epilepsytoday Issue 143 September 2019 • £4.25 (free to members) Rescued by first-aid Discover how Jane’s friends and family made a difference when she needed first-aid Also in this issue • Professor Mark Richardson talks next-gen seizure detection devices • Case studies on finding work and employment • Latest research findings from the GGE conference epilepsy feature technologies have shown to have the Unlocking same performance in predicting seizures. That is why we are very motivated to promote the investigation of new the brain devices that are less invasive. Matt Ng speaks to Professor Mark Richardson, Long-term head of neuroscience at King’s College London. beneath-the-skin Mark discusses a new type of device that could EEG provides revolutionise seizure prediction a remarkable opportunity The technology to predict seizures in provided with real-time feedback about people with epilepsy is still in its infancy. their current level of seizure risk, using to record EEG Previous efforts have involved electrodes the device’s coloured lights. continuously placed invasively in direct contact with the brain. However, there is a new The study found the method was safe approach that could lead the way in and provided a reliable indication of Q: What new technology is effective seizure prediction for many. seizure risk for some of the people, so being developed to do this now? the concept was effective. However, the A: With the NeuroVista we looked at Q: What technology has been need for electrodes inside the skull was putting electrodes inside the skull. This used in the past to predict found too invasive and unfortunately, the solution involves placing electrodes seizures in an individual person? NeuroVista system is no longer available. outside the skull but underneath the A: The most important and convincing skin. It received CE-certification last study was carried out in Australia on Q: What are the benefits and spring, so has EU approval as a medical 15 people with epilepsy, using a system drawbacks of older technology? device. With this, we can record called NeuroVista. This system consisted A: The NeuroVista study obtained brainwaves 24/7 for weeks or even of electrodes placed directly on or in extremely high-quality data as it was months in a very unobtrusive way. the brain, connected to an electronic recorded directly from the brain. unit under the skin of the chest. This However, this also turned out to be This technology therefore has the unit communicated wirelessly with a the drawback, as the study was never potential to give us an accurate measure handheld device. Their brainwaves were continued due to how invasive the of the brain-state at any time over the then analysed, and the person was system was. Unfortunately, no other long-term. page2 September 2019 • epilepsy.org.uk/epilepsytoday epilepsy feature Q: In what way does it improve then the implant is no longer noticed. non-convulsive seizures. Many people on the older technology? The only thing patients should be aware with epilepsy have non-convulsive A: With the electrodes outside the skull, of is that if they need to have an MRI seizures. Also, seizure detection devices the implantation procedure is much less scan, the device needs to be removed. generally detect movement, muscle invasive and therefore carries a lower activity, heart rate and skin sweating – risk of infection and device-related Q: In what ways is it different which are indirect evidence of a seizure. complications. The location still provides to seizure detection devices good quality data, as the electrodes are that are being sold now? Only brainwave data is able to provide shielded from many sources of noise by A: Seizure detection devices sold today direct evidence of a seizure as well as the skin. are made for convulsive seizures and direct evidence of the current state of there is little evidence they work for the brain. Q: How does the new type of technology work? A: The implant consists of a 10cm wire The wireless device is with three electrodes to record the around the size of a £1 coin brainwaves, and a £1 coin-sized ceramic housing which contains the electronics. The wire and the housing are implanted under the skin with a brief local anaesthetic procedure. The device uses technology based on long-established inner ear implants used as a treatment for deafness. Therefore, after implantation under the skin it can be used for a very long period of time. There is no battery inside the housing – the device is powered using a well- known approach called induction. Inside the housing is a coil, and another coil is attached to the skin next to the housing with a medical-grade adhesive patch. These two coils lying close together allow the device to be powered wirelessly and allow brainwave data to be retrieved wirelessly from the device. The coil stuck to the skin is attached by a thin wire to a small box. This box is around the size of a credit card, which contains a battery and stores the brainwave data. The external coil and the box are attached by a thin cable which is the only visible part of the device. Q: Would it be difficult or painful to put in or impractical to have in for people? A: Studies from Denmark have shown that it is easy and safe to place underneath the skin. In 34 volunteers no device-related serious events were recorded. The procedure is carried out in 20-30 minutes under local anaesthesia. Some patients experience slight headaches for the first few days after surgery, but this tends to disappear and epilepsy.org.uk/epilepsytoday • September 2019 page3 epilepsy feature between sleep and seizures. Therefore it’s possible that understanding sleep quality might prove useful in empowering people with epilepsy and enabling them to have some control over their condition. Q: How can this technology currently improve on research? A: I see many areas where an objective count of seizures can help research. For example, in studies of new drug treatments for epilepsy, we rely on seizure diaries. However, we already know that seizure diaries can be unreliable. Then it gets difficult to be certain whether a new drug is effective or not. A second area of research might be in improving diagnosis for possible seizure events that happen rarely. In such a situation, it can sometimes be very difficult to reach a diagnosis. By recording beneath-the-skin EEG over a very long period of time, we might see the changes in brainwaves occurring during an event. Therefore, we could potentially make a definitive diagnosis more quickly. Q: What types of seizures term beneath-the-skin EEG provides a would it be able to detect? remarkable opportunity to record EEG A: Basically, any type of seizure that will continuously, and therefore have a fully Using very show brainwave changes on conventional objective and accurate record of seizures. long periods of EEG recordings would be detectable. However, there might be some types Q: What are the potential EEG recording of seizures where it is impractical to future benefits for people implant the electrodes over the area with this technology? will enable us where the seizure originates. Or the A: Our trial is part of the My Seizure to understand seizures might be masked by electrical Gauge initiative and funded by the Epilepsy noise from the muscles so you cannot Foundation of America. We’ll be looking at epilepsy much see the brainwaves clearly. the feasibility of using the EEG recordings to forecast seizures. If this is possible, it better Q: What are the potential could mean a huge improvement in quality benefits to people with epilepsy of life for some people. Another area of intense research of this new technology today? interest at the moment is understanding A: Today, the beneath-the-skin EEG- Many people with epilepsy describe the the patterns of seizure occurrence device is mainly made to accurately unpredictability of seizures as the most over time. It seems that in many people, measure the occurrence of seizures. stressful and disabling aspect of having seizures occur in complex cycles that Many people with epilepsy may not be epilepsy. Providing a warning signal would may be predictable. I believe that using able to report in their seizure diary all of tell a person with epilepsy when the risk very long periods of beneath-the- their seizures. They may not be aware of of having a seizure is high. Not only that, skin EEG recording will enable us to all of them or may forget seizures. but they would also know when there understand epilepsy much better than would be a low risk of seizure. People we do now. There’s also evidence that seizure diaries participating in the NeuroVista study are sometimes very inaccurate despite especially appreciated knowing when Q: What studies have been every effort to keep them up-to-date. they were at low risk. carried out already on this? How Which means it can be very difficult effective has it been shown to be? for a clinician treating someone with The beneath-the-skin EEG device is also A: Three studies have been carried out epilepsy to be certain whether changes able to pick up sleep patterns very well. so far; on healthy volunteers, people with in treatment have been effective. Long- We know there is a high correlation diabetes and people with temporal lobe page4 September 2019 • epilepsy.org.uk/epilepsytoday epilepsy feature epilepsy. What we’ve learned is that the skin EEG and wearable devices, while the seizures.
Details
-
File Typepdf
-
Upload Time-
-
Content LanguagesEnglish
-
Upload UserAnonymous/Not logged-in
-
File Pages6 Page
-
File Size-