TABLE OF CONTENTS Congress Information ISCBFM Welcome Letter .................................................. 2 Committees ...................................................................... 3 About ISCBFM ................................................................. 4 About Yokohama .............................................................. 5 Awards ............................................................................. 6 Information A to Z ............................................................. 8 Information for Chairs & Speakers ..................................12 Access and Floor Guide ..................................................16 Scientific Program ISCBFM Meetings ...........................................................19 Social Events ................................................................. 20 Official Brain & Brain PET 2019 Satellites ...................... 21 Program at a Glance ...................................................... 24 Thursday, July 4th .......................................................... 30 Friday, July 5th ............................................................... 36 Saturday, July 6th ........................................................... 48 Sunday, July 7th ............................................................. 62 Poster Session Friday, July 5th ............................................................... 77 Saturday, July 6th ..........................................................104 Sunday, July 7th ............................................................130 Sponsors and Exhibitors Exhibition Floor Guide ...................................................158 Acknowledgments .........................................................159 Person Index .....................................................................161 ISCBFM WELCOME LETTER On behalf of the President, Local Organizing Committee and Program Committee of the International Society for Cerebral Blood Flow and Metabolism (ISCBFM), we wish you a warm welcome to BRAIN ＆ BRAIN PET 2019, the 29th International Symposium on Cerebral Blood Flow, Metabolism and Function in conjunction with the 14th International Conference on Congress information Congress Quantification of Brain Function with PET to be held in Yokohama, Japan from July 4-7, 2019. Following the tradition of previous biannual meetings, BRAIN ＆ BRAIN PET 2019 will cover numerous aspects within the area of neuroscience research, particularly those related to brain function and metabolism, cerebral blood flow, the function of the neurovascular unit and the blood-brain barrier, brain imaging, brain repair, and cerebrovascular pathology. Our goal is to present the state-of-the art and novel discoveries of these fields in the conference. Yokohama, the second largest city in Japan, is located next to Tokyo along the coastline of the Pacific Ocean, and is the first harbor city introduced to the world as the entrance to Japan. Since the time its port was opened, Yokohama has been vigorously acquiring new cultures and information from countries all over the world, and deserves its title as the birthplace of Japan’s modern culture. Thanks to the myriad views of the port, a unique and fascinating townscape Scientific program has developed, which augments its various artistic and cultural attractions. Yokohama offers plenty of opportunities to experience Japanese culture including delicious and diverse dining experiences of the world heritage “Washoku,” traditional dietary culture of Japan. In addition, it has wonderful accessibility to various famous sightseeing spots such as Tokyo, Mt Fuji, the historic town of Kamakura and hot spring resort areas in Hakone. Yokohama will provide the delegates and their families with a wealth of opportunities for discoveries and adventure, at the conference and beyond. A stimulating program combined with a wonderful location, will hopefully make this conference an exciting event. We very much look forward to your participation in BRAIN ＆ BRAIN PET 2019 and to welcoming you to Yokohama. Poster sessions Poster Yours Sincerely, Eng H. Lo Hiroyuki Kinouchi Hidehiko Okazawa Martha O’Donnell Kazuto Masamoto ISCBFM President Local Chair Local Chair Scientific Program Scientific Program Committee Chair Committee Chair Sponsors and Exhibitors Sponsors 2 COMMITTEES Committees Scientific Program Committee President William A. Banks, United States Eng H. Lo, Ph.D. Gregory Bix, United States Professor, Nicolas Blondeau, France Neuroprotection Research Laboratory, Ronald Boellaard, the Netherlands information Congress Department of Neurology and Radiology, Jan Booij, the Netherlands Massachusetts General Hospital, Johannes Boltze, Germany Harvard Medical School, United States Britta Engelhardt, Switzerland Zsuzsanna Fabry, United States Local Organizing Committee Jessica A. Filosa, United States Local Chairs Fahmeed Hyder, United States Hiroyuki Kinouchi, M.D., Ph.D. (Past Program Committee Chair) Professor, Hiroyuki Kinouchi, Japan (Local Co-chair) Department of Neurosurgery, Peiying Li, China University of Yamanashi, Japan Eng H. Lo, United States (President, ISCBFM) Hidehiko Okazawa, Japan (Local Co-chair) Scientific program Hidehiko Okazawa, M.D., Ph.D. Pedro Rosa-Neto, Canada Professor, Zoltan Ungvari, United States Biomedical Imaging Research Center, Zena Vexler, United States University of Fukui, Japan Bruno Weber, Switzerland Scientific Program Committee Chairs ISCBFM Officers Martha O’Donnell, Ph.D. Eng H. Lo, United States (President) Professor, Peter Herscovitch, United States Department of Physiology and Membrane (Past President) Biology, Hiroyuki Kinouchi, Japan (President Elect) School of Medicine, Nicolas Blondeau, France (Secretary) College of Biological Science, UC Davis, Jaroslaw (Jack) Aronowski, United States sessions Poster United States (Treasurer) Jun Chen, United States (Editor) Kazuto Masamoto, Ph.D. Professor, Society Brain Science Inspired Life Support ISCBFM Administrative Office Research Center, International Society for Cerebral Blood The University of Electro-Communications, Flow and Metabolism (ISCBFM ) Japan 9650 Rockville Pike Bethesda, MD 20814, United States T: +1 301 6347001/F: +1 301 6347099 [email protected] 3 and Exhibitors Sponsors ABOUT ISCBFM The International Society of Cerebral Blood Flow and Metabolism (ISCBFM) is organized and operates exclusively to promote the advancement of education and research in the science of cerebral blood flow, cerebral metabolism and cerebral function throughout the world. Member interests range from the molecular and genomic mechanism of ischemia through clinical Congress information Congress investigations of cerebral blood flow and metabolism. The ISCBFM hosts biennial meetings in various locations throughout Asia, Europe and North America. The International Symposium on Cerebral Blood Flow, Metabolism and Function (BRAIN) and the International Conference on Quantification of Brain Function with PET (BRAIN PET) are held jointly and bring together a diverse group of investigators for the exchange of scientific information on regulation of cerebral blood flow and metabolism. The International Symposium of Cerebral Blood Flow and Metabolism was first held in 1964, with subsequent meetings held approximately every two years. It wasn’t until 1981, however, that the Society was formally established. At the time of the establishment of the Society, the Journal of Cerebral Blood Flow and Metabolism started publication and continues to be a Scientific program highly respected and cited monthly publication. It is relevant to neurologists, neurochemists, psychologists, pharmacologists, physiologists, biochemists, anesthesiologists, neuroradiolo- gists, neuropathologists, and neuroscientists. A flagship commitment of the ISCBFM is to support young and early career neuroscientists (Early Career Investigators-ECIs). At each BRAIN & BRAIN PET meeting, ISCBFM has consistently supported Student and Scholar ECIs and organized programs to enhance networking and mentorship. At the BRAIN & BRAIN PET 2019 meeting, ISCBFM awarded travel bursaries to 103 Student and Scholar ECIs from all corners of the globe. The Society is also sponsoring an Early Career Networking Social and will be rolling out a mentorship program. Poster sessions Poster Be sure to stop by the ISCBFM booth (#8) to learn more about the Society and the benefits of membership! Sponsors and Exhibitors Sponsors 4 ABOUT YOKOHAMA Yokohama, the second largest city in Japan, is located next to Tokyo along the coastline of the Pacific Ocean. The city has long prospered as an international port city trading with foreign countries that opened to the world in 1859, as it had favorable facilities to host ships from abroad. Since that time, Yokohama has been vigorously acquiring new cultures and informa- tion from other countries, and it developed a reputation as the source for new information from information Congress abroad that was disseminated around Japan, hence its nickname as the birthplace of Japan’s modern culture. 2019 will mark the 160th Anniversary of the opening of the port of Yokohama, and today the city, continues to boast an international population and cosmopolitan atmosphere. Along with Yokohama’s historical port, many other attractive, traditional sightseeing spots will welcome you. The largest Chinatown in Japan, the Yokohama Red Brick Warehouses and Yamashita Park are near the conference venue, PACIFICO Yokohama. Close by is the expan- sive Sankeien Garden