scientific Committees Congress Presidents International Atherosclerosis Antonio M. Gotto, Jr. (New York, NY, USA) Society (IAS) Ernst J. Schaefer (Boston, MA, USA) President: ISA 2009 Local Scientific Jean-Charles Fruchart (Loos, France) Program Committee Past President: Alan Daugherty (Lexington, KY, USA) Scott M. Grundy (Dallas, TX, USA) Michael A. Gimbrone, Jr. (Boston, MA, USA) Henry N. Ginsberg (New York, NY, USA) President Elect: Daniel Levy (Framingham, MA, USA) W. Virgil Brown (Atlanta, GA, USA) Peter Libby (Boston, MA, USA) Alice Lichtenstein (Boston, MA, USA) Secretary: Aldons J. Lusis (Los Angeles, CA, USA) Philip J. Barter (Sydney, Australia) Jose M. Ordovas (Boston, MA, USA) Paul M. Ridker (Boston, MA, USA) Treasurer: Vassillis I. Zannis (Boston, MA, USA) Sidney C. Smith, Jr. (Chapel Hill, NC, USA) ISA Program Committee Members at Large: Scott M. Grundy, Chair (Dallas, TX, USA) America: W. Virgil Brown (Atlanta, GA, USA) Ruth McPherson (Ottawa, ON, Canada) Jean-Charles Fruchart (Loos, France) Chris J. Packard (Glasgow, UK) Ada Cuevas (Santiago, Chile) Eder Quintao (São Paulo, Brazil) Pacific Rim: Jun-ren Zhu (Shangai, China) Shaukat M. Sadikot (Mumbai, India) Contact Information Europe: John J.P. Kastelein (Amsterdam, Scientific-Organizing Secretariats The Netherlands) Ann S. Jackson, MBA Richard Ceska (Prague, Czech Republic) Giovanni Lorenzini Medical Foundation 6535 Fannin, M.S. A-601 President XV ISA Congress: Houston, TX 77030 USA Ernst J. Schaefer (Boston, MA, USA) Phone: (+1) 713-797-0401 Regional Federation Chairs: Fax: (+1) 713-796-8853 Email: [email protected] Europe: S. Lale Tokgözoglu (Ankara, Turkey) Emanuela Folco, PhD America: Fondazione Giovanni Lorenzini Jean Davignon (Montreal, QC, Canada) Via A. Appiani 7 20121 Milan, Italy Asia: Phone: (+39) 02 29006267 Yuji Matsuzawa (Osaka, Japan) Fax: (+39) 02 29007018 Email: [email protected] Senior Advisers to the Board: Heiner Greten (Hamburg, Germany) Rodolfo Paoletti (Milan, Italy) Local Organizing Secretariat Antonio M. Gotto, Jr. (New York, NY, USA) Pam Ballinger, CMP Association Headquarters,