Harshavardhan et. al. Int. J. Adv. Pharm. Biotech., 2016; 2(1): 1-9 doi.org/10.38111/ijapb.20160201001 International Journal of Advances in Pharmacy and Biotechnology Vol.2, Issue-1, 2016, 1-9 Research Article Open Access I J A P B HARSHODENT – “Innovative Herbal Tooth Paste” V. Vasu Naik, Harshavardhan Pathapati*, M. Sirisha Hindu College of Pharmacy, Guntur-522002, Andhra Pradesh, India. *Corresponding author e-mail: [email protected] Received: 05 April 2016 Revised: 26 April 2016 Accepted: 02 May 2016 ABSTRACT: Herbal products have a great eminence and elegance fortifying effect in our daily healthy life. Because of this enormous engage of herbal products in our daily life, the current trend espouse towards the herbal products. Tooth paste is one of the most widely used semi-solid dosage forms available in the paste (or) gel forms which have a great effect in maintaining the health of the teeth and aesthetic effect by ascertaining the abrasive action to the teeth. Because of that herbal tooth pastes have increased demand and awareness. The harsodent is free from artificial ingredients like parabens, SLS, saccharin, NaF (Fluoride source) and chlorine sources. In the present work Clove oil, Neem oil and Syzygium cumini (Neredu) powder are the active pharmaceutical ingredients (API) which helps in maintaining the activities of the herbal tooth paste. In the present investigation three formulations were prepared F1, F2, F3 by mixing the polymers like micro crystalline cellulose MCC, methyl cellulose MC and sodium carboxy methyl cellulose SCMC and the remaining ingredients constantly in every formulation. More over the formulated tooth paste is said to be available to the consumers in cheap and cost effective manner. Key words: Herbal tooth paste, Semi-solid dosage form, Toothache (Dentalgia), Abrasive action, Active pharmaceutical ingredients (API). INTRODUCTION: loose teeth, strengthening the gums and whitening of teeth as well as promote the History of tooth paste relief from toothache. More over the first In ancient days Indians, Egyptians and organic tooth paste was invented by a Romans are using the powdered ashes, egg dentist named as Dr. Washington Wentworth shells and myrrh to cleaning their teeth. In Sheffield somewhere around early 1850’s, ancient china and Greece peoples were used similarly the Colgate Company makes a claim the crushed oysters and crab shells along that consists of they are the first tooth paste with crushed bones and horns of various inventors in the world. animals in their tooth powders, on that Definition of tooth paste: occasion they achieve the good abrasive action with their formulated tooth powders. Tooth paste is a semi-solid dosage form In early 17th and 18th century peoples made available in the paste (or) gel forms which the tooth paste for their convenience to daily have a fortifying effect in the maintaining the use. Although the first tooth powder was health of the teeth and aesthetic effect by formulated by Chinese and Romans, mainly ascertaining the abrasive action to the teeth. in their formulation containing the charcoal And also it is used to achieve the suppressive (or) bark powder, ginseng, mint and salt are actions like toothache (Dentalgia), Halitosis the common ingredients. However they and Gingivitis (a gum disease) by eliminating believe that tooth pastes are useful to fix the www.ijapbjournal.com IJAPB 1 Harshavardhan et. al. Int. J. Adv. Pharm. Biotech., 2016; 2(1): 1-9 the dental plague and food particles from the More over most of the organic tooth teeth. pastes are engaged in strengthening the teeth and gums. The modern statement towards the tooth paste is majority of the cleaning action of the Disadvantages teeth was attained by the mechanical action of the toothbrush rather than the tooth paste. SLS present in organic tooth paste However in our daily routine activities we causes the drying out of tissues present cannot be separated from tooth brushing in mouth and ultimately SLS with a toothbrush and toothpaste. Tooth responsible for mouth cancer. If more brushing activities should be done 2-3 times a day mainly carried out after every meal. amount of organic tooth paste was swallowed, it causes the harmful effects Types of Tooth pastes exist in Market like gastric irritation purgative activity Tooth pastes are mainly categorized into two and in some cases it causes liver types. damage. Fluoride source present in the organic 1. Organic tooth pastes tooth paste may be responsible for 2. Herbal tooth pastes fluorosis and also over dose leads to Organic tooth pastes matting (a tooth disease), cancer, renal Organic tooth pastes are the oral hygienic (or) kidney failure and more. products consisting of mainly the organic Triclosan is an active ingredient in some ingredients which are intended for ensuring organic tooth pastes which consists of dental hygiene and removal of dental plaque. chlorine. The chlorine converted in to Applications chloroform by reacting with tap water, here chloroform is a probable The fluoride present in the organic carcinogenic agent. And also many tooth pastes help in