FRAUNHOFER INSTITUTE FOR CELL THERAPY AND IMMUNOLOGY IZI YEARS ANNUAL REPORT 2014 ANNIVERSARY ISSUE ANNUAL REPORT 2014 ANNIVERSARY ISSUE TABLE OF CONTENTS PREFACE ................................................................... .6 DEPARTMENT OF CELL-FREE BIOPRODUCTION ......86 Interview with the director Prof. Dr. Frank Emmrich ..............7 DEPARTMENT OF BIOANALYTICS AND 10 YEARS FRAUNHOFER IZI ..................................... 10 BIOSENSORS ........................................................... .92 Congratulatory messages for our anniversary .....................10 Milestones ........................................................................ .12 PRODUCTS AND SERVICES ......................................98 In public ............................................................................ .14 Business units ................................................................... .99 Conferences ..................................................................... .16 Products and services .......................................................100 The Fraunhofer IZI in the political sphere ............................18 Leipzig headquarters ........................................................107 Development .................................................................... .20 Bioanalytics and Bioprocessing Branch of Institute Spin-offs and company settlements ....................................22 in Potsdam-Golm .............................................................109 Department of Drug Design and Target Validation STRUCTURES AND FIGURES 2014 ............................ 24 in Halle (Saale) .................................................................110 Portrait of the institute .......................................................25 Extracorporeal Immunomodulation Project Group Organization ..................................................................... .26 in Rostock ........................................................................111 Key institute fi gures 2014 ................................................. .28 Quality management ...................................................... .112 DEPARTMENT OF CELL ENGINEERING .................... .30 SCIENCE LOCATION LEIPZIG ...................................114 Leipzig and the former trade fair grounds ....................... .115 DEPARTMENT OF IMMUNOLOGY .......................... .36 EVENTS ...................................................................118 DEPARTMENT OF CELL THERAPY ...........................48 The Fraunhofer IZI in public ..............................................119 Looking to 2015 ..............................................................123 DEPARTMENT OF DIAGNOSTICS .............................56 SCIENTIFIC PRESENCE .............................................124 DEPARTMENT OF DRUG DESIGN AND Conventions and conferences ......................................... .125 TARGET VALIDATION ............................................. .64 Research partners .......................................................... .126 Industry partners ..............................................................131 BIOANALYTICS AND BIOPROCESSING Advanced vocational training ...........................................133 BRANCH OF INSTITUTE .......................................... .70 Teaching activities ............................................................136 Evaluator activities .......................................................... .138 DEPARTMENT OF BIOSYSTEM Association memberships .................................................140 INTEGRATION AND AUTOMATION ........................ .74 Publications .................................................................... .142 Published abstracts of posters and papers ....................... .148 DEPARTMENT OF CELLULAR BIOTECHNOLOGY .... .80 Other publications .......................................................... .161 4 | Fraunhofer IZI Annual Report 2014 Book articles ....................................................................161 Graduation (class of 2014) ...............................................162 Prizes .............................................................................. .164 Patents ........................................................................... .165 FURTHERANCE .......................................................166 Sponsors and advisory board of the Fraunhofer IZI .......... .167 FRAUNHOFER-GESELLSCHAFT ...............................168 The Fraunhofer-Gesellschaft in profi le ............................. .169 Fraunhofer Group for Life Sciences.................................. .171 FRAUNHOFER IZI CONTACT INFORMATION ...........172 How to reach us ............................................................. .173 Contact .......................................................................... .174 Information service ......................................................... .175 Editorial notes ..................................................................176 Fraunhofer IZI Annual Report 2014 | 5 PREFACE ”My thank-you for these past ten years at the Fraunhofer IZI not only goes to all our patrons, but above all to our dedicated members of staff at the institute.” Prof. Dr. Frank Emmrich, Institute Director, founded the Fraunhofer IZI in 2005 6 | Fraunhofer IZI Annual Report 2014 INTERVIEW WITH THE DIRECTOR PROF. DR. FRANK EMMRICH Professor Emmrich, this report is surely one of great successes, would certainly not have been possible without signifi cance for you and the Fraunhofer IZI. In its 2015 our staff‘s commitment and excellent teamwork. On this year of publication, the institute is celebrating its tenth note, I would like to take this opportunity to say a huge anniversary, which is why we are also using the 2014 thank you to all those involved. annual report to look back over the past ten years. How have you, as initiator and founder of the institute, A further substantial boost was given to the constant perceived the developments of the past ten years and growth at the Leipzig site in July 2014 through the what moments have you found particularly moving? affi liation of an existing branch in Potsdam. How did In order to answer this question, we have to go back a little this come about and what consequences does this further than ten years. Setting up an institute without fi rst entail for the strategy adopted by the Fraunhofer IZI? having a respective research unit at the Fraunhofer- After having set up a site focused on drug discovery in Halle Gesellschaft was completely unheard of. However, 15 years an der Saale in 2013 with the support of the Land of Saxony- ago there was an infectious spirit of optimism around the Anhalt, we went on to acquire a division based at the science world in the fi eld of biotechnology, which led to politicians campus in Potsdam in 2014 which deals with the research prompting the rather technically oriented Fraunhofer- and development of biological processes and bioanalytical Gesellschaft to strengthen its expertise in this area. procedures. With the support of the Board, the Fraunhofer IZI has taken on the task of remedying the division‘s structural A few years before the institute was set up, a competition and economic problems over the next few years and thus took place where concepts were put forward; during combining the biomedical expertise from Leipzig with the this process, most members of the Fraunhofer supervisory knowledge of process engineering and device development bodies voted in favor of developing a focus on cell therapy offered in Potsdam-Golm. and immunology. This was a very courageous decision at the time as it could not yet be foreseen whether cells and tissues In the 2014 reporting year, the institute can also look would really gain relevance as a new form of therapy for back on many other events which have a direct large-scale clinical application and thus whether the fi eld infl uence on its future development. What were your would be embraced by industry. I am extremely happy to say personal highlights? that the prognoses I made at the very beginning have now Together with Leipzig University of Applied Sciences (HTWK), come to fruition. The institute‘s rapid growth to almost 500 we created the specialist group ”Image Analysis of Cell members of staff across four German and two international Function” around the middle of the year, which is headed up locations, not to mention the scientifi c and economic by Professor Ulf-Dietrich Braumann from the Faculty for Fraunhofer IZI Annual Report 2014 | 7 PREFACE Electrical Engineering. The group aims to be able to measure 2014 also brought with it intensive discussions and and display cellular functions as continuously as possible negotiations with our Canadian cooperation partners at the without impairing the respective object under cell-culture McMaster University in Hamilton, Ontario. McMaster conditions. University belongs to the three leading universities in Canada that focus on the fi eld of biotechnology. A jointly operated The ceremonial foundation of the group, which was project center for ”Bioengineering and Advanced witnessed by the Minister Presidents of Saxony-Anhalt and Manufacturing (BEAM)” aims to drive forward project work Saxony alongside the University Rectors of the Universities of with many biotechnology companies in Canada and the USA, Halle-Wittenberg and Leipzig and the President of the to the benefi t of both parties. Fraunhofer-Gesellschaft, also served to