Order: (888)-282-5810 (Phone) (818)-707-0392 (Fax) [email protected] Web: www.Abiocode.com DACH1 (C2) Antibody, Rabbit Polyclonal Cat#: R0756-3 Lot#: Refer to vial Quantity: 100 ul Application: WB Predicted M.W.: 78.5 kDa Uniprot ID: Q9UI36 Background: Dachshund homolog 1 (DACH1) is a transcription factor involved in regulation of organogenesis. It appears to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1- DACH1 complex. DACH1 may act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. It also inhibits TGF- beta signaling through interaction with SMAD4 and NCOR1 and binding to chromatin DNA via the DACHbox-N domain. Expression of DACH1 is lost in certain forms of metastatic cancer, and is correlated with poor prognosis. Other Names: Dachshund homolog 1, DACH Source and Purity: Rabbit polyclonal antibodies were produced by immunizing animals with a GST-fusion protein containing the C-terminal region of human DACH1. Antibodies were purified by affinity purification using immunogen. Storage Buffer and Condition: Supplied in 1 x PBS (pH 7.4), 100 ug/ml BSA, 40% Glycerol, 0.01% NaN3. Store at -20 °C. Stable for 6 months from date of receipt. Species Specificity: Human Tested Applications: WB: 1:500-1:1,000 (detect endogenous protein*) *: The apparent protein size on WB may be different from the calculated M.W. due to modifications. For research use only. Not for therapeutic or diagnostic purposes. Abiocode, Inc., 29397 Agoura Rd., Ste 106, Agoura Hills, CA 91301 Order: (888)-282-5810 (Phone) (818)-707-0392 (Fax) [email protected] Web: www.Abiocode.com Product Data: Fig 1. Western blot of total cell extracts from human MCF7, using Ab (R0756-3) at RT for 2 h. Last Update: 2/2012 For research use only. Not for therapeutic or diagnostic purposes. Abiocode, Inc., 29397 Agoura Rd., Ste 106, Agoura Hills, CA 91301.