the preventing of more studies state that bacteriae may cavities by means of remineralization develop the tolerance against Triclosan activity which means reformation of (Triclosan present in majority of enamel and bones so that helpful in the European tooth pastes). Halitosis treatment. Most of the organic tooth pastes having It facilitates the good oral hygienic the Diethylene glycol (DEG) used as a nature and fresh breath. polymer and moisturizing agent in the Organic tooth pastes having good germ formulation may cause the toxicity to killing activity because of this which it is the consumer. Because of this reason helpful in suppression of Dentalgia and Chinese officials recall the DEG Gingivitis. containing tooth pastes products in Calcium source present in the organic 2007. tooth paste gives marked good feel of Tooth pastes containing SLS may alter free from germs and elevates the mouth the taste perception by break down of freshening phenomenon. phospholipids that enable the Organic tooth paste posses stringent bitterness to the food materials by property due to glycerin and pH inhibiting the taste buds. All the organic tooth pastes in the market containing the artificial www.ijapbjournal.com IJAPB 2 Harshavardhan et. al. Int. J. Adv. Pharm. Biotech., 2016; 2(1): 1-9 sweetener sodium saccharin gets nut powder (kunkudukai), Stevia leaves converted into bitter taste upon powder, Sodium benzoate, Titanium di oxide, addition of excess amount of saccharin Oil of winter green and Purified water. source or prolong storage of tooth paste Tooth paste Ingredients list products. Apart from API tooth paste mainly consists of Herbal tooth paste the following agents. Herbal tooth pastes are the oral hygienic Abrasives: products maintaining the health of the teeth, containing mostly plant products (or) plant Abrasives are the specialized agents useful in derivatives meant for protecting the teeth removing food particles and waste materials and gums from the germs and useful in between the teeth thereby responsible for strengthening of the teeth without causing whitening of teeth. any sort of irritations and harmful effects to Examples: CaCO3, chalk, calcium phosphate, the teeth. Basically herbal tooth pastes are colloidal silica etc. very much safe in daily usage. Humectants: Applications Humectants are the agents which gives Herbal tooth pastes are non-toxic and mechanical strength and also wetting nature non-irritant in nature. to the tooth paste. These are also called as Herbal products ensure high degree of anti clustering agents and moisturizers purity and affectivity in daily use. Examples: Glycerin, PG, PEG, sorbitol, etc. Herbal tooth pastes resorts the perfect Polymers (or) binders: germ killing and dental analgesic These agents are intended for binding aspects properties. Because of this reason it is and show the consistency of the tooth paste. helpful in suppression of Dentalgia, Examples: PEG, PG, MCC, MC, SCMC, HPMC. Gingivitis and Halitosis. More over these herbal products are Surfactants: not responsible for any sort of Surfactants are the detergents responsible for dangerous consequences upon daily foaming character in tooth paste. These are usage. also called as foaming agents. Latest researches concluded that Herbal Example: SLS, soap nut powder, etc. tooth pastes are also used in the Preservatives: treatment of pimples. However most of the herbal tooth Mainly intended for preservation purpose pastes are free from SLS, parabens, and eventually these are anti microbial in fluoride (NaF) and chlorine (Triclosan) nature. sources. And also free from artificial Example: Methyl paraben, propyl paraben, sweetener sodium saccharin. sodium benzoate etc. MATERIALS AND METHODS Sweetener: Clove oil, Neem oil, Syzygium cumini (Neredu, Gives sweetness to the tooth paste and Jamun powder), Glycerin, Propylene glycol, enhances the customer willingness towards Calcium carbonate, Chalk, Micro crystalline the product. Cellulose, Methyl cellulose, Sodium CMC, Soap Example: Na-saccharin, stevia leaves etc. www.ijapbjournal.com IJAPB 3 Harshavardhan et. al. Int. J. Adv. Pharm. Biotech., 2016; 2(1): 1-9 Flavoring agents: and the polymer for 1 minute in a stainless steel bowl. Add solution S, mix for 2 min. These are responsible for flavoring aspects in Homogenize for 3 min. Transfer into the tooth paste and give freshness to the homogenizer at 20° C. Add the Sweeteners, costumer. the API and the flavor, mix for 1 min 30sec Example: Peppermint oil, wintergreen oil, under vacuum. Add the abrasives, mix for 3 fennel, eucalyptus oil etc. min under vacuum. Add the surfactant (or) METHODOLOGY detergent, mix for 1 min 30sec under vacuum. Methods for formulation of herbal tooth The total manufacturing time, and the time T paste necessary for the dispersion of the carbonates are measured for each paste In the formulation of herbal tooth pastes the prepared. following methods are Method: 3 (Optimized method) Method: 1 Mix binder (or) polymer, humectants and also Mix the humectants and polymer for 1 minute vehicle (in an amount of 5-40% by weight of in a motor and pestle